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Biomedical subjects

A F Kaliberdina

Publications and source records attributed to A F Kaliberdina.

11 recordsLinked to original sources
PubMedDate not supplied

[The immunological factors characterizing neurochorioretinitis].

Comprehensive clinical and immunologic studies carried out in 38 patients with neurochorioretinitis have demonstrated the contribution of infection to the etiology and pathogenesis of this condition and helped identify the nature, mostly infectious, of the condition in 55.3% of patients. Toxoplasma infection, revealed in 39.5% of cases, is one of the major etiologic factors of neurochorioretinitis. Tuberculous etiology of the condition is more rare (7.9% of cases). The autoimmune systemic component was detected in 7.9% of the examinees. Immunopathologic shifts, presenting as hyperimmunoglobulinemia, were fairly frequent (71.9% of patients), excessive concentrations of circulating immune complexes were detected in 78.6% and cryoglobulins were found in 42.9% of the examinees, this permitting the authors to regard neurochorioretinitis as a form of immunocomplex conditions of the eye, most possibly, of an infectious origin. Blood group A (II) was found to be a risk factor for neurochorioretinitis patients; according to the literature data, this is explained by a reduction of the interferonogenic activity. Etiotropic anti-inflammatory drugs, including corticosteroids, and interferon preparations for the risk group patients appear to be advisable for the therapy of neurochorioretinitis.

ABO Blood-Group System↗
PubMedDate not supplied

[Immunologic disorders in patients with idiopathic subretinal neovascular membrane].

The authors analyze the results of comprehensive clinical and immunologic examinations of 52 patients with this condition (SNVM) in its active and inactive phases, angiographically confirmed, aged 19 to 46; 32 of these were women (61.5%), 20 (38.4%) men. A complex of immunologic methods was employed to reveal the etiology of the condition and the immune status of SNMV patients. The origin of the condition was identified in 44.2% of patients; it was toxoplasmic in 19.2, autoimmune in 15.4, tuberculous in 7.7, and mixed toxoplasmic and tuberculous in 1.9% of cases. T lymphocyte functional activity was inhibited in 37.5% of patients with the exudative hemorrhagic phase of SNMV and in 16.7% of those in the cicatrization phase. Changes in the humoral immunity presenting as gammapathies were detected in 34% of patients, those manifesting by hyperconcentrations of circulating immune complexes in 66.7%, and of cryoglobulins in 37.8% of patients. Krypton laser coagulation was employed in multiple-modality treatment of patients with SNMV. The remissions persisted for 3-5 years.

Adult↗
PubMedDate not supplied

[Immunologic disorders in young patients with retinal vein thrombosis].

Immunologic shifts in 53 patients with retinal vein thrombosis, aged 20 to 41, were under study. Present-day immunologic methods were employed to investigate the status of the humoral and cellular immunity and define the infection rate. The results were assessed functionally and immunologically. The authors have revealed the contribution of infection to the development of retinal vein thrombosis in young patients, analyzed for the first time the immunity status of such patients, detected the signs of humoral immunodeficiency are senting as gammapathies and impaired complex formation, showed the relationship between thromboses and genetic predisposition and the role of the erythrocytic phenotype in the development of a cyst-like edema; this permitted them develop recommendations on the disease source and outcome prediction and on the choice of drugs.

Adult↗
PubMedDate not supplied

[Hemosorption in multimodal treatment of endogenous uveitis].

Hemoperfusion was used in multiple modality treatment of 92 patients with chronic recurrent endogenic uveitis and uveitis associated with syndromic conditions. The treatment included systemic and local steroids, and antiinflammatory therapy. Clinical improvement was achieved in 75 percent of patients; it was paralleled by improvement of the vision acuity. In the rest patients vision acuity was unchanged because of irreversible impairment of the retina and optic nerve, but uveitis ceased. Addition of hemoperfusion of multiple-modality treatment of uveitis patients resulted in shortening of hospital stay by 6-7 days, in prolongation of remission periods to 10-15 months after a single course of hemoperfusion in 71 percent of patients and after two courses in the rest. A dynamic immunologic analysis has shown normalization of T lymphocyte functional activity, and of blood serum immunoglobulin and circulating immune complexes levels.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Clinical pre-laboratory diagnosis of immune deficiency in diseases of the vascular coating and retina].

The authors analyze the results of prelaboratory diagnosis of immunologic insufficiency in 948 patients with various clinical forms of endogenic uveitis and retinovasculitis; the diagnosis was based on the totality of clinical signs and ther combinations, summed up in a universal diagnostic chart developed at the Institute of Immunology of the RSFSR Ministry of Health. Immunologic insufficiency was diagnosed in 67.5 percent of uveitis patients mainly in the presence of infectious or autoimmune syndromes developing, as is well known, in depression of T cellular immunity. This is practically valuable for the development of pathogenetic treatment of these grave patients, whose multiple-modality treatment should include immunostimulants and immunomodulators.

Adolescent↗
PubMedDate not supplied

[Involvement of the eyes in yersiniosis].

The results of clinical examinations of 15 patients with yersiniasis are analyzed. Besides the involvement of the anterior segment of the eye, known before, the authors have detected for the first time 3 cases of the fundus oculi involvement; the impairments resemble multiplaquoid epitheliopathy. The clinical description is supplied with fluorescent angiograms. Yersiniasis is regarded as a possible etiologic factor responsible for multiplaquoid epitheliopathy; this extends the scope of our knowledge on the etiological structure of the fundus oculi impairments.

Conjunctivitis↗
PubMedDate not supplied

[Changes in T-lymphocyte subpopulations in uveitis].

Examinations of 30 patients with uveites, carried out by the method developed by Moretta et al., have revealed changes in T-lymphocyte subpopulations, mainly of the immunodeficiency type, with the reduction of the total T-lymphocyte count in 53.3% of patients and a significant decrease of the T mu/T gamma coefficient in 60% of patients. Stage II immunodeficiency status has been diagnosed in the majority of patients with generalized and anterior uveites. Stage II T-helper deficit has been most frequently detected in uveites coursing for 1-3 years with an exudative hemorrhagic component. The detection of the types and variant of immunoregulatory lymphocyte disorders helps choose the treatment strategy, including immunocorrecting drugs.

Adolescent↗