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Biomedical subjects

A F Haenel

Publications and source records attributed to A F Haenel.

11 recordsLinked to original sources

[Iodine supply at various periods in life and ultrasonographic thyroid volume in school children in a region of Switzerland].

In Switzerland the previous severe iodine deficiency has been corrected by iodization of salt. Changing food habits make it mandatory to periodically monitor iodine intake. In 1994 we therefore measured thyroid volume by sonography in 217 schoolchildren, and iodine, creatinine and sodium in casual urine samples of 214 schoolchildren, 40 pregnant women and 30 breast-fed newborns. Iodine was also measured in 30 breast milk samples. In schoolchildren, goiters of WHO grades Ia/Ib/II were found by palpation in 10.6/2.3/ 0.9%. By contrast, only two of the children had a sonographic thyroid volume exceeding the 97 percentile of the WHO, which underlines the difficulty of estimating the size of small goiters by palpation. Mean thyroid volume at 6/7/9/ 10/11 years of age was 2.1/2.2/3.3/3.3/3.1 ml, which is well within the normal range suggested by the WHO. Mean urinary iodine in schoolchildren (118 +/- 49 micrograms per gram creatinine) and in pregnant women (193 +/- 113 micrograms per gram creatinine) is within required limits, albeit with a decrease since 1988. In breast milk (7.8 +/- 5.9 micrograms/dl) and in urine of newborns (6.6 +/- 3.3 micrograms/dl) iodine values are below the Swedish reference values but well above values found in iodine deficient areas. We conclude that the iodine supply in schoolchildren and pregnant women is just sufficient and in newborns slightly below recently recommended limits. Compared to 1988 the iodine supply to schoolchildren is diminishing. The discrepancy between the rather low iodine content in breast milk despite a normal iodine supply during pregnancy remains to be explained.

Breast Feeding↗

[Perinatal risk in significant macrosomia. A study based on the databank of the Professional Society of Swiss Gynecologic Clinics 1983-1992].

A comparison of a group of births with severe macrosomia with a group of normal birth weight was made based on the data from the "Arbeitsgemeinschaft schweizerischer Frauenkliniken" (ASF), a work group of Swiss departments of obstetrics and gynaecology. During the period from 1983 to 1992 there were 2911 births of infants weighing more than 4500 g and 222,336 births of infants weighing between 3000 and 4000 g. Overall, the births of the macrosomic infants were more difficult, the rates of secondary Caesarean sections higher and the fetal outcomes poorer. The rates of shoulder dystocia, fracture of clavicle and palsy were higher. Only the last three complications were dependent on the mode of birth. In order to avoid, at least partially, palsy as the most serious of the complications of shoulder dystocia, it has been proposed to perform primary Caesarean section whenever the estimated birth weight is over 4500 g. Indeed, in our study, a part of the palsies had not occurred if all newborn weighing more than 4500 g had been delivered by Caesarean section. However, due to the difficulty in estimating the birth weight in utero, the high occurrence of spontaneous recovery from palsy and the high incidence of palsy in the comparison group, we could not find a clear proof of the necessity to perform primary Caesarean sections of all infants having estimated birth weights of over 4500 g.

Adolescent↗

[Routine measurement of the biggest amniotic fluid pocket in the 3d trimester: prognostic significance?].

The largest pocket of amniotic fluid was measured routinely during the last trimester of pregnancy in 577 patients representing risk and nonrisk cases. The measurements were performed at two clinics between 26 and 42 weeks of gestational age. A statistically significant relationship between a value of less than 30 mm and the following perinatal parameters was found: 5-min Apgar score less than 7, umbilical cord blood pH values less than 7.15, severe neonatal complications, intrauterine growth retardation, perinatal mortality. The good predictive value of decreased amniotic fluid measured by the largest pocket, and the simple practicability of the method raise the question whether the largest pocket of amniotic fluid should not be assessed routinely at each ultrasound examination during the last trimester. The consequences of a decreased value are discussed.

Amniotic Fluid↗

[Chorionic villi (placental) biopsy in the 2d and 3d trimester: new perspectives in prenatal diagnosis].

A report of our first experience in second and third trimester chorionic villus (placental) biopsy is given. In all 16 cases a cytogenetic result could be received within 2 to 5 days. There were 6 normal female and 9 normal male karyotypes. A third trimester CVS showed a mosaicism of a structural aberration of chromosome 9 (46, XX/46, XX, 9p+). Blood cultures of the fetus revealed a normal female karyotype. The following indications of a second and third trimester CVS are discussed: direct or indirect signs of fetal malformations in ultrasound scanning (Oligo- or Anhydramnios with severe intrauterine growth retardation), placental anomalies (exclusion of triploidies), non immunologic hydrops fetalis, low serum alpha FP and failed amniotic fluid culture. We believe that transabdominal CVS in the second and third trimester is a simple and rapid tool to exclude distinctively any chromosomal anomaly and therefore influences further management of pregnancy and parturition.

Biopsy↗

[Hemodialysis--the arteriovenous fistula, distal to the wrist joint].

The arterio-venous fistula distal to the proc. styloides radii in the "tabatière" offers a most useful additional and very peripheral vascular access for chronic hemodialysis. It in no way compromises the further construction of arteriovenous anastomoses in be forearm in fistula failure. The results of 26 such fistulas are reported.

Arteriovenous Shunt, Surgical↗

[The postpartum course of the HCG titer of maternal blood and its clinical relevance].

In 62 postpartum patients serial beta-HCG-measurements were performed. These tests show that beta-HCG should disappear entirely during the third week postpartum. Significant titers beyond this time are seen when placental tissue remains in utero. This condition may lead to late postpartum hemorrhage which is best treated by curettage. If there is only mild bleeding and beta-HCG-titers are negative, a hormonal curettage with subsequent estrogen administration (3 weeks) can be performed. In doing so, unnecessary and potentially harmful intrauterine manipulations can be avoided.

Chorionic Gonadotropin↗