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Biomedical subjects

A F Turner

Publications and source records attributed to A F Turner.

At least 19 recordsLinked to original sources
PubMed1992

Computed axial tomography on highly myopic eyes following scleral reinforcement surgery.

We performed computed tomography (CT) studies on six patients (with follow up ranging from 8 months to 18 years) following scleral reinforcement surgery, comparing the density of the observed implanted scleral material with both normal human sclera and myopic sclera. Results demonstrated the presence of a material on the posterior pole with a density greater than or equal to the experimentally determined density of ungrafted donor sclera. We conclude that CT is a useful method of evaluating both the position and long-term stability of implanted donor sclera.

Adult↗
PubMed1990

Preliminary report: imaging of Kaposi sarcoma and lymphoma in AIDS with indium-111-labelled liposomes.

Kaposi sarcoma and malignant lymphoma were successfully imaged with high purity liposomes containing indium-111 in two patients with AIDS. Gamma camera images of the patient with Kaposi sarcoma showed four discrete lesions along the left foot and calf with no foci along the right foot, and no uptake into clinically enlarged but non-neoplastic lymph nodes. The spread of the Kaposi sarcoma was proximal along the leg. The neoplastic cervical lymph nodes in the second patient who had large-cell diffuse intermediate grade lymphoma were also imaged successfully. Since Kaposi sarcoma and lymphoma frequently involve occult sites, liposome imaging may prove useful in the diagnosis and management of these diseases.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Successful imaging of human cancer with indium-111-labeled phospholipid vesicles.

Twenty-four patients with proven primary and/or metastatic cancer received single intravenous injections of phospholipid vesicles containing 0.5 mCi of Indium-111. Gamma camera scintigraphy 1 to 72 hours later visualized tumors in 22 patients (92%), including carcinomas of breast, lung, colon, prostate, kidney, cervix, thyroid, and soft tissue sarcoma, lymphoma, and melanoma. Tumor sites that were identified included soft tissues, bone, lung, liver, lymph node, and spinal cord. There were only two false-positive images in metastatic sites and four false-negative images in metastatic sites. Overall sensitivity for tumors in 97 individual sites was 85%, whereas specificity was 96%. Unsuspected areas of malignancy were seen in the lumbar subdural space, pleura, liver, thyroid, and lung. Besides tumor accumulations, homogeneous uptake was observed in normal liver and spleen. Radiation doses to these two organs were 2.2 and 2.9 cGy/0.5 mCi In-111, respectively. Whole body radiation dose was 0.3 cGy/0.5 mCi. The use of Indium-111-labeled vesicles permits a wide variety of human tumors in primary and metastatic sites to be imaged without toxicity and with radiation doses comparable to other radionuclide scanning techniques.

Humans↗
PubMed1988

In-111-labeled liposomes: dosimetry and tumor depiction.

Neutral phospholipid vesicles (liposomes) were loaded with 0.5 mCi (18.5 MBq) indium-111 and administered to 24 patients with various types of cancer. The median diameter of the liposomes was 77 nm, and lipid dose was 0.78-6.25 mg/kg. Scans obtained 24 and 48 hours after injection of In-111 liposomes showed gradual blood clearance with homogeneous uptake in the normal liver and spleen. Dosimetric estimates for these organs were 2.3 +/- 1.1 and 2.3 +/- 1.4 rad (.02 +/- .01 Gy), respectively, with a whole-body estimate of 0.28 rad (.003 Gy). Radiation dose did not correlate with lipid dose. Total renal excretion of In-111 was less than 2% of the injected dose in all but two patients. Transient eosinophilia occurred in two patients. Tumor was seen in the scans of 22 of 24 patients (unbinded readings). In-111-labeled liposomes may enable the demonstration of suspected or unsuspected sites of tumor.

Breast Neoplasms↗
PubMed1986

Iatrogenic pulmonary overpressure accident.

An unconscious victim of an overdose was intubated with an endotracheal tube to prevent aspiration. The respiratory therapist deflated the cuff of the endotracheal tube to allow for a retrograde oral air leak and then tightly attached the oxygen tube directly to the endotracheal tube. Seconds later there was a loud pop as the oxygen tube blew off the end of the endotracheal tube. The patient sustained both a hemodynamic and a neurologic decompensation as the result of marked pulmonary overinflation, with bilateral pneumothoraces and probable cerebral and coronary artery air emboli. We present the case in the hope that it will help avoid any such future occurrences.

Adult↗
PubMed1977

Phonoangiography by autocorrelation.

Phonoangiography, as a noninvasive quantitative analysis of arterial bruits, was conducted just prior to standard invasive radiographic angiography in 135 patients. Sound records from 162 carotid arteries were analyzed with a new processing technique employing a high speed analog acoustic analyzer, the autocorrelator. In 18 arteries with carotid stenosis, a correlation coefficient of 0.87 resulted between phonoangiographic diameter predictions and radiographic diameter estimates. Bruit analysis identified two patients with patent lumen diameters, but tortuous carotid vessels. One hundred thirty-three carotid arteries had no bruits that could be analyzed, but angiograms showed no extracranial stenosis. Four arteries from which bruits could not be analyzed were found to be totally occluded. Carotid phonoangiography appears applicable in approximately one of seven patients now requiring angiography of head and neck vessels. When applicable, phonoangiography is significantly correlated with angiographic findings.

Adult↗
PubMed1976

Lymphedema tarda.

The clinical recognition and evaluation of congenital lymphedema of the lower extremities with abrupt onset in a 51-year-old man are reviewed. A rational, systematic approach is outlined and exemplifies the use of an interdisciplinary effort to achieve accurate diagnosis through readily available diagnostic procedures.

Age Factors↗
PubMed1976

Diagnostic features of right ventricular myxoma.

The clinical diagnostic features of right ventricular myxoma are described in a recent patient and related to the 15 cases previously reported. The presence of a pulmonic systolic ejection murmur with a delayed (120 to 140 msec.) and accentuated pulmonic second sound, or calcification in the region of the right ventricular outflow tract should suggest this lesion. Cardiac catheterization with angiocardiography in diagnostic. Ga scanning may assist in the diagnosis and followup after surgical removal of the myxoma. Early surgical removal will avoid the possibility of sudden death.

Adult↗