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Biomedical subjects

A F Mabadeje

Publications and source records attributed to A F Mabadeje.

33 records · Page 2Linked to original sources
PubMed1980

A controlled trial of a combination of chloroquine with paracetamol in the treatment of acute malaria in a semi-immune population.

A clinial trial comparing a single dose of a fixed drug combination containing chloroquine and paracetamol with chloroquine and paracetamol given as separate tablets has been conducted among 154 patients seen in the Endemic Disease Clinic of the Lagos University Teaching Hospital and at two other clinics in Nigeria. There was no statistically significant difference in the preference between the different types of prescription among the sujects in the two groups. However, a greater degree of parasite clearance was achieved sooner in those who received the fixed drug combination taken in a single or in only two doses than among those whose therapy extended over 3 days or longer using separate tablets of chloroquine and paracetamol.

Acetaminophen↗
PubMed1976

Aerosol beclomethasone in steroid dependent asthmatics.

Aerosol beclomethasone dipropionate was effective in maintaining airway patency in 14 out of 16 steroid-dependent asthmatics. In 3 patients who had significant adrenal suppression on systemic corticosteroid therapy substitution with aerosol beclomethasone led to recovery of adrenal function. From the evidence obtained it is concluded that this aerosol steroid represents a modest advance in the therapy of asthma.

Administration, Inhalation↗
PubMed1976

An open trial of prazosin in the treatment of hypertension.

An open trial of prazosin has been conducted among 18 males aged 18-68 years (mean 42.7) and 22 females aged 23-70 years (mean 47.5) seen at the Lagos University Teaching Hospital Hypertension Clinic. 3 suffered from mild to moderate hypertension and 9 suffered from severe hypertension. The dose employed ranged from 2 to 60 mg per day in 2 or 3 divided doses. All 6 patients whose placebo diastolic pressure was below 100 mm Hg gave excellent response. 19(76%) of the 25 patients whose placebo diastolic pressure ranged from 100 to 114 mm Hg gave excellent response. Only 3 to 9 patients whose placebo diastolic pressure ranged from 115 to 129 mm Hg gave excellent response. There was improved response when polythiazide 2 mg daily was added to the treatment. The total number giving excellent response increased from 28 (70%) to 36 (90%). In 3 cases (7.5%), the response was fair and one case (2.5%) remained poor. In most cases there was slight increase in pulse rate. The side effects encountered included palpitation in 8 patients 3 of whom also had postural hypotension. There were no biochemical or haematological abnormalities caused by prazosin but on continued therapy 16 patients developed tolerance to its effect. Thus prazusin has been found to be useful addition to the antihypertensive arm amentarium.

Adolescent↗
PubMed1975

Fenfluramine-associated hypertension.

Fenfluramine is a recently introduced anorexigenic drug for the treatment of obesity. 5 cases of hypertension induced or aggravated by fenfluramine are described. They include 4 females and one male seen and followed in the Hypertension Clinic of the Lagos University Teaching Hospital. Even though there was loss of weight while they were on fenfluramine there was a rise in blood pressure in 4 of them despite concurrent therapy with antihypertensive agents. In one female patient the rise in blood pressure occurred while on self-medication with the drug alone. In all of them the blood pressure fell when fenfluramine was stopped. Although there have been many reports of the effectiveness in the treatment of obesity, reports of its adverse reactions have been few and there has been no mention of hypertension. The drug brochure warns that hypotension may even occur. In view of the present case reports it is advisable that those who are on fenfluramine should have their blood pressure checked regularly particularly if they are also known to be hypertensive.

Adult↗
PubMedDate not supplied

Time-dependent inhibition of theophylline elimination by erythromycin stearate.

The effect of erythromycin stearate at a dose of 1 g daily on theophylline disposition was studied in six healthy adult males. The mean value of 5.46 h for the theophylline half-life after 48 h pretreatment with erythromycin stearate was not significantly different from the control value of 5.24 h. The half-life value of 8.48 h after a 1-week course of the antibiotic, however, represented a significant increase (p less than 0.005). Theophylline disposition 1 week after the last dose of the antibiotic was not significantly different from the control. It is suggested that therapeutic doses of erythromycin stearate for a week or more could impair the disposition of concurrently administered theophylline. The impairment however, is reversible, being absent a week after the last antibiotic dose.

Adult↗
PubMedDate not supplied

WHO-ISH Guidelines for the management of hypertension: implementation in Africa--the Nigerian experience.

A 1990-91 country-wide survey in Nigeria showed the prevalence of hypertension to be 11.2% in those aged 15 years and above. The management, however, has been shown to be inadequate. At the instance of the Nigerian Hypertension Society a Consensus Meeting of National Medical Societies and other interest groups produced in 1996 Guidelines for the Management of Hypertension in Nigeria. Medical societies and the pharmaceutical industry have tried to increase awareness of the condition and its control through lectures, seminars, sponsor of essay competitions among secondary school and university students as well as canvassing against cigarette advertising and smoking in public places. However, their efforts are thwarted by luring advertisements by multinational tobacco companies driven from developed countries by anti-tobacco lobbies and legislation. A questionnaire survey showed that no other African country had produced similar guidelines in the past five years. In Sub-Saharan Africa there appears to be negligible implementation of the WHO-ISH Guidelines.

Adolescent↗
PubMedDate not supplied

Effect of diabetes mellitus on glomerular filtration rate in an urban hospital diabetic population.

Glomerular filtration rate (GFR) as assessed by endogenous creatinine clearance was studied in 46 male and 38 female patients with diabetes mellitus (DM). Of these, 44 patients had uncomplicated DM (Group I) whilst 40 patients had complicated DM (Group II). There were 20 insulin-dependent diabetes mellitus (IDDM) patients in Group I and 5 in Group II, and 24 non-insulin dependent diabetes mellitus (NIDDM) patients in Group I and 35 in Group II. In Group I, 6 IDDM and 4 NIDDM patients had supranormal glomerular filtration rate (creatinine clearance 125 ml/min) and in Group II 1 IDDM and 6 NIDDM patients had supranormal GFR. The presence of diabetic complications and the mode of therapy of the diabetic state did not significantly affect the glomerular filtration rate. This concludes that glomerular hyperfiltration occurred in both IDDM and NIDDM Nigerian patients.

Adolescent↗