Biomedical subjects

A F el Fakahany

Publications and source records attributed to A F el Fakahany.

4 recordsLinked to original sources

PubMed1997

Pairing of Schistosoma mansoni males in infected Syrian hamsters.

Pairing of male schistosomes in the liver of infected hamsters was recorded with Egyptians S. mansoni strain. The homospecific male pairs never carried each other in the gynaecophoric duct, but they being closed in either central or hepatic veins. Other perfused males and females en copula showed normal mating behaviour. The paired males were more or less in the same size. The random sexed miracidia used resulted in obtaining 1:2.1 female/male ratio. It is concluded that the random increase of male schistosomes may create the male pairing behaviour. Also, the migration of female against the blood stream to the mesenteric plexus of the host and the failure of male to catch them may lead to this homosexual pairing. The black haemozoin-like substance seen in mature females was also observed in the pairing males and this probably reflects the effect of scarcity or migration of females to the mesenteric plexus.

Animals↗

PubMed1994

Effect of praziquantel on sex hormone levels in murine schistosomiasis mansoni.

Changes in sex hormonal levels were studied in Schistosoma mansoni infected and praziquantel treated mice (400 x 2 mg/Kg), drug control and in normal control groups. It was observed that schistosomiasis lead to increase in the level of testosterone, progesterone and 17B-esteradiol, 60 and 70 days postinfection in male and female mice, respectively. In praziquantel treated group the level of testosterone was lowered 10, 20 & 30 days post treatment, progesterone and 17 beta-estradiol fell 30 days post treatment after primary rise. The mechanism of recorded changes will be discussed in details.

Animals↗

PubMed1994

Congenital toxoplasmosis among premature infants with different clinical pictures in Saudi Arabia.

No doubt, toxoplasmosis is a prevalent infection in all the Arab countries. However, the incidence differs from one country to another and even within the same country. Congenital toxoplasmosis is the most important form of the infection. In the present study, some 78 premature infants with different clinical pictures were examined for Toxoplasma IgG (by IHAT and ELISA) and Toxoplasma IgM (by ELISA). The results showed Toxoplasma IgG ranging between 32.1% (IHAT) and 46.2% (ELISA) while IgM (ELISA) was 23.1%. The highest positivity rate was among those suffering jaundice and the lowest was among those suffering fever of unknown origin. Protection of women particularly pregnant ones, from Toxoplasma infection is a must.

Animals↗

PubMed1993

Serum immunoglobulin and complement values in scabietic patients.

Immunity entails all the forces concerned with recognition, specific reaction and removal of foreign bodies after they again access into the body of the host. The immune system interacts with genetics and infectious agents as well as with metabolic, endocrine and environmental factors. The serum immunoglobulins (G.M.A. & E.) and complement (C3 and C4) were estimated in sixteen parasitologically proven patients with scabies. The causative agent was Sarcoptes scabiei. The results showed a high significant increase in the mean average of IgG., IgM. and in particular IgE pretreatment than in patients three months after treatment and in patients after treatment than in controls. On the other hand, there was a significant decrease in the mean average in the mean average of IgA after treatment was insignificant compared with controls. The C3 and C4 showed no significant changes in the mean average in the patients before or after treatment compared with controls. The changes in the IgG., IgM. and in particular IgE. may be specific reaction to the parasite or a non specific one to the dead parasite or its faeces or even to a secondary infection developed. On the other hand, the decrease in the IgA. may be due to the mite or its products which interfere with its synthesis. It is concluded that scabies is associated with a humoral immunological response against the mite infestation.

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