Prevalence of hepatitis C virus antibody in patients with systemic lupus erythematosus.
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Adolescent↗
Biomedical subjects
A Ersoy
Publications and source records attributed to A Ersoy.
Inhibition by nicotine of the vasodilator effect of bradykinin: evidence for a prostacyclin-dependent mechanism.
In urethane-anesthetized rabbits, bradykinin caused a dose-dependent hypotension. This hypotensive response was not altered in magnitude but was inhibited in duration after pretreatment with nicotine. Nicotine failed to inhibit the hypotensive effect of eledoisine, prostacyclin, isoprenaline and papaverine. Aspirin pretreatment, however, caused a marked inhibition in both magnitude and duration of the hypotensive effect of bradykinin without altering that of eledoisine, isoprenaline, papaverine and prostacyclin. Bradykinin also produced a concentration-dependent fall in perfusion pressure of the isolated perfused guinea-pig heart. Addition of nicotine to the perfusion medium caused a significant inhibition in both magnitude and duration of the vasodilator response to bradykinin. Nicotine did not alter the vasodilation induced by prostacyclin. Nicotine also failed to abolish the vasodilator effects of isoprenaline, histamine, papaverine and eledoisine in the coronary circulation. Other antagonists such as atropine, propranolol, cimetidine did not alter the vasodilator effect of bradykinin. These results were taken as the evidence indicating that the vasodilator action of bradykinin is mediated through the release of prostaglandins; the peptide selectivity increases the release of prostacyclin and this prostacyclin contributes to the bradykinin-induced vasodilation in guinea-pig coronary vessels.
Animals↗
Efficacy of sildenafil in male dialysis patients with erectile dysfunction unresponsive to erythropoietin and/or testosterone treatments.
The aim of this study was to evaluate the effects of recombinant human erythropoietin (Epo), testosterone (T) or a combination of them in the treatment of erectile dysfunction (ED) in hemodialysis patients, as well as the efficacy of sildenafil in patients unresponsive to combination treatment. A total of 23 patients with ED were divided into two groups. The international index of erectile function (IIEF) was used to evaluate ED and treatment response. Patients received Epo or T treatments for 12 weeks. Later on both groups received combination treatment for another 12 weeks. Although IIEF scores increased significantly in both groups after the combination treatment, the score changes were similar. After combination treatment, 16 patients still having IIEF score <26 were given sildenafil treatment in combination with Epo while T was discontinued. Although the IIEF scores increased significantly in all patients (17.4%), only eight of them attained an IIEF score of > or =26. The baseline IIEF scores of the patients with satisfactory response to the sildenafil treatment were higher than those with unsatisfactory response. The patients with a score of > or =22 responded better to the treatment. Although Epo and/or T therapies could partially improve ED in male dialysis patients besides correcting renal anemia and hypogonadism, sildenafil treatment could improve ED in unresponsive patients. Especially, those with higher baseline IIEF scores benefited more.
Adult↗
Treatment of patients with acute renal failure during Marmara earthquake.
Crush syndrome or traumatic rhabdomyolysis is a serious and epidemic clinical case that develops among casualties of earthquakes or other catastrophic events. Hypocalcaemia is one of the main symptoms that accompanies crush syndrome. It is essential that immediate IV volume replacement treatment be initiated for such patients, which is known to positively affect prognosis and help prevent the development of acute renal failure. Following the earthquake of 17th August 1999 in the north-west of Turkey, 333 casualties were hospitalised in the Medical Faculty of Uludag University. 60 (18%) of these patients [34 males (56.6%) and 26 females (43.4%)] received haemodialysis treatment. The average number of HD sessions received bythe patients was 48. Intermittent HD applied to 44 patients (73.3%) was the preferred method of treatment. Fluid overload and azotemia were the leading indications (76.6%) for dialysis. The lower extremities were mainly injured in these patients [33 (55%)]. Therefore, subclavian catheterisation was preferred in those patients with trauma at this site. 594 (67.1%) HD sessions were applied with limited heparin due to the risk of bleeding. Hypotension in 94 patients (61%) and thrombosis in 60 (45.7%) were the main complications. Of the complications not due to HD, infection in 23 patients (38.3%) was the most significant. 21 patients (35%) were lost during the treatment. It was thanks to the sacrifices and co-operation among national and international medical teams that the mortality rate was low.
Acute Kidney Injury↗