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Biomedical subjects

A F Hegyeli

Publications and source records attributed to A F Hegyeli.

At least 19 recordsLinked to original sources
PubMed1986

Synthesis and bioevaluation of alkyl 2-cyanoacryloyl glycolates as potential soft tissue adhesives.

A series of alkyl 2-cyanoacryloyl glycolate tissue adhesives were synthesized and characterized by NMR. Physical properties and bond strengths are presented. Within the series, bond strength decreased with increasing molecular weight. Corresponding polymers were evaluated by in vitro and in vivo techniques for biocompatibility. In general, in vitro biocompatibility increased with molecular weight. Based on in vitro and in vivo results, the isobutyl and isoamyl derivatives gave polymers that were most biocompatible, however, the entire series was found to be less reactive than poly(methyl 2-cyanoacrylate) and only the isopropyl derivative polymers more reactive than poly(isobutyl 2-cyanoacrylate). Approximately one-third of the isobutyl polymer biodegraded in vivo after 6 weeks.

Adhesiveness↗
PubMed1986

Synthesis and bioevaluation of a rapidly biodegradable tissue adhesive: 1,2-isopropylidene glyceryl 2-cyanoacrylate.

A rapidly biodegradable tissue adhesive, 1,2-isopropylidene glyceryl 2-cyanoacrylate, was synthesized and characterized by NMR. Bond strength was determined. Three types of corresponding polymers were prepared and evaluated for in vitro and in vivo toxicity. The polymers were generally found to be in the moderately toxic and toxic groups similar to the lower alkyl 2-cyanoacrylates.

Adhesiveness↗
PubMed1978

Biocompatibility testing of polymers: in vitro studies with in vivo correlation.

An in vitro method has been developed for screening of candidate biomaterials in an early phase of their development. The test is based on L-929 mouse fibroblast cultures and their response to powdered polymer samples. It applies microscopic observation for the detection of morphological changes, uses dye exclusion testing for cell viability determination, and utilizes estimation of population doublings as an end point. The test is shown to be reliable and reproducible and is compared to in vivo implantation studies in rats, previously reported.

Animals↗
PubMed1978

Biocompatibility testing of polymers: in vivo implantation studies.

An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The methods is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.

Animals↗
PubMed1976

Specimen holders for simultaneous critical point drying of multiple biological specimens.

Specimen holders were developed for simultaneous critical point drying of multiple specimens of monolayer cell cultures grown on Leighton tube glass cover slips or for specimens of cells collected on silver or cellulose membrane filters. The use of these multiple specimen holders makes it possible to process several specimens in parallel and thus significantly reduce the time required for handling large numbers of samples and also eliminate the possible variations that occur in processing individual samples one at a time in series.

Cells, Cultured↗
PubMed1975

Physical characteristics and performance of synthetic wound dressings.

From these studies it is concluded that: 1) Physical characteristics of wound dressings can be quantified and evaluated for their contribution to in vivo performance. 2) A total performance scoring system can be reliably used to quantitatively separate series of wound dressings by their in vivo performances. 3) The physical characteristics most determinate of good perfprmance in these 5 series of dressings were undersurface texture and water vapor transmission.

Animals↗