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Biomedical subjects

A Ferlito

Publications and source records attributed to A Ferlito.

At least 19 recordsLinked to original sources
PubMed1995

Laryngeal paraganglioma versus atypical carcinoid tumor.

Paraganglioma and atypical carcinoid tumor of the larynx are two neuroendocrine neoplasms that have often been confused in the past, and even in the present, in the literature. The clinicopathological profile of the two lesions is presented and the differential diagnosis is discussed. A correct diagnosis is of paramount importance, since treatment and prognosis depend on diagnostic accuracy and differ for the two lesions. Paraganglioma of the larynx is usually benign, whereas atypical carcinoid tumor is malignant and has an aggressive clinical course.

Adolescent↗
PubMed1995

Immunohistochemical markers in the diagnosis of neuroendocrine neoplasms of the head and neck.

Immunohistochemistry is important in the diagnosis of neuroendocrine neoplasms of the head and neck, particularly in the differential diagnosis of the various neuroendocrine neoplasms, although the results of staining should never be interpreted alone, but together with conventional histopathologic findings. It is emphasized that there are currently no markers capable of distinguishing between benign and malignant tumors. A correct diagnosis is of paramount importance, since treatment depends on the diagnostic accuracy and prognosis is naturally related substantially to the phenotype.

Adrenocorticotropic Hormone↗
PubMed1995

Malignant laryngeal tumors: phenotypic evaluation and clinical implications.

Malignant laryngeal tumors include a variety of oncotypes with differing biologic connotations, each calling for a different therapeutic approach and giving rise to a different prognosis. But the oncotype can only be accurately identified histologically by means of a technically adequate, representative biopsy specimen. Intrinsic malignancy varies with the structure of the neoplasm, so the choice of surgery, radiotherapy, chemotherapy, or laser therapy depends largely on tumor type. Most malignant laryngeal neoplasms are squamous cell carcinomas, but the rare cases of nonsquamous tumor include a wide array of oncotypes of which the true incidence is difficult to assess. Diagnosis is based on light microscopy, but may be supported by histochemical, immunocytochemical, and ultrastructural investigations that improve the accuracy of categorization of the specific tumor type. A precise histologic diagnosis, based on representative biopsy material, will lead to a better understanding of the tumor's likely behavior, and consequently to more effective treatment.

Humans↗
PubMed1995

Are clinical classifications for laryngeal cancer satisfactory?

All clinical classifications for laryngeal cancer are compromises based on clinical and imaging evaluations, with no concern for important elements such as phenotype, host-tumor relationship, and any concomitant nonneoplastic disease. The various staging systems are critically examined along with a report on the outcome of an international survey on the applicability of the TNM system in relation to laryngeal neoplasms, promoted by The Laryngeal Cancer Association.

Humans↗
PubMed1995

The natural history of early vocal cord cancer.

Pure "early cancer" is an intramucosal lesion, but does not include carcinoma in situ or dysplasia in which the malignant cells have not penetrated the basement membrane and therefore have no metastatic potential. The term is often erratically used to describe lesions with invasion of the muscle or cartilage structures and such a careless terminology adds confusion to the nomenclature for these neoplastic lesions. Malignant tumour development involves complex interactions between several factors, both environmental (or exogenous) and endogenous (i.e. genetic, hormonal, etc.). The natural history of neoplastic disease coincides with three chronologically distinct stages: initiation and promotion (the sub-clinical latency period), and progression (when the tumour usually becomes clinically visible). Early vocal cord cancer may be asymptomatic and more advanced than it seems. It has a high cure rate with various treatments: there is no treatment of choice for early cancer, but a choice of treatments. As it is obviously difficult, or even impossible, to control far-advanced laryngeal cancer, it is essential to concentrate efforts on study the initial steps in tumour development to facilitate early detection and timely therapy.

Carcinogens↗
PubMed1992

Non-occupational recurrent bilateral pneumoparotitis in an adolescent.

This is a case report of recurrent bilateral parotid swelling with intraglandular gaseous bubbles in a 14-year-old boy, together with a review of the literature on this condition, which is usually called pneumoparotitis. The disorder has been reported as an occupational hazard in wind instrument players and glass-blowers and also as a rare non-occupational disease, mainly in adolescents and often associated with psychological problems.

Adolescent↗
PubMed1992

Supraglottic versus glottic laryngeal cancer: epidemiological and pathological aspects.

Between 1979 and 1988, 432 cases of previously untreated laryngeal cancers were histologically diagnosed at the Institute of Pathological Anatomy of the University of Trieste. Of these cases, 192 were supraglottic and 182 glottic cancers. The overall crude incidence was 31.06 0/0000 in males and 2.29 0/0000 in females, with a male/female ratio of 10.2:1 for supraglottic cancers vs. 20.4:1 for glottic cancers. Our incidence values for laryngeal cancer, and supraglottic lesions in particular, are similar to those recorded in France, Spain and other areas of Italy, i.e. in nations where wine production and consumption is very high. The 3-year adjusted survival rate was 45.7% for supraglottic and 83% for glottic cancer patients. Subjects with supraglottic cancer often had a poor prognosis because of the high frequency of cervical lymph node involvement, recurrences and visceral metastases; cancers of the aryepiglottic folds presented the worst clinical evolution.

