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Biomedical subjects

A Féline

Publications and source records attributed to A Féline.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Tianeptine in episodes of major depression with melancholia and signs of endogenicity].

The effectiveness and good acceptability of tianeptine have been demonstrated in episodes of major depression without melancholia or signs of psychosis which are the valided indications of the tianeptine. In a way of research program, a multicenter study was conducted in 30 patients with D.S.M. III criteria for major depression with melancholia and signs of endogenicity as defined by the Newcastle scale. The patients were treated in a double-blind trial for 42 days. Administration of a placebo for 4 days prior to beginning the study was designed to eliminate rapid responders to placebo. The antidepressant effectiveness was evaluated on the Hamilton (HDRS), Montgomery and Asberg (MADRS) and global clinical impression (GCI) scales. The effect was satisfactory and statistically significant. Seventeen of the 30 patients (57 percent) included in this study improved with tianeptine (CGI-item 2). Results were comparable whatever the diagnosis established on DSM III criteria: bipolar depression, major depression, recurrent or isolated forms. The acceptability evaluated from patient complaints, measurement of blood pressure and laboratory tests was very satisfactory. Treatment was withdrawn in 14 patients with no subsequent withdrawal symptoms. These findings show that tianeptine can be prescribed with success for major depression episodes with melancholia (DSM III) and signs of endogenicity, although it cannot be concluded that patients should be given this treatment in first intention for this type of depression.

Adult↗
PubMed1990

[Formal thinking, logical-discursive operations and schizophrenia: experimental study of a clinical case].

This study, based on a single case experimental design, examined logical reasoning in a schizophrenic meeting the DSM-III criteria. The quantitative assessment carried out by 32 psychiatrists on a rating scale for logical thinking disorders (nine items, six points) of the retranscribed clinical interview showed 1. that the assessments varied in a statistically significant way according to items and psychiatrists, and that these variations were independent of their degree of experience--the correlations between the different items of the rating scale proved to be weak and not significantly different from zero; and 2. the study of the most contradictory statements carried out by a logician using reasoning analysis procedures concluded that there were in fact logical relationships between the subjects the schizophrenic talked about. The results are discussed in relation to the methodology of assessing formal thought in schizophrenia.

Adult↗
PubMed1978

[Symptomatology of inhibition].

This essentially descriptive paper deals with inhibition as a symptom or as a behavior pattern and studies the different areas of; inhibition of the intellect (i.e. a decrease in though production witnessed by disorders of language flow), reduced attention span (distractability, inability to concentrate), inhibition of volition (abulia, indecisiveness), memory inhibition (in the sense of selective amnesias, post-crisis amnesias, cyclical amnesias), restriction of the basic drives (which can touch the life principle, the need for sleep, hunger, sexual drive), emotional inhibition including a feeling of inferiority and self-doubt which affects interpersonal relations: in this sense inhibition can also manifest itself in experiences of estrangement and depersonalization. A dynamic study of inhibition should first deal with the presumed relationship between the symptom and a specific pathological process and analysis of the underlying inconscious mecanisms.

Affective Symptoms↗
PubMedDate not supplied

Identity disturbances and self-other differentiation in schizophrenics, borderlines, and normal controls.

The present study investigates identity disorders in schizophrenics and borderlines. Nineteen schizophrenics and 17 borderlines were compared with 18 normal controls. The technique used was an adapted version of the repertory grid test to describe the self and nine significant others (i.e., family members). Three indices were derived from the 10 person x 20 self-generated-attribute matrix to measure the extent to which self was differentiated from others: (1) overlap of salient attributes, (2) overlap of opposite attributes, and (3) degree of differentiation among others. Results showed that both schizophrenics and borderlines describe themselves more in terms of opposites than in terms of salient attributes. Differentiation among significant others was severely impaired in schizophrenics and preserved in borderlines. These findings were interpreted as a failure of the individuation process in schizophrenics and as an incomplete construal of self-identity in borderlines.

Adult↗