Invasive tracheobronchial aspergillosis in an F344/N rat.
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A F Hubbs
Publications and source records attributed to A F Hubbs.
Epithelial progenitor cells in the rat trachea.
Highly pure populations of basal and secretory cells from the rat trachea have been inoculated into denuded tracheal grafts to determine the differentiation pathways of these two cell types. The basal cell inoculum resulted in an epithelium comprised of only basal and ciliated cells, while the secretory cell inoculum gave rise to an epithelium comprised of secretory, basal, and ciliated cells. These results show that, in the rat trachea, the secretory cell is the major progenitorial cell type and the basal cell has only limited progenitorial capacity.
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Increased resistance to transforming growth factor beta accompanies neoplastic progression of rat tracheal epithelial cells.
Transforming growth factor beta (TGF beta) is an inhibitor of normal epithelial cell growth. To investigate the role of TGF beta in respiratory epithelial cell neoplasia, normal, preneoplastic, tumorigenic and tumor-derived rat tracheal epithelial (RTE) cells were plated in serum-free medium and grown in the presence of 0-300 pg TGF beta 1/ml. TGF beta 1 markedly inhibited the formation of colonies by primary RTE cells and some preneoplastic RTE cells. However, tumor-derived RTE cells were relatively resistant to TGF beta 1-induced growth inhibition. Resistance to TGF beta 1-induced growth inhibition, therefore, accompanies neoplastic progression of RTE cells.
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