Adult↗
PubMed1992

[Long-term sedation with propofol in ICU: hemocoagulation problems].

The Authors have studied the effects of propofol on coagulation in 15 patients admitted to ICU. Propofol was used for long-term sedation (therapeutic range 3 mg/kg/h). Variables monitored included: platelets, PTT, PT, Fibrinogen, FDP, AT III. The effects on coagulation has been investigated in three groups of patients: group I) 5 patients that received propofol for 1-3 days; group II) 5 patients that received propofol for 4-10 days; group III) 5 patients that received propofol for 11-35 days. No difference were found about blood coagulation in this groups of patients before and after administration of propofol.

Adult↗
PubMed1991

Implantation of parotid pleomorphic adenoma in the upper neck.

This paper presents a case of pleomorphic adenoma from an abnormal site in the right upper neck in a patient surgically treated 4 years previously for pleomorphic adenoma of the right parotid gland. The lack of normal salivary tissue in the neck growth oriented us towards a diagnosis of implantation tumor, resulting from surgery of the parotid mass, rather than towards one of heterotopic tumor. The literature concerning salivary heterotopias and salivary tumors arising from heterotopic foci is also reviewed.

Adenoma, Pleomorphic↗
PubMed1991

Terminology and classification of neuroendocrine neoplasms of the larynx.

The authors discuss the terminology and classification of all neuroendocrine neoplasms of the larynx. After a review of the relevant literature, they suggest adopting the nomenclature recently recommended by the World Health Organization: carcinoid tumor, atypical carcinoid tumor, small cell neuroendocrine carcinoma and paraganglioma. This terminology is easy to apply, clinically meaningful and biologically sound. Carcinoid tumor, atypical carcinoid tumor and small cell neuroendocrine carcinoma are of epithelial origin whereas paraganglioma is of neural type. The authors emphasize that it is inadequate to make a diagnosis of 'neuroendocrine tumor or carcinoma', without its proper qualification.

Carcinoid Tumor↗
PubMed1991

Contribution of immunohistochemistry in the diagnosis of neuroendocrine neoplasms of the larynx.

This chapter illustrates the use of mono- and polyclonal antibodies as diagnostic tools for neuroendocrine neoplasms of the larynx on the basis of data from the literature and the authors' personal experience. It is suggested that a panel of antibodies should be adopted, rather than to rely on the specificity and sensitivity of a single marker. It is also emphasized that immunohistochemical methods should serve not as a substitute but as a useful adjuvant in evaluating the morphological criteria of these neoplasms.

Antibodies, Monoclonal↗
PubMed1991

Italian experience of voice restoration after laryngectomy with tracheoesophageal puncture.

This report concerns 102 cases of tracheoesophageal puncture performed as a means of secondary voice restoration after total laryngectomy, in 70 patients proving unable to learn esophageal speech and as a treatment of choice in a further 32 cases. Complications arose in 21 cases but were generally minor and could be overcome. Results were favorable in 45 of 70 and 29 of 32 cases, respectively. The method was considered effective, particularly when supported by the patient's determination to learn a verbal communication method.

Adult↗
PubMed1990

Neck dissection for laryngeal adenoid cystic carcinoma: is it indicated?

The authors report six cases of adenoid cystic carcinoma with a view to evaluating the validity of neck dissection in this tumor. Adenoid cystic carcinoma may invade regional lymph nodes by direct extension, but true embolic lymph node metastases are so rare, if they exist at all, that neck dissection may be considered an overtreatment.

Adult↗
PubMed1990

Laryngeal chondrosarcoma: incidence, pathology, biological behavior, and treatment.

Chondrosarcoma is the most common mesenchymal tumor of the larynx and approximately 200 cases have been collected in the world medical literature. It is less aggressive in the larynx than elsewhere: cervical or distant metastases are rare (8.5%), and although local recurrences are not uncommon, they are not catastrophic. A retrospective study was made on eight cases of laryngeal chondrosarcoma. Three cases had originally been diagnosed as idiopathic vocal cord paralysis, possibly because of early involvement of the cricoarytenoid joint or the distal portion of the recurrent nerve. This fact emphasizes the need for accurate laryngeal computed tomography in cases of vocal cord paralysis of unknown origin. Surgical excision is the treatment of choice for laryngeal chondrosarcoma, and conservative techniques may sometimes be appropriate. Supraglottic laryngectomy may be the technique of choice in the rare cases of epiglottic involvement.

Adult↗