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Biomedical subjects

A F Popov

Publications and source records attributed to A F Popov.

At least 19 recordsLinked to original sources
PubMed2006

Influence of eNOS gene polymorphisms (894G/T; - 786C/T) on postoperative hemodynamics after cardiac surgery.

BACKGROUND: Differences in vascular reactivity have been associated with variable NO release due to 894G/T and -786C/T polymorphisms of the eNOS gene. Carriers of the 894T and -786C alleles are known to have enhanced vascular responsiveness to vasoconstrictor stimulation due to decreased NO generation. Thus, we hypothesized that eNOS gene polymorphism could influence perioperative hemodynamics and catecholamine support in patients undergoing cardiac surgery with CPB. METHODS: In 105 patients undergoing elective CABG with CPB, systemic hemodynamics, cardiac index (CI), systemic and pulmonary vascular resistance indices (SVRI, PVRI) and catecholamine support were measured at baseline and 1 h, 4 h, 10 h and 24 h after CPB. Genotyping for the 894G/T and -786C/T eNOS gene polymorphisms was performed by polymerase chain reaction amplification. Patients were divided according to their genotype (894G/T: GG=group 1, GT and TT=group 2; -786C/T: TT=group 3, CT and CC=group 4). RESULTS: Genotype distribution for 894G/T polymorphism was 41% (GG), 52.4% (GT), 6.6% (TT) and for -786C/T polymorphism 37.1% (TT), 41.9% (CT) and 21% (CC). Pre- and intraoperative characteristics and systemic hemodynamics did not differ between groups. CI, SVRI and PVRI remained unaffected by genotype distribution. Statistical analysis of postoperative data revealed no difference between groups, especially for pharmacologic inotropic or vasopressor support. Also, coexistence of the 894T and -786C alleles had no impact on perioperative variables compared to homozygous 894G and -786T allele carriers. CONCLUSIONS: In contrast to current suggestions, the 894G/T and -786C/T genetic polymorphisms of the eNOS gene do not influence early perioperative hemodynamics after cardiac surgery with CPB.

Aged↗
PubMed2005

[The cytokine profile in patients with chronic type C hepatitis].

The purpose of the study was to perform complex evaluation of cytokine status in patients with type C chronic hepatitis (CCH), taking into account its system and local parameters and their correlation with peculiarities of clinical and morphological parameters. The study revealed a significant increase of concentrations of cytokines Th-2, interleukins (IL-4, IL-10), and proinflammatory cytokines (IL -1alpha, IL -12p40, IL -12p70), as well as a significant decrease of Th1-cytokine (IL-2 and interferon-gamma) levels, both in blood and in the supernatant of hepatic tissue samples. The study also found an increase of serum and local tumor necrosis factor (TNF) -alpha and established a correlation between the levels of the system and local cytokines under study, on the one part, and clinical, laboratory and morphological parameters, on the other, which evidences their significant role in CCH immunopathogenesis. The most significant from the clinical point of view are serum and local levels of TNF-alpha, IL-4, IL-12p40; the most important parameters for determination of inflammatory activity of the pathologic process and fibrosis stage are concentrations of IL-4, IL-10, and IL-12p70 in serum and the supernatant of hepatic tissue samples.

Adolescent↗
PubMed2004

[Diagnosis of tropical malaria by express-methods].

An examination of a thick blood drop and of blood smear for the presence of plasmodia is a classic and indisputable diagnostic test for tropic malaria. However, express-methods, based on the immune-enzyme analysis, have been introduced into the health-care practice primarily in developing and underdeveloped countries. The diagnosis of tropic malaria by using the discussed methods enables, in the non-laboratory settings, a rapid and reliable detection of PI. falciparum in blood. This is important because an untimely diagnosis of tropic malaria increases the risk of the lethal outcome.

Animals↗
PubMed2003

[Modern treatment of malaria].

Ineffectiveness of malaria treatment is in many cases explained by chloroquine resistance (CR) of plasmodia (CRP) which dominates in some regions of Africa and South-East Asia. The authors present their experience in malaria treatment obtained during many years, analyse malaria treatment by new antimalaria drugs in "non-immune" persons temporarily living in endemic regions.

Animals↗
PubMed2000

[Clinical significance of cellular and humoral immunity in tropical malaria].

Humoral and cellular immunity were studied in 34, 59 and 21 patients with mild, moderate and severe tropical malaria in the course of the disease. It was found that immunological indices in tropical malaria change with the disease severity. Some immunological indices may be indicative of the infection severity, outcome and prognosis of the disease and contribute to more effective chemotherapy and immunocorrection.

Adult↗
PubMed1996

[Profiles of serological markers of HBV-infection in acute hepatitis B].

The authors demonstrate that severe and fulminant forms of acute hepatitis B (AHB) are associated with low concentrations of HBsAg and anti HBs in peripheral blood. In the majority of cyclic AHB cases HBeAg is registered in the serum for 2-3 weeks, whereas in more severe course of AHB its indication is shorter, with occasional occurrence of serological window. The more severe and longer was AHB course the lower was concentration of HBsAg in peripheral blood. The assessment of the complete profile of serological markers of HBV infection and HBsAg concentration in the serum in the course of the disease will promote more effective diagnosis of the disease pattern and outcome.

Acute Disease↗
PubMed1996

[Tropical malaria pattern in Russians living in the Republic of Guinea].

Tropical malaria in 188 Russians who have fallen ill in the Republic of Guinea was characterized by an acute onset, high irregular 6-day fever, intoxication, hepatosplenomegaly, moderate of severe forms, high incidence of recurrences. Combination of kinimax with fansidar seemed more effective than routine treatment with chlorochin.

Acute Disease↗
PubMed1995

[Acute cholecystitis as a problem of laparoscopic surgery].

The article deals with experience in 89 operations of laparoscopic cholecystectomy in patients with acute cholecystitis aged 17 to 82 years. A total of 92 attempts were made, 3 patients underwent laparotomy. Forty-five patients had catarrhal, 35 phlegmonous, and 9 gangrenous cholecystitis. In the preoperative period 37 patients were subjected to endoscopic retrograde pancreaticocholangiography, endoscopic papillosphincterotomy was performed in 28 of them, in 9 the operation was complemented by nasobiliary drainage. As a result intraoperative cholangiography had to be conducted only in 3 patients. Intraoperative complications developed in 42 and postoperative in 18 patients (local in 15 and general in 3). There were no fatal outcomes.

Acute Disease↗