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Biomedical subjects

A F Buniatian

Publications and source records attributed to A F Buniatian.

At least 19 recordsLinked to original sources
PubMed1995

[The antihypertensive activity of benazepril in the long-term treatment of hypertension patients and its effect on adrenal cortical function].

Changes in arterial hypertension, heart rate and adrenocortical hormones (11-OCS, aldosteron, progestins) in the blood and 24-h urine were followed up in the course of 24-week use of angiotensin-converting enzyme inhibitor benazepril (10-20 mg once a day) in 24 patients with mild and moderate essential hypertension (EH) included in a placebo-controlled randomized study. A 2 and 24-week antihypertensive response was achieved in 75 and 71% of patients, respectively. 24-h urinary excretion of corticosteroids before the treatment was increased. After the treatment benazepril reduced excretion of 11-OCS by 42%, but not of aldosteron the levels of which decreased only within the first 2 weeks of treatment. The above trends in changes of gluco- and mineralocorticoid activity should be taken into consideration in long-term treatment of EH with inhibitors of angiotensin-converting enzyme.

Adrenal Cortex↗
PubMed1990

[Sex differences in the accumulation of estrogen receptors in nuclei of liver cells and increase of angiotensinogen concentration in the blood of rats after administration of low doses of synthetic estrogens].

The significance of sex differences in the level of estrogen receptors (ER) in hepatocytes for direct effects of estrogens in male and female rat livers was investigated. 4-5-fold increase in ER level and 20-30%-elevation in plasma angiotensinogen (AG) occurred after a single injection of 0.5 microgram of hexestrol (HE) in female and gonadectomized male rats. In male liver, where the cytosol ER content is two fold lower than that in female rats, nuclear ER level was shown to be very low and unchanged after HE injection, plasma AG also did not change. Injection of 0.5 microgram of ethinylestradiol produced similar effect. Injection of a greater dose of estrogen caused an enhancement in plasma AG level in males. The existence of sex differences in hepatic ER level seems to cause in some conditions different response of metabolic processes in male and female rat liver after estrogenization.

Angiotensinogen↗
PubMed1990

[Sex differences in the level of cytosol estrogen receptors in the rat liver].

The procedure designed for the estimation of estrogen receptors (ER) in rat liver cytosol using sodium thiocyanate was shown to be useful for differential quantification of the ER level in liver cytosol of male rats, containing the unusual estrogen-binding protein. The ER concentration in rat liver cytosol was shown to be a sex dependent feature: its content in male rats (55 +/- 4 fmol/mg of protein) was lower (p 0.001) than that in female rats (116 +/- 4 fmol/mg of protein). The differences in the ER content were revealed only after maturation and disappeared after hypophysectomy of adult rats. Gonadectomy of males performed on the 1st postnatal day or in the pre- or postpubertal period resulted in complete "feminization" of the ER content in these animals. Ovariectomy in female rats at all stages of ontogenesis did not influence the ER level in liver cytosol. It was concluded that androgens have no programming, but only a negative regulatory influence on the ER level in rats.

Animals↗
PubMed1987

[Water-electrolyte balance and plasma corticosteroid level in patients with food poisoning and salmonellosis].

Altogether 57 patients with alimentary toxoinfections of obscure etiology and 39 patients with the gastrointestinal form of salmonellosis of average gravity were examined. Two methods were employed: rehydration and incorporation of indomethacin in the therapeutic scheme. The time course of the studied indices in the patients with salmonellosis was similar to dynamic changes in the patients with alimentary toxoinfections. The incorporation of indomethacin in the therapeutic scheme brought the indices of water-electrolyte metabolism and corticosteroid secretion more rapidly to normal.

11-Hydroxycorticosteroids↗
PubMed1986

[Features of the functioning of the catecholamine and adrenocortical systems of patients with depression and different degrees of emotional tension].

The catecholamine and adrenocortical systems in 52 patients with depression were studied with regard to the degree of their emotional tension. On the basis of the clinical characteristics of the depressive syndrome the patients were divided into two groups: the stressory hyperergic type (Group 1) and the torpid hypoergic type (Group 2). Some characteristics of the studied systems proved common for both groups: they increased secretion of 11-hydroxycorticosteroids and impairment of the mechanisms of negative feedback in the regulation of adrenocortical activity, as well as a decrease in the excretion of dopamine, adrenaline, and DOPA in the presence of a relative acceleration of catecholamine inactivation. Along with the characteristics common for all the patients studied, the authors revealed a highly significant difference in noradrenaline excretion between Groups 1 and 2: it was normal in Group 1 and decreased three-fold in Group 2. The findings obtained are discussed in the light of the catecholamine hypothesis of depression development.

11-Hydroxycorticosteroids↗
PubMed1979

[Hormone and mediator content in the blood of the adrenals and in the peripheral blood in hypertension].

The concentration of the fractions of corticosteroids, aldosterone, catecholamines, and cyclic nucleotides (cAMP and cGMP) in blood of the adrenal veins and the activity of renin in blood of the renal veins were studied in 22 patients with stages IIA and IIB hypertensive disease. At the same time the content of these substances in the peripheral blood was determined and compared with the level of steroid and catecholamine excretion in the daily urine. An increase in the content of free 11 OCS and F fractions in the peripheral blood and blood of the adrenal veins was revealed in all patients examined.

11-Hydroxycorticosteroids↗