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Biomedical subjects

A F Fartushnyĭ

Publications and source records attributed to A F Fartushnyĭ.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Fatal doses and concentrations of drugs in biological objects].

Information on the lethal doses and concentrations of drugs in biological objects is essential for the diagnosis of drug poisoning. Methods for measuring the concentrations of some drugs in the blood and urine have been developed and tables of lethal doses, concentrations, and metabolism coefficients for drugs most often occurring in forensic medical practice are offered. A method for estimating the drug dose which led to a lethal outcome is suggested.

Blood Chemical Analysis↗
PubMedDate not supplied

[Chemical and toxicological studies in mushroom poisoning].

Two accessory diagnostic tables reflecting the relationship between toxic effect of mushrooms and the nature and chemical structure of toxin have been developed for improving the diagnosis of mushroom poisoning. New color tests have been developed and conditions for isolation and chromatography in a thin adsorbent layer determined. The Schiff's test is specific for Amanita phalloides. This mushroom's toxins can be detected in the viscera after the maximal survival of 50 h, other mushrooms' toxins after 26-30 h.

Agaricales↗
PubMedDate not supplied

[Forensic evaluation of the results of chemical and toxicological analysis of blood alcohol level].

According to printed research results, the endogenic level of ethanol in blood amounts to 0.001-0.3%, the physiological level amounts to 0.01-0.4% and the lethal level amounts to 3-17.6%. It was established experimentally that the absolute lethal level of ethanol in blood does not exceed 15%. Criteria of incidental contamination of analyzed blood sample with ethanol are described.

Alcoholic Intoxication↗
PubMedDate not supplied

[Forensic medical diagnostics of nitrate and nitrite intoxication].

Nitrates and nitrites, accumulating in toxic concentrations in soil, plants, water and foodstuffs, can cause lethal intoxication. The method of isolation, identification and quantitation has been elaborated for their diagnosis. It is based on the isolation of water and subsequent chromogenic test plus photoelectrocolorimetry.

Forensic Medicine↗
PubMedDate not supplied

[Detection of reladorm and donormil in forensic-medical examination of cadavers].

A method was suggested for identifying reladorm and donormil in pharmaceutical drugs and biological objects. The above substances are isolated by 96% ethanol or by mixture of chloroform and isopropanol. 7 color reactions, 3 microcrystalloscopic reactions and chromatography in thin sorbent layer are suggested for identification.

Barbiturates↗
PubMedDate not supplied

[The detection of abortion agents in biological material].

Methods of extraction and detection of ascorbic acid, ergot alkaloids, cotarnine, microfollin, tinctures of marigold, peony, sage-brush, iodine, benzestrol, pachycarpine, hexestrol, folliculin, quinine, ethoxydiaminoacridine lactate were developed. Detection limits are 0.1-1 mg/100 g of object. Methods of manganese, iodine and soap detection are developed. Detection limits are 0.05-2 mg/100 g of object.

Abortifacient Agents↗
PubMedDate not supplied

[The detection of aromatic substances in biological material].

The author presents experimental data and suggests a method for extraction of aromatic substances from the blood, urine, lavage water, stomach and its contents, liver and kidneys. The extract is dissolved in 96% ethanol and the aromatic substances are detected in reactions with hydrochloric acid, Marki's reagent, 2,4-dinitrophenylhydrazine, diazotized o-dianisidine, phthivazide, chromotropic acid by UV spectrophotometry, thin-layer and gas-liquid chromatography. The sensitivity of the method is 0.1-0.5 mg %.

Body Fluids↗
PubMedDate not supplied

[The detection of tubazid and saliuzid metabolites in internal organs and biological fluids].

Detection of tubaside and saluside metabolites by methanol extraction from homogenized object with subsequent investigation by UV spectrophotometry, microcrystalloscopy, thin-layer chromatography and coloured reaction methods is suggested. Sensitivity for hydrazine, acetylisoniazid was 0.1 mg%, for opianic and isonicotinic acids--0.05 mg%.

Antitubercular Agents↗
PubMedDate not supplied

[The forensic chemical determination of antidiabetic agents].

Method of detection, purification and determination of some antidiabetic agents (ADA)--bucarban, butamid, glybenclamid, glybutide, methformine, prediane, chlorpropamide, chlocyclamide, cyclamide in biological material was developed. Microcrystalline reaction with 10% alcoholic potassium iodide, colour reactions and investigation by TLC method both native substances and nitration products were developed to identify ADA. The assay is performed by spectrophotometry. Detection limit is 2-5 mg of each substance in 50 g of the material.

Chromatography, Thin Layer↗