PubMed Health⌕ Search

Biomedical subjects

A Fertakis

Publications and source records attributed to A Fertakis.

At least 37 records · Page 2Linked to original sources
PubMed1985

C3 polymorphism in Greece.

The polymorphism of the third component of the human complement (C3) was investigated in a sample of 1,055 unrelated healthy individuals from nine different areas of Greece. The estimated gene frequencies were: C3S = 0.786 and C3F = 0.211. Three individuals were found to have rare variant C3 types. The allele frequencies resemble those reported for other Caucasian populations.

Alleles↗
PubMed1984

Plasma fibronectin (Fn) study in homozygous beta-thalassemia: relation to splenectomy and transfusion.

The concentration of plasma Fn was determined in non-splenectomized and splenectomized patients with homozygous beta-thalassemia, before and 7-10 days after blood transfusion. The mean Fn concentration of non-splenectomized patients before transfusion did not differ from that of matched normal controls but appeared significantly decreased following blood transfusion. On the other hand, in splenectomized thalassemics, Fn levels were increased but were unrelated to transfusion. It is concluded that Fn plays some homeostatic function when RES activity of thalassemic patients is altered either as a result of splenectomy or blood transfusion.

Adolescent↗
PubMed1984

Genetic markers in renal adenocarcinoma.

The distribution of phenotypes and gene frequencies of the 3rd component of complement (C3), group-specific component (Gc), haptoglobin (Hp) and transferrin (Tf) were studied in 50 patients with renal adenocarcinoma. The statistical analysis of our findings in comparison to the frequency of these genes in the general population does not reveal any correlation between the distribution of the Hp and Tf phenotypes and the disease. On the contrary, a statistically significant association was found between renal adenocarcinoma and C3F and Gc2 genes. The relative risk incidence of this malignancy is 2.07 and 1.94 respectively for the carriers of these genes. These data indicate that genetic factors, possibly related to the immune mechanisms and calcium metabolism, play a role in the pathogenesis of renal adenocarcinoma.

Adenocarcinoma↗
PubMed1984

C3 polymorphism in beta-thalassemia.

The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 beta-thalassemic patients and in 112 carriers of the beta-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous beta-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patients.

Adolescent↗
PubMed1984

Genetic markers in carcinoma of the prostate.

The distribution of phenotypes and gene frequencies of the third component of complement (C3), group-specific component (Gc), haptoglobin (Hp) and transferrin (Tf) were studied in 115 patients with carcinoma of the prostate. The statistical analysis of our findings in comparison to the frequency of these genes in a control group of 155 patients with benign prostatic hyperplasia does not reveal any correlation between the distribution of the Hp and Tf phenotypes and the disease. On the contrary, a statistically significant association was found between carcinoma of prostate and C3F and Gc2 genes. The relative risk incidence of this malignancy is 1.56 and 1.81, respectively, for the carriers of these genes suffering from benign prostate hyperplasia.

Complement C3↗
PubMed1983

[Genetic markers in benign hypertrophy of the prostate].

The distribution of phenotypes and gene frequencies of the C3 component of complement, group-specific component, transferrin and haptoglobin were studied in 155 patients with benign prostatic hyperplasia. A statistical analysis of the findings in comparison with the frequency of these genes in the general population failed to demonstrate any correlation between phenotype distribution and benign prostatic hyperplasia.

Complement C3↗
PubMed1983

A simultaneous study of the polymorphism of five proteins in the serum and the urine of nephrotic patients.

The phenotypes of the haptoglobin (Hp), ceruloplasmin (Cp), group-specific component (Gc), transferrin (Tf), and third component of complement (C3) were determined simultaneously in the serum and urine of patients with proteinuria secondary to nephrotic syndrome of various types. In a large number of cases the patterns of Hp, Cp, and C3 phenotypes in the urine showed marked deviations from those in the corresponding serum either in the mobility or the number of their electrophoretic bands. The monomeric Hp and the Cp were found to have a very augmented urine/serum ration in some cases. Such differences were not detected in the electrophoretic appearance of the Gc and Tf phenotypes. Our results imply that in the proteinuria of the nephrotic syndrome, factors other than molecular weight interfere in the passage of proteins through the glomerular wall.

Adolescent↗
PubMed1983

HBeAg/anti-HBe antigenic system in liver diseases in Greece.

HBeAg and anti-HBe were sought by RIA in the serum of 320 HBsAg-positive and 27 HBsAg-negative Greek patients with acute and chronic liver diseases. The incidence of HBeAg and anti-HBe in the group of 60 patients with acute hepatitis B was 23% and 77%, respectively. Among the 35 patients with chronic active hepatitis 6 (17%) were HBeAg-positive and 24 (69%) anti-HBe positive; among the 25 patients with chronic persistent hepatitis 3 (12%) were HBeAg-positive and 22 (88%) anti-HBe positive. Similar results were found in the groups of patients with cirrhosis and hepatoma. These findings show that all cases of acute hepatitis B were HBeAg-positive at the onset of the disease and a seroconversion to anti-HBe appeared very early in most of the cases. The extremely high incidence in particular of anti-HBe in the Greek patients with chronic liver diseases is in disagreement with the results of other studies from other populations. These differences may express differences in the immune response of the host in the different populations, or in the nature of the infecting strain commonly present in each country. Most of the HBsAg-negative patients with cirrhosis were found to be HBeAg or anti-HBe-positive.

Carcinoma, Hepatocellular↗
PubMed1983

[Genetic markers in papillary cancer of the bladder].

The distribution of the phenotypes and the gene frequency of the 3rd fraction of complement (C3), the specific group (Gc), haptoglobin (Hp) and transferrin were studied in 133 patients with transitional cell cancer of the bladder (papillary cancer). Statistical analysis of these results, in comparison with the frequency of these genes in the general population, was unable to demonstrate a correlation between the distribution of these phenotypes and papillary cancer.

Carcinoma, Papillary↗
PubMed1982

[Estimation of serum beta 2 microglobulin in carcinoma of the bladder (author's transl)].

beta 2 Microglobulin is a low molecular weight protein synthesised by lymphocytes and neoplastic cells. The authors measured levels of this substance in the plasma of 40 patients with carcinoma of the bladder and normal renal function. 26 subjects were used as controls. Plasma levels were markedly higher in the bladder carcinoma sufferers than in the normal controls. Levels were also higher in invasive carcinomas than in superficial lesions. beta 2 microglobulin may therefore not be considered to be a specific indicator of carcinoma of the bladder but rather as a factor offering the possibility of measurement of the secretory activity of tumour cells.

Adult↗
PubMed1977

Serum levels and alpha1-antitrypsin phenotypes in active pulmonary tuberculosis.

alpha1-at phenotypes and serum levels were studied in 100 Greek patients of pulmonary TBC by starch-gel electrophoresis and radial immunodiffusion. The mean value of alpha1-at (315 +/- 77) was significantly lower (p less than 0.005) than in the control group. An attempt is made to explain this finding based on the alpha1-at phenotypes distribution in the TBC patients.

Female↗