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A F Lauritzen

Publications and source records attributed to A F Lauritzen.

30 records · Page 2Linked to original sources
PubMed1989

[Carcinoma of the urachus].

The urachus is an embryological structure originating from the allantois and situated in Retzius' space. Neoplasms originating from the urachus are very rare. They become clinically manifest late in the course of the disease. Deformation of the apex of the bladder and supravesical calcifications are described as radiological findings but these are of limited diagnostic value and should be supplemented by ultrasonic scanning, computed tomography and possibly by magnetic resonance scanning which will provide information about the extent of the disease. The final diagnosis is based on the macroscopic findings and the macroscopic picture. Three cases representing various aspects of the disease are presented. Treatment consists of en bloc resection in the form of partial cystectomy and excision of the tissue in Retzius' space and the umbilicus. The results are, however, disappointing as the five-year survival rates in the majority of materials do not exceed 10%. Irradiation is of doubtful value and chemotherapy is scarcely of value in the treatment.

Adenocarcinoma↗
PubMed1989

Diagnosis of acute myeloid leukaemia with the use of monoclonal anti-neutrophil elastase (NP57) reactive with routinely processed biopsy samples.

The reactivity of a monoclonal anti-neutrophil elastase antibody (NP57) with routinely processed biopsy samples from various acute leukaemias has been examined and compared with that of chloroacetate esterase and CD15 (hapten X), two other myeloid cell-associated markers detectable in paraffin sections. No staining was seen with these markers in 14 cases of acute lymphoblastic leukaemia. In contrast the neoplastic cells in 27 of 37 acute myeloid leukaemias were NP57 positive. Twenty of these were also positive for chloroacetate esterase, whereas CD15 was expressed in only six cases. These results indicate that detection of elastase with monoclonal NP57 forms a useful supplement to traditional methods for the histopathological diagnosis of acute myeloid leukaemias.

Antibodies, Monoclonal↗
PubMed1989

Diagnostic value of monoclonal antibody B72.3 in detecting adenocarcinoma cells in serous effusions.

In serous effusions, the cytologic diagnosis of adenocarcinoma, and its distinction from mesothelial hyperplasia and malignant mesothelioma, is still difficult. This study compares the immunoreactivity of antibody B72.3 with that of anti-CEA, anti-LeuM1-antigen and anti-keratins in 41 serous effusions from patients with different malignant disorders. B72.3 selectively stained adenocarcinoma cells in 80% of the cases and was as good as anti-CEA and superior to anti-LeuM1-antigen and anti-keratins. It is concluded that B72.3 forms a useful supplement to conventional cytomorphology in the distinction between adenocarcinoma cells, reactive mesothelial cells and malignant mesothelial cells in serous effusions.

Adenocarcinoma↗
PubMed1988

A comparative study of transitional cell tumors of the bladder and upper urinary tract.

In two groups composed of 228 patients with bladder tumors and 37 patients with upper urinary tract (UUT) tumors, we compared the transitional cell carcinoma in respect to sex, age, grade of dysplasia, staging, and survival. No differences could be established between the two groups, and we found the same 5-year survival rates of approximately 26% and 29%, respectively, for the invasive carcinomas.

Carcinoma, Transitional Cell↗
PubMed1988

Relationship between blood groups and tumors of the upper urinary tract.

Comparing the relationship between upper urinary tract tumors and blood group ABO and the rhesus system showed that patients with blood group A and blood type rhesus positive had more invasive tumors with a higher grade of dysplasia than patients with blood group O and blood type rhesus negative.

ABO Blood-Group System↗
PubMed1987

Distinction between cells in serous effusions using a panel of antibodies.

In serous effusions the distinction between reactive mesothelial cells and malignant cells (especially adenocarcinoma cells and malignant mesothelial cells) is frequently a cause of diagnostic difficulty. The present paper describes the immunocytochemical staining of cells in 76 effusions from 71 patients with different malignancies. In 91% of the effusions obtained from patients with adenocarcinomas, the cells stained positive for anti-EMA, 94% for anti-CEA, 64% for anti-LeuM1-antigen and 75% for anti-keratins. In more than 90% of the cases the reactive mesothelial cells stained positive for anti-keratins, but not for anti-EMA, anti-CEA or anti-LeuM1-antigen. It is concluded that a panel of the antibodies against EMA, CEA, LeuM1-antigen and keratins is valuable in the distinction between adenocarcinoma cells, malignant mesothelial cells and reactive mesothelial cells in serous effusions.

Adenocarcinoma↗
PubMed1987

Primary carcinoma of the upper urinary tract.

Thirty-seven patients with upper urinary tract tumours were evaluated for grade, stage, histological type, location, presence or absence of vascular invasion, abnormalities in the urothelium adjacent to the tumours, tumour multiplicity and patient survival. A good correlation between tumour grade and stage was found in the transitional cell tumours. Squamous cell carcinomas and adenocarcinomas were high-stage tumours. Vascular invasion was present in most high-grade tumours, squamous cell carcinoma and adenocarcinomas. Four patients had multifocal tumours of both pelvis and ureter. Three developed ureteric stump carcinomas and 13 had further development of bladder carcinomas. The cumulative 5 and 10 year survival rates were 43 and 23% respectively.

Adenocarcinoma↗
PubMed1987

Isolated arteritis of the uterine cervix.

Isolated arteritis has the same histological picture as polyarteritis nodosa but affects the arteries of one organ only. Two cases in the uterine cervix are reported and a brief review of the features is given.

Adult↗
PubMedDate not supplied

Influence of prefixation and fixation times on cellular preservation and epithelial cellularity in filter imprints.

Cells from malignant and nonmalignant lesions of the breast were suspended in three different fixatives or in a balanced electrolyte solution (Hank's), stored for varying periods of time, collected on Millipore filters and then imprinted on to clean microslides in order to evaluate the influence of prefixation and fixation time on epithelial cellularity and cellular preservation. The use of a methanol-acetic acid fixative (Esposti's fixative) or 50% isopropanol resulted in good preservation whereas cells prefixed in formaldehyde or 100% isopropanol were poorly preserved. Cells that had not been prefixed (suspended in Hank's solution) showed fair preservation. Eighty-eight percent of the imprints prepared from suspensions of Esposti's fixative were highly cellular, which was significantly better than with Hank's solution (68%), 50% isopropanol (66%), 100% isopropanol (56%) and formaldehyde (33%). The cellularity of the formaldehyde-prefixed imprints differed significantly from the others. There was no influence of storage time on either cellular preservation or epithelial cellularity for any of the investigated solutions.

Breast Neoplasms↗