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Biomedical subjects

A F Tsyb

Publications and source records attributed to A F Tsyb.

At least 19 recordsLinked to original sources
PubMed1992

[Contact radiotherapy of rheumatoid arthritis].

The authors have devised a method of contact radiotherapy with open radionuclides (198Au) to be used in the treatment of patients suffering from rheumatoid arthritis. Indications for therapy have been defined. In 360 patients suffering from rheumatoid arthritis, radioactive colloid gold was administered to the affected joints. The therapeutic effect was slow in development. The best clinical results were recorded at month 12. Considerable improvement was noticed in 70% of the patients, improvement in 20%, and in 10% of the patients, no therapeutic effect could be recorded. Good effect was ascertained in patients with X-ray Stage I and II disease (70%).

Adult↗
PubMed1991

[Intralymphatic administration of open radionuclides in complex treatment of rheumatoid arthritis].

A new method was developed for the treatment of patients with rheumatic arthritis using therapeutic effect of radioactive colloid aurum in the lower limb lymphatic vessels. Altogether 50 patients with various degrees of activity and stages of disease were treated. A positive therapeutic effect was observed in 84%. The method of endolymphatic radiotherapy with radioactive colloid aurum made it possible to give up cytostatic and glucocorticoid therapy and to reduce a dosage of nonsteroid antiinflammatory drugs.

Adult↗
PubMed1991

[Functional status of the pituitary-thyroid system in children and adolescents exposed to radiation as a result of the accident at the Chernobyl Nuclear Power Station].

The paper is concerned with the results of a follow-up over the period of 1986-1989 of function of the hypophyseo-thyroid system in children and adolescents (approximately 6000 persons), residing in the South-West of the Kaluga Region, where radiation fallouts were observed after the Chernobyl accident. The results were based upon the analysis of medical examinations and determination of the blood levels of TSH, T4 and T3. A certain functional activation of the thyroid system was observed in a majority of the examinees. A conclusion has been made of a necessity of a long-term follow-up of the thyroid of persons who received radioactive iodine in childhood.

Accidents↗
PubMed1991

[Transvaginal ultrasonography in the assessment of local extension of rectal cancer].

To explore potentialities of transvaginal sonography in the diagnosis of rectal tumors 33 female patients were examined. Transvaginal sonography was shown to be optimum for accurate local staging of rectal tumors. The overall staging accuracy for transvaginal sonography in this study was 94%. There were one understaged and one overstaged cases. Pathological pararectal lymph nodes were detected in 57.5% of the patients.

Adult↗
PubMed1990

[Around the Semipalatinsk proving grounds: the radioecological situation and the population radiation doses in Semipalatinsk Province (based on data from the report of the Interdepartmental Commission)].

The paper represents some results of a joint commission, organized by the USSR Ministry of Health by order of the USSR Council of Ministers at public requests. The commission worked in the area neighbouring the proving ground at Semipalatinsk in the period of May-July 1988. A radiological situation there was investigated after underground nuclear testing on July 8, 1989. The results of measurements and archive data were used to estimate doses of radiation exposure of the population in the period of 1949 (nuclear testing on the ground and in the atmosphere) and in the period of underground testing, It was shown that in the period of 1949-1963 approximately 10,000 people received increased doses of external and internal irradiation. A high level of radiation-induced chromosome aberrations was noted among them. The highest effective equivalent doses of external and internal irradiation were received by the residents in the villages of Folon' (1.6 Gy during the first testing in 1949), Karaul (0.37 Gy), Sarzhal (0.20 Gy), Semenovka (0.02 Gy). The annual effective equivalent doses at that period did not exceed 0.0056 Gy (the highest value) for the Semipalatinsk residents. Proceeding from the values of collective doses probable long-term effects (malignant tumors) were assessed. Recommendations and conclusions of the commission are presented.

Ecology↗
PubMed1990

[Ultrasonic examination and lymphography in the diagnosis of metastases of rectal cancer].

The diagnostic effectiveness of ultrasound and lymphographic investigations was assessed in 89 rectal cancer patients. Lymphography was shown to be a more informative method as it permitted the detection of metastases in 6 patients in whom USI results were negative, metastatic involvement in 2 patients, specifying the type of pathological changes of the enlarged lymph nodes in 14 patients. In a normal lymphographic picture metastatic involvement was detected in 37 cases using echography. More extended metastatic spreading was found on USI (as compared to lymphography) in one patient. The combined use of echography and lymphography improved the diagnosis of rectal cancer lymphogenous metastases.

Adult↗
PubMed1990

[Puncture biopsy with ultrasonic control in the diagnosis of space-occupying lesions of the organs of the abdominal cavity and lesser pelvis].

Fine-needle puncture aspiration biopsy was performed in 182 patients with various visceral tumors. The results were negative in 4 (2.2%) cases only. The malignant nature of tumor was established in 140 cases whereas benign--in 38. The histogenetic type of tumor was reliably established in 75% of patients. In 25% of cases, biopsy revealed a malignancy but failed to identify its origin.

Abdomen↗
PubMed1990

[Ultrasonic examination in secondary lymphedema of the lower extremities].

The article deals with the results of ultrasonic examination (USE) of 39 patients with secondary edema of the lower extremities. The authors developed a USE method which yields objective data characterizing changes of the structure, thickness, boundaries, and firmness of the soft tissues in lymphedema of the lower extremities of various severity. It was established that lymphostasis produced a characteristic ultrasonic pattern, which, as claimed by the author, may be used in differential diagnosis of lymphatic and venous edema of the extremities.

Adult↗
PubMed1989

[Contrast media: present status and future of their production and use].

Analysis of the problems involving the design and application of Soviet-made radiocontrast agents showed that the synthesis of such drugs as Iodamid, Triombrast, Etiotrast, Bilimin, and Bilignost in this country made it possible to eliminate the arrears in this field. Together with the elaboration of topics concerning the pharmacokinetics and adverse effects of the above contrast agents, this helped to create a sound scientific base for further work on the unsolved problems, primarily, (1) to synthesize Soviet non-ionogenic radiocontrast agents; (2) to prepare and introduce Soviet ultrasonographic contrast agents into practice; (3) to prepare and introduce magnetic resonance contrast ones into practice; and (4) to introduce unique radiocontrast agents such as triombrast as oil emulsion, oleoferrotrast, fine-dispersion barium sulphate, and chromoetiotrast into clinical practice and to set up their production.

Contrast Media↗
PubMed1988

Intra-arterial chemotherapy for advanced bladder cancer.

The results of prolonged intra-arterial chemotherapy in 61 patients with locally advanced bladder cancer (T3-T4) are discussed. Regional internal iliac artery infusion of chemotherapeutic agents was done daily for 5 or 7 days at a rate of 1 to 3 ml/h over an 18-20-h period. The total dosages of each course were 60-120 mg/m2 adriamycin, 2.5-3.5 g/m2 5-fluorouracil (5-FU), 20-40 mg/m2 methotrexate or 30-50 mg/m2 cisplatin. At 3 to 4 weeks after the completion of infusional chemotherapy the results were evaluated, based on data from control cystoscopy and sonography. One patient (1.6%) was free of tumor; an objective response of greater than 50% reduction in tumor size occurred in 26 (42.7%) patients; 34 (55.7%) demonstrated objective responses of less than 50%. No further increase in tumor size during the management was detected. Hematuria, dysuria and urine infection were controlled and pain was relieved. The use of cytostatics and prolonged iliac artery catheterization did not incur any serious complications.

Adult↗
PubMed1988

Transvaginal longitudinal ultrasonography in diagnosis of carcinoma of the urinary bladder.

In order to determine the staging of urinary bladder tumors accurately, it is very important to choose a suitable method of treatment and to reach the correct prognosis. In 1974, Watanabe and Holm performed the first transurethral and transrectal ultrasonography. They obtained sonograms of the involved bladder wall by radial scanning using a rotation transducer. The only weak point of this method is the difficulty of staging tumors in the apex, the neck, and the fundus of the bladder by transverse scanning. In 1982, Sekine et al repeated the results of testing a new transrectal transducer for electronic linear scanning in a urologic clinic. However, to our knowledge, no description of the transvaginal technique for routine vesical ultrasonography has appeared in the English-written literature. The purpose of this study is to visualize bladder tumors by longitudinal transvaginal scanning and to evaluate the new method for the staging of urinary bladder tumors.

Adult↗