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Biomedical subjects

A Ericson

Publications and source records attributed to A Ericson.

At least 91 records · Page 5Linked to original sources
PubMed1979

Impact of changing age and parity distributions of mothers on perinatal mortality in Sweden, 1953-1975.

A study was made on how the shift in the age and parity distribution of mothers affected the perinatal mortality in Sweden between 1953-55 and 1973-75. During these years the overall perinatal mortality rate fell from 29 to 13 per 1 000 births. The authors used the specific perinatal mortality rates by the mother's age and infant's birth order in 1973-75 to calculate what the overall perinatal mortality rate would have been with the age and parity distributions of mothers in 1953-55 and 1963-65. They conclude that only 1.4 of the 16 per 1 000 decline in perinatal mortality could be attributed to the shift in the mother's age and parity distribution.

Adult↗
PubMed1979

Perinatal mortality in Sweden. Analyses with international aspects.

The perinatal mortality in Sweden has been decreasing during the last four decades. From available vital statistics in 1976 Sweden's figures are the lowest internationally. The decline continues and in 1978 the figure was as low as 10.0 per thousand. The five-year period 1973--1977 has been specially analysed using medical birth records from all births. Data from an international perinatal study in 1973 coordinated by WHO have been treated in the same way. With birth weight (BW) specific mortality rates in groups of 250 g it is shown that late fetal deaths (LFD) are related to BW only for high BW and that early neonatal deaths (END) are inversly related to BW. There is no sex difference in LFD but a marked male dominance in END, with one third higher rate for the boys. BW specific mortality rates in BW groups of 250 g, separated in LFD and END can be used as a tool for evaluating the quality of perinatal care. The influence oof factors related to patterns and standards of living is emphasized. It is suggested that perinatal mortality should be given in its two components separately late fetal death rates (LFD) and early neonatal death rates (END).

Birth Weight↗
PubMed1979

Analysis of perinatal mortality rate in the Stockholm area.

During the period 1973--1976, a significant decrease in perinatal mortality from 14.2 to 10.4/10 newborns occurred in Sweden. In the Stockholm area, the mean perinatal mortality during the same period varied significantly between the different maternity hospitals, even when pre-term and high risk pregnancies were excluded from the comparison. The majority of hospitals with fewer deliveries and without pediatric wards had a perinatal mortality above the mean. Some explanations of these differences were also looked for in differences between the total population of the referral area of each maternity hospital. In the referral areas of the hospitals with a perinatal mortality above the mean, there were higher percentages of low-income households and over-crowded dwellings and fewer professional people than in the other area. The results suggest a need for analysis of individually-based data to find etiological factors which account for differences in perinatal mortality.

Adolescent↗
PubMed1979

Perinatal mortality among children of immigrant mothers in Sweden.

The perinatal mortality among the infants of foreign and Swedish mothers was studied with the help of the data submitted to the medical birth register in 1973--1976. Unexpectedly, the perinatal mortality was slightly lower among the infants of the immigrant mothers. This difference could not be explained by differences in the distribution by age or parity of the mothers or by the length of gestation of the infants. A conceivable explanation is that the foreign mothers constituted a favorably selected group.

Adolescent↗
PubMed1979

Delivery outcome in women employed in medical occupations in Sweden.

A study was made of the delivery outcome in women working in medical occupations in Sweden. One cohort of approximately 1500 women who worked in 31 hospitals for chronic diseases during the period 1965-1975 and who gave birth during those years was studied. Also all women working in medical occupations and delivered during the years 1973-1975 were investigated by matching existing data registers. It was found that caesarian sections and vacuum extractions were used more frequently than expected. A significantly increased perinatal death rate was noted in 1973, but could not be related to any specific occupational exposure known to represent an increased risk. No general increase in malformation rate was seen, but a local cluster, occuring at certain hospitals in the Gothenburg area in 1973-1974 was identified. No support was obtained for the hypothesis that the use of soap containing hexachlorophene is associated with an increased risk of perinatal death or malformation.

Abnormalities, Drug-Induced↗
PubMed1977

Surveillance of malformations at birth: a comparison of two record systems run in parallel.

The efficiency of two national record systems for malformation monitoring has been compared. During 1973 and 1974, two such registers were run in parallel in Sweden. One is based on specific report cards which are sent in when a malformed infant is born, the other is a computerised analysis of routine birth record diagnoses. Both systems lose a similar, and significant, proportion of malformed infants. The quality of diagnosis is lower in the system of routine birth records than in the system based on specific notifications--especially in infants with multiple malformations or with reduction malformations of the limbs. The specific report system is the only one suitable for monitoring of malformations; it is also somewhat quicker than the other system.

Abnormalities, Multiple↗
PubMed1977

Adenine metabolism in man. 1. After intravenous and peroral administration.

The basal plasma concentration of adenine and its renal excretion was studied in two men. For its analysis partly new chromatographic techniques were developed. The plasma concentration varied around 70 nmol/l; the renal excretion rate was, as reported earlier by other investigators, around 10 nmol/min. Loadings, intravenously during about 3 h and orally, both with about 30 nmol adenine per kg body mass revealed that most of the adenine was metabolized to nucleotide form. In the experiments with intravenous administration of adenine only about 2% of the given dose appeared in the urine as adenine and somewhat less as the easily precipitable metabolite 2,8-dihydroxyadenine. In the peroral loads, with higher plasma adenine concentrations, the ratios of the renally excreted two compounds were one to a few per cent higher.

Adenine↗
PubMedDate not supplied

Nonsteroidal anti-inflammatory drugs in early pregnancy.

A study was performed of congenital malformations in infants whose mothers used nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy. Data were obtained from an ongoing prospective recording of drug use during the first trimester. During the period July 1, 1995 through December 31, 1998, 2557 infants were born to women who reported the use of NSAIDs in early pregnancy. The OR (after consideration of maternal age, parity, and smoking habits) for any congenital malformation was 1.04 (95%CI 0.84-1.29), but the OR for cardiac defects reported to the Medical Birth Registry was 1.86 (1.32-2.62) based on 36 instances, and for orofacial clefts 2.61 (1.01-6.78) based on only six instances. By using other information sources, another four infants with cardiac defects were identified. There was no drug specificity for cardiac defects but among six mothers of infants with orofacial clefts, five had used naproxen.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Purine metabolism of erythrocytes preserved in adenine, adenine-inosine, and adenine-guanosine supplemented media.

Four different media for erythrocyte preservation have been compared by studying 16 variables mainly describing the purine metabolism and glycolysis of the erythrocyte. The concentrations of the additives in the erythrocyte suspensions were as follows: adenine, 0.25 mmol/l; adenine, 0.75 mmol/l; adenine, 0.25 and inosine, 0.50 mmol/l; and adenine, 0.25 and guanosine, 0.50 mmol/l. Evaluated from the concentrations of glycerate 2,3-bisphosphate and purine nucleoside triphosphates, the medium with adenine-guanosine was superior to the others. In this medium with adenine-guanosine was superior to the others. In this medium the guanosine was rapidly split to guanine, which was slowly used for nucleotide synthesis or deaminated to xanthine. Differences between ATP and GTP in their reactivity with the two enzymes phosphofructose kinase seems to explain the beneficial effect of guanosine on preservation of erythrocytes.

Adenine↗
PubMedDate not supplied

Delivery outcome of women working in laboratories during pregnancy.

By record-linkage of the 1975 Swedish census and the Medical Birth Register of infants born in 1976, 1,161 infants were identified who were born to women coded as laboratory workers in the census. These infants were compared to all 98,354 infants born in Sweden in 1976. There was a higher than expected number of infants who died neonatally and/or had congenital malformations. Twenty-six singleton infants who either died or had serious malformations were selected for further study. To each of the cases, 2 controls were selected among the 1,161 infants. A questionnaire was sent to the 26 cases and 50 controls (2 cases had only 1 control each) asking about work during pregnancy. No specific type of laboratory work was found to be more common among the cases than controls.

Abnormalities, Drug-Induced↗