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Biomedical subjects

A Filippi

Publications and source records attributed to A Filippi.

At least 37 records · Page 2Linked to original sources
PubMed2000

A retrospective classification of tooth injuries using a new scoring system.

The WHO classification presently in use categories dental trauma only according to the main injury. A new scoring system will now enable more precise and complete diagnosis of tooth injuries. In an initial retrospective investigation, 100 traumatised teeth were classified according to the WHO and the new scoring systems. Clinical and radiological examinations and another evaluations using the new scoring system were made at the time of follow-up examination. Avulsion, intrusion, and root fractures (score < 30) showed the most unfavourable findings at the time of the accident. In comparison, the most favourable findings were shown by concussion and first degree crown fracture (score > 70). A comparison to the WHO classification occasionally revealed noticeable score variations within a single WHO type of injury. Generally, a strong interdependence was observed between the evaluations at the time of the accident and at the time of the follow-up examination (P < 0.001). If the score at the time of the accident was equal to or larger than 57, a successful therapy was usually ensured (P < 0.001). The new scoring system enables more complete diagnosis as well as permitting statements to be made concerning prognosis.

Chi-Square Distribution↗
PubMed2000

Periodontal healing after intentional auto-alloplastic reimplantation of injured immature upper front teeth.

BACKGROUND/AIMS: Conventional endodontic treatment results in high complication quota when performed in immature teeth. Intentional reimplantation with extraoral insertion of an endodontic implant (auto-alloplastic reimplantation) is an alternative. METHOD: In a retrospective study, the healing of 40 teeth reimplanted intentionally according to this method in patients aged 7 to 15 years was evaluated. Clinical tests (palpation, percussion sound, periotest values) and radiographical examinations were used to determine the type of periodontal healing (inflammatory resorption/periodontitis apicalis; replacement resorption/ankylosis; normal healing). RESULTS: Mean lifetime of the replanted teeth was 59.2+/-42.5 months, estimated survival time on the basis of the Kaplan-Meier analysis was 99.5 months. 17 teeth (42.5%) were classified as failures, mostly due to inflammatory resorption or periodontitis apicalis. Further investigations demonstrated that success rate and retention period of intentionally replanted teeth depend on the preoperative condition of the pulp. Teeth with preoperative infection suffered frequently from inflammatory resorption or periodontitis apicalis after being replanted (14 of 28 teeth). Estimated survival time according to Kaplan-Meier was 75.5 months. In contrast, inflammations or progressive resorptions were not observed in teeth without preoperative infection of the pulp. All these 12 teeth showed normal periodontal healing and regular tooth mobility. In the absence of any pathology in clinical or radiological findings after an average functional period of 72.3 months, the prognosis can be presumed excellent. Estimated survival time of 148.3 months according to Kaplan-Meier differs significantly from survival time of teeth infected preoperatively. CONCLUSIONS: From the results of this investigation, it may be concluded that an infection of the pulp - due to delay of treatment or attempts at endodontic therapy - should be avoided before intentional replantation of immature front teeth with pulp necrosis. Periodontal healing of the autologous root is not impaired by the insertion of posts made of Al2O3-ceramics or titanium. The inserted posts do not ankylose. Orthodontic movement of auto-alloplastically replanted teeth is possible.

Adolescent↗
PubMed2000

Detected atrial fibrillation in north Italy: rates, calculated stroke risk and proportion of patients receiving thrombo-prophylaxis.

BACKGROUND: Atrial fibrillation (AF) is a major risk factor in the development of ischaemic stroke. The rate of embolic events can be reduced significantly by appropriate therapy. Epidemiological data and information about the attitude of physicians towards prophylaxis of thromboembolism are crucial to determine future strategies to decrease strokes in patients with AF. Unfortunately, these data are unknown in Italy. OBJECTIVES: The aims of this study were to study the prevalence of diagnosed AF in northern Italy, to estimate the percentage of high, moderate and low risk patients and to investigate the pattern of embolic prophylaxis among GPs. METHODS: Fifty-one GPs reviewed all the clinical records of subjects aged >/=40 years and identified those patients with chronic or paroxysmal AF. RESULTS: Among 41 050 patients, 719 [1.75%; 95% confidence interval (CI) 1.59-1.91] had AF (70% chronic, 30% paroxysmal). Only 4% were at low risk for ischaemic stroke, whereas 32% were at moderate and 64% at high risk. Contraindications to antiplatelet or anticoagulant therapy were present in 11% of AF patients. Antithrombotic prophylaxis was underused among the 51 GPs. CONCLUSIONS: Detection of AF could be 30-40% lower than real prevalence and, therefore, adequate evaluation and treatment aimed at avoiding ischaemic stroke could be denied to a great number of Italian patients. AF detection and prophylaxis of thromboembolic risk can be improved among GPs in northern Italy.

Aged↗
PubMed1999

[Cytokeratin and p53 expression of odontogenic cysts].

The histopathologic diagnosis of odontogenic cysts is based mainly on the morphological nature of the epithelial lining of cysts and their origin. We used the international histologic classification set up by the World Health Organisation in 1992. The aim of this study was to investigate the differentiation of various types of cyst using an immunohistochemical technique rather than by conventional morphological assessment. A standard immunocytochemical method (APAAP method), applying anticytokeratin monoclonal antibodies and a p53 antibody, was used for the diagnosis of odontogenic cysts. A total of 57 jaw cysts were diagnosed according to clinical, radiological and pathological criteria as radicular cysts (20), dentigerous cysts (20) and keratocysts (17). The results proved that cyst type can be distinguished by the pattern of staining using the monoclonal antibodies CK7, CK19, CK20 for cytokeratins and the clone DO-7 for the p53 protein. Staining with the monoclonal antibodies CK7 and CK20 did not distinguish type. CK19 was not detected in keratocysts and p53 was only expressed in keratocysts. This may prove to be diagnostically useful for the more precise distinction between different cyst types.

Epithelium↗
PubMed1999

Sensory disorders after separation of the nasopalatine nerve during removal of palatal displaced canines: prospective investigation.

During a prospective study after separation of the nasopalatine nerve at the foramen incisivum during exposure or removal of impacted and palatal displaced maxillary canines, 59 patients were examined neurologically for 4 weeks postoperatively over an investigation period of 18 months. During the first week after the operation, subjective as well as objective sensory disorders were found in all of the patients, but after 4 weeks at the most no neurological deficit could be detected in any patient.

Adolescent↗
PubMed1999

Investigations on a cell culture medium for storage and transportation of avulsed teeth.

Non-physiologic storage of avulsed teeth leads to a high incidence of root resorption, resulting in poor prognosis. This study investigated the suitability of specially composed cell culture media for storage of extracted teeth for up to 48 hours. Autoradiographic investigations revealed that the proliferative activity of periodontal ligament (PDL) cells of teeth stored in cell culture medium for up to 48 hours increased with storage time. Studies on proliferation of PDL cells after storage of teeth in different media for up to 24 hours demonstrated that the proliferative activity is dependent on the composition of the medium. Immunohistochemical investigations