PubMed Health⌕ Search

Biomedical subjects

A Eroğlu

Publications and source records attributed to A Eroğlu.

12 recordsLinked to original sources
PubMed1999

Influence of perioperative whole blood transfusions on lymphocyte subpopulations in patients with stage II breast cancer.

Preliminary reports have suggested an adverse relationship between blood transfusion and survival after surgery in patients with solid tumour. One might postulate that from these studies, perioperative blood transfusions alter host immune defences. We therefore examined the influence of homologous whole blood transfusion on circulating lymphocyte subpopulations in transfused patients compared with non-transfused patients. Fifty-one women with Stage II breast cancer who underwent surgical procedures were studied. Patients were classified into two groups on the basis of whether or not they had received blood transfusion. The lymphocyte subpopulations were analyzed by flow cytometry before cancer surgery and three weeks after the operation. CD3+, CD4+, CD8+, and CD20+ cells as the lymphocyte subsets were quantitated using appropriate monoclonal antibodies. No significant differences between pre- and postoperative lymphocyte subset levels were seen in non-transfused patients. However, there was a statistically significant increase in the CD8+ cell count; decreasing CD4+ cell count and decreased CD3+ cells levels were observed in the transfused group (P < 0.05). Although these early results of the study suggest that the blood transfusions could be associated with alterations in lymphocyte populations, additional studies are needed to elucidate the possible mechanism of the transfusion-induced immunological modulations.

Blood Transfusion↗
PubMed1999

Primary hydatid cyst of the neck.

Hydatid cysts in the cervicofacial region are rare. We present an unusual case of a hydatid cyst found in the nape of a 66-year-old Turkish woman. There was no pulmonary or hepatic involvement. Excision of the cystic mass as definitive therapy was performed. The location of the lesion, diagnostic tests available and therapeutic approach are discussed and the literature reviewed.

Aged↗
PubMed1999

Serum concentrations of vascular endothelial growth factor and nitrite as an estimate of in vivo nitric oxide in patients with gastric cancer.

The importance of tumour angiogenesis in the process of tumour growth and progression in solid tumours has been widely accepted. Among many angiogenic factors, vascular endothelial growth factor (VEGF) has been shown to play a major role in the development and dissemination of the malignant tumours. Nitric oxide (NO) production was also observed in solid tumour tissues. NO has been reported to play an important role for the mitogenic effect of VEGF in the angiogenic process. However, little is known about the correlation between VEGF and NO in circulating levels. Therefore, we investigated serum VEGF and NO concentrations in human gastric cancers as well as healthy individuals, and examined the influence of tumour stage on circulating level of VEGF. The study consisted of 11 healthy individuals and 37 patients with primary gastric cancer who did not receive any prior therapy. Patients were categorized into four groups according to TNM classification. The level of VEGF165 in preoperative sera of gastric cancer patients and healthy donors was assayed using the quantitative sandwich enzyme immunoassay technique. NO concentration was estimated indirectly from serum nitrite. The ANOVA test showed a significant difference in serum VEGF165 concentrations between tumour stages (P < 0.001). A striking relationship was found between serum NO levels and tumour stage (P < 0.001). A significant difference was also seen between healthy individuals and patients with stage 1 disease. The present study suggested that large tumour burden was associated with significantly increased levels of VEGF165 and NO.

Adult↗
PubMed1999

Isolated chylothorax after penetrating trauma.

A case is presented with a left traumatic chylothorax, secondary to penetrating thoracic trauma, treated by conservative therapy. With this clinical report and the review of the literature, it is concluded that conservative management should be initially performed as alternative to surgical approach.

Bicycling↗
PubMed1998

Total thyroidectomy for differentiated thyroid carcinoma: primary and secondary operations.

AIMS: There is considerable controversy concerning the most appropriate surgical treatment of patients with differentiated thyroid carcinoma (DTC). Although some authors have advocated subtotal thyroidectomy because of the decreased surgical morbidity and the lack of improved survival with a more extensive procedure, total thyroidectomy has been defended by others as a treatment of choice with lower morbidity. METHODS: We reviewed 106 consecutive patients who had been treated with total thyroidectomy for DTC to determine the complication rate. Forty-seven patients had primary operations and 59 had reoperations with completion of total thyroidectomy. RESULTS: Residual tumour in the remnant thyroid tissue was found in 53.8% of patients who underwent prophylactic completion thyroidectomy. Permanent hypoparathyroidism was present in one (0.9%) patient and accidental transient unilateral recurrent laryngeal nerve injury occurred in 2.8% of the entire series. No patient had permanent bilateral recurrent nerve palsy. Furthermore, the risk of complication was not significantly different when comparing primary total thyroidectomy or completion surgery. CONCLUSIONS: We recommend total thyroidectomy as a safe treatment for DTC with a low rate of morbidity.

Adenocarcinoma, Follicular↗
PubMed1997

Risk factors for locoregional recurrence of scar carcinoma.

BACKGROUND: Squamous cell carcinoma (SCC) arising from scar tissue is rare and has a higher rate of recurrence than SCC arising in sunlight-damaged skin. The risk factors related to locoregional recurrence in scar carcinoma were analysed retrospectively. METHODS: Ninety-one patients with SCC arising from scar tissue treated from January 1980 to January 1992 were studied. The following factors were evaluated using univariate and multivariate methods for locoregional recurrence: patient age, sex, tumour size, anatomical location, histological differentiation, cause of scar and regional lymph node dissection. RESULTS: With a median follow-up of 30 months locoregional recurrence developed in 27 patients. The median interval to recurrence was 15 months. Sex (P = 0.0278), tumour size (P = 0.0491), and tumour grade (P = 0.0019) were found to be associated with recurrent disease by univariate analysis, but on multivariate analysis only sex and tumour grade were risk factors for recurrence. CONCLUSION: Careful follow-up after treatment is recommended especially for female patients and those with high-grade tumours.

Adolescent↗
PubMed1996

Risk factors related to locoregional recurrence in squamous cell carcinoma of the skin.

A retrospective analysis was performed to identify the risk factors associated with development of locoregional recurrent disease in patients with primary squamous cell carcinoma of the skin. Step-wise logistic regression analysis was used in this study, which consisted of 1,039 patients treated from January 1980 to December 1989 at Ankara Oncology Hospital. Locoregional recurrence occurred in 187 (18%) of these patients within a mean disease-free period of 15 months. Age, sex, anatomical location, size of lesion, lymph node, status at diagnosis, stage according to TNM classification, histopathologic grade, previous therapy, treatment modality, lesions arising from scar tissue (scar carcinoma), regional lymph node dissection, concomitant premalignant tumor of the skin, development secondary nonmelanotic skin carcinoma, and second malignancy were used as variables that could be correlated with locoregional recurrent disease. No correlation was found between development of recurrence and previous therapy, second nonmelanoma skin cancer, second malignancy, premalignant skin tumor, sex, or regional lymph node dissection. Although univariate analysis demonstrated that location, tumor size, patient's age, lymph node status, stage, histopathologic grade, scar carcinoma, and treatment modality were associated with an increased risk of locoregional recurrence, it was found that stage of the disease (P < 0.001), treatment modality (P < 0.01), tumor arising from scar tissue (P < 0.01), and histopathologic grade (P < 0.05) were statistically significant as risk factors of recurrence when a multivariate analysis was applied.

Adolescent↗
PubMed1995

Completion thyroidectomy for differentiated thyroid carcinoma.

Completion thyroidectomy is defined as the surgical removal of the remnant thyroid tissue following procedures less than total or near-total thyroidectomy. The extent of surgical management for differentiated thyroid carcinoma (DTC) is controversial. Although some authors advocate subtotal thyroidectomy with lower complication rates, total or near-total thyroidectomy and completion thyroidectomy have been defended by others because of the improved survival and lower morbidity that is comparable with subtotal thyroidectomy. In this study, the incidence of residual tumor and surgical complication rates in patients who underwent completion thyroidectomy were investigated. The medical records of 165 patients undergoing completion thyroidectomy for DTC were reviewed. Seventy-seven (46.6%) of these patients were found to have residual tumor in the remaining thyroid tissue. Anaplastic transformation developed in two of these patients. Permanent bilateral recurrent laryngeal nerve palsy occurred in three patients, and permanent hypoparathyroidism was seen in one patient. We recommend completion thyroidectomy as an efficient and safe method of surgical treatment with a low complication rate for DTC.

Adolescent↗
PubMed1992

The frequency of pseudoexfoliation syndrome in the eastern Mediterranean area of Turkey.

In this study we evaluated the frequency of pseudoexfoliation syndrome, the percentages of glaucoma and senile cataract in patients with and without pseudoexfoliation syndrome, and the percentages of pseudoexfoliation syndrome in patients with glaucoma and senile cataract in the Eastern Mediterranean area of Turkey. We examined 1356 persons over 40 years of age. Frequency of pseudoexfoliation syndrome in the greater than or equal to 50 years old age band was 7.2%, and there was a statistically significant difference between the sexes. Over 60 years of age, the frequency of pseudoexfoliation syndrome was 11.2%, the percentage of glaucoma in patients with pseudoexfoliation syndrome was 34.3%, the percentage of pseudoexfoliation syndrome in patients with glaucoma was 46.9%, the percentage of cataract in persons with pseudoexfoliation syndrome was 88.1%, and the percentage of pseudoexfoliation syndrome in persons with cataract was 17.7%. The differences between the percentage of glaucoma and cataract in patients with and without pseudoexfoliation syndrome, were both statistically significant (p less than 0.001).

Adult↗
PubMedDate not supplied

Metastatic carcinoma of the gallbladder due to renal cell carcinoma in the ectopic kidney.

We report a rare case of secondary involvement of the gallbladder by metastatic renal cell carcinoma originating from ectopic kidney. The first diagnosis of the patient is a gallbladder carcinoma due to a polypoid mass within the gallbladder. The preoperative examinations revealed that there was also a synchronous renal cell carcinoma. The histopathologic examination of the polypoid mass and kidney after operation revealed the resected polypoid mass to be metastasis of renal cell carcinoma.

Carcinoma, Renal Cell↗
PubMedDate not supplied

Ocular involvement in childhood leukemias.

Ocular involvement was detected in 36 of 84 children suffering from acute leukemia. The major manifestation of leukemic ophthalmology was retinal hemorrhage. Neither platelet counts nor hematocrit values correlated with the occurrence of hemorrhages. As the eye is a pharmacologic sanctuary, it is emphasized that full ophthalmologic evaluation of leukemic patients is a critical part of their follow-up and will guide the choice of therapeutic regimen.

Adolescent↗