Biomedical subjects
Publications and source records attributed to A Farrow.
Vitamin B6 levels were determined in patients with idiopathic carpal tunnel syndrome. Results from this limited study strongly suggest that vitamin B6 deficiency may accompany carpal tunnel syndrome. This study did not address the question of the causal relationship between vitamin B6 status and development of symptoms.
This paper describes a case-control study of the occupational and environmental exposures of patients with myelodysplasia. The methodology, first described in Canada for solid tumors, estimates lifetime exposures to a number of potential toxic hazards or carcinogens. This pilot study confirms that the methodology, with the use of questionnaires and interviews, can estimate exposures to specific chemicals and shows some significant associations with myelodysplasia, including exposure to petrol or diesel compounds.
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In this cross-sectional postal study, the authors measured nitrogen dioxide levels inside infants' bedrooms and outside their homes. During the 2-wk monitoring period, the authors investigated the association between nitrogen dioxide levels and 20 infant symptoms. The subjects were 1,200 women who had infants aged 3-12 mo. Median levels of indoor and outdoor nitrogen dioxide were 6.8 and 12.6 ppb, respectively. Environmental factors that were associated significantly with indoor levels were gas cooking, cigarette smoking, reported traffic levels, and presence of a kerosene heater; use of a cooker hood was associated negatively with indoor nitrogen dioxide levels. There was no evidence for any short-term significant association between prevalence of respiratory symptoms and nitrogen dioxide levels. Diarrhea, the only symptom associated significantly and positively with indoor nitrogen dioxide levels, had unadjusted and adjusted odds ratios of 1.48 (95% confidence interval: 1.13, 1.95) and 1.38 (1.11, 1.70), respectively. This association is discussed in terms of a proposed mechanism with nitric oxide. No association between a gas cooker in the home and diarrhea was found. The association between diarrhea and nitrogen dioxide level might have been a chance finding; the authors investigated 20 symptoms, and at least 1 was expected to be significant at the .05 level. The finding, however, was similar to that reported in a previous study in which a gas cooker was a proxy for nitrogen dioxide exposure.