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Biomedical subjects

A Ferrannini

Publications and source records attributed to A Ferrannini.

At least 55 records · Page 3Linked to original sources
PubMed1996

[Rokitamycin tolerance in patients with adverse reactions to chemotherapeutic agents].

The main task in the drug intolerance reactions is the choice of "alternative" drug by oral challenge. The tolerance of rokitamycine (RKM), a new macrolide with a wide activity spectrum in 133 antibiotic-intolerant patients has been studied by open oral challenge with incremental dosage until a cumulative dose of 406 mg. The RKM in 96.2% of cases has been well tolerated. Only 5 patients (3.8%) have had reactions, mainly "atypical" and of minor clinical importance, at cumulative doses ranging from 31.25 to 250 mg. The RKM has been well tolerated also by 6 patients who have had reactions to macrolides belonging to the same group (16 membered). Finally, the use of RKM as alternative drug in chemotherapeutics-intolerant patients has been proposed.

Administration, Oral↗
PubMed1990

[Inhibition by ketotifen of specific skin wheal reaction in atopic subjects].

In order to reconsider the ability of ketotifen (K) to inhibit the specific (allergen-induced) skin wheal reaction (SWR) and the correlated problems, 32 patients, all suffering from seasonal allergic rhinitis due to grass pollens, have been studied. K has been compared with sodium cromoglycate (SCG), which is not metabolized in man. SPT with grass pollen extracts before and after treatment have been performed in all patients, divided into two numerically equal groups treated with either drug at usual dosages for eight weeks. The specific SWR has been significantly inhibited by K, but not by SCG. The theoretical and practical meaning of this finding is discussed.

Adult↗
PubMed1983

Acute lymphoblastic leukemia hand-mirror cells. Study of nine cases.

Acute lymphoblastic leukemia with hand-mirror cells (HMC) was diagnosed in nine adult patients. Blast HMC were seen only in the bone marrow (12-57% range). Cytochemical studies revealed a positive reaction to tartrate-sensitive acid phosphatase in the tail portion of the cells in seven cases, with a strong, localized cytoplasmic reaction in four. Leukemic cells lacked surface immunoglobulins and were E rosette negative in all cases. Normal levels of adenosine deaminase activity (ADA) were found in five of the seven patients. Electron microscope studies confirmed the hand-mirror shape of the cell. These HMC contained large numbers of mitochondria and microspikes in the handle portion of the cell. The patients failed to respond to initial conventional ALL chemotherapy, but the prolonged survival with passable health of the majority of these, despite their lack of complete remission, is emphasized.

Acid Phosphatase↗
PubMedDate not supplied

[Changes in spirometric values induced by nasally administered beclomethasone dipropionate in patients with perennial allergic rhinitis].

Authors showed that it's possible to control the asthmatic component in patients with persistent allergical rhinitis without bronchodilatory drugs. AA. compared two groups of ten patients: Group A has been treated with antihystaminical drugs or ketotifen per os and Disodium chromoglycate per nasal spray, Group B has been treated with the same drugs and Beclomethasone Dipropionate per nasal spray more (400 mcg a day). Respiratory functionality tests (FEV1 and MEF75) have been carried out at the beginning and at the end of the trial and the subsequent clinical parameters have been considered: dispnoea attacks, rhinorrhaea, sneezes, lost working or school days. The results of the study showed after three months of therapy a statistically significant improvement of FEV1 and MEF75 in Group B only; moreover the patients of the Group B had lower number of asthmatic attacks then patients of the Group A.

Administration, Inhalation↗
PubMedDate not supplied

[Allergic respiratory pathology. Epidemiologic study on an atopic population from Southern Bari].

Three-hundred and thirty-three patients with respiratory allergic disease from southern Italy, a zone characterized by interesting environmental conditions, were studied from 1983-1986 in order to determine their salient epidemiological features. The classic allergological diagnostic procedures (history, skin Prick test and RAST) were utilized. Studies have confirmed the prevalence, in pre-puberty, of respiratory allergic disease in males and Dermatophagoides sensitization. The importance of olive pollen, which is the most common pollen sensitization in children with the tendency to be asthmogen is illustrated. Data concerning the distribution of sensitizations between rural and urban environments are discussed.

Adolescent↗