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Biomedical subjects

A F Miasoedov

Publications and source records attributed to A F Miasoedov.

7 recordsLinked to original sources
PubMedDate not supplied

[Early radiation-induced toxemia and effectiveness of its correction with aminodez and gluconeodez].

The experiments on irradiated rats (LD90/30) and dogs (LD70/45) have shown that three administrations of aminodez or gluconeodez in a dose 10 mg/kg (3, 24 and 48 hours after the exposure) lowered radiotoxins levels (malonic dialdehyde, middle-molecular peptides), promoted stabilization of cellular membranes, enhanced activity of the body's detoxicating systems. In irradiated rats early detoxicating therapy with aminodez and gluconeodez raised survival by 40%.

Animals↗
PubMedDate not supplied

[Experimental study of therapeutic efficacy of plasmapheresis in acute radiation injury].

In experiments with dogs exposed to 2.9 Gy (LD80/45) it was found that plasmapheresis treatment 4-6 h after irradiation reduce the severity of the radiation sickness clinical manifestations and post-radiation toxemia thus increasing the rate of animal survival up to 60%. Sham plasmapheresis included all the manipulations of plasmapheretic treatment except plasma substitution and had no detoxication effect and did not affect the irradiated animals survival. This is evidence for leading role of detoxication in the mechanisms of the therapeutic action of plasmapheresis in acute irradiation.

Acute Disease↗
PubMedDate not supplied

[Clinical and experimental investigation on the radioprotective effect of riboxine in low-dose fractionated irradiation].

In experiments with dogs (fractionated y-irradiation, accumulated dose 1Gy) as well as in clinical testing of the group of men, recieved 0,25 Gy being engaged in the Chernobyl NPS disaster repairment, the positive influence of riboxin (purine nucleoside) course treatment on parameters of peripheral blood and non-specific resistance system has bee n shown.

Animals↗
PubMedDate not supplied

[The effect of cystamine on the level of postradiation peroxidation products in the lymph of dogs].

The experiments on irradiated dogs with a drained pectoral lymph duct revealed an early accumulation of radiotoxins (diene conjugates and malonic dialdehyde) in the lymph and blood plasmas and; simultaneously, a lowering of water-soluble antioxidants. The prophylactic application of cystamine improved the drain-detoxifying function of the lymphatic system, lowered the level of radiotoxins, and aided in the antioxidant properties of lymph and blood plasmas.

Animals↗