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Biomedical subjects

A F van Eeden

Publications and source records attributed to A F van Eeden.

7 recordsLinked to original sources
PubMed1987

The 'lung in shock' as a result of hypovolemic-traumatic shock in baboons.

The "lung in shock" syndrome is a constellation of early morphologic changes in the lung within 1 hour after polytrauma as indicated by human lung biopsies. A hypovolemic-traumatic (soft-tissue trauma together with bone fractures) baboon model with reinfusion was established to study these morphologic and associated pathophysiologic events. This model was developed in order to test the efficacy of therapeutic modalities in future studies. Nineteen baboons (eight sham, 11 shock) were anesthetized with spontaneous respiration while complete hemodynamic and blood gas monitoring was performed, along with light and electron microscopic studies of the lungs. Besides the usual shock-related hemodynamic disturbances and the metabolic acidosis, pathologic changes were found both on light and electron microscopy of the lungs but not on X-rays and measurements of blood oxygenation. In the shock group, morphologic evidence of endothelial and interstitial edema was associated with significant increases in lung weight. The fluid accumulation occurred in spite of careful control of pulmonary artery pressures during the study. More striking histologic findings were significant cellular infiltration of lung tissue, especially by leukocytes, showing evidence of degranulation. This baboon study, similar to studies undertaken in canines, shows that the hypovolemic (hemorrhagic) shock in association with trauma (fracture, soft-tissue trauma) causes ultrastructural morphologic changes that may precede potentially life-threatening functional changes in the lung.

Animals↗
PubMed1980

Shrapnel wound of the heart: a case report.

A case of cardiac injury in which a missile penetrated the inferior surface of the left ventricle and lodged in the interventricular septum is described. This unusual location, plus the fact that a piece of shrapnel at high velocity quickly loses speed owing to its aerodynamic instability, becoming a low-velocity missle, possible contributed to saving the patient's life.

Adult↗
PubMed1980

A clinical comparison between etomidate and methohexitone for anaesthetic induction.

A comparison study of the induction properties of the new propylene glycol formulation of etomidate (Hypnomidate) and methohexitone in 80 patients who underwent elective surgical procedures is reported. Both agents gave uniformly good inductions. Methohexitone induction was associated with an elevation in heart rate, but in the etomidate group no cardiovascular instability was seen. In both groups there was a 20-25% incidence of pain on injection, but this was almost exclusively confined to the patients who were injected through the dorsal vein of the hand rather than the antecubital vein. In only 1 patient in the etomidate group did slight involuntary movements occur, but 11 patients (28%) in the methohexitone group showed this side-effect.

Adolescent↗