Serotonin and its metabolites: their respective roles in the production of hypothermia in the mouse.
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Biomedical subjects
Publications and source records attributed to A Feldstein.
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1. The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities.2. In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD(+) to a greater extent than by NADP(+).3. In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH.4. In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.
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The authors, reporting from Kaiser Permanente, describe a new program that may be helpful to other managed care providers in preventing workplace injury and minimizing disability after injury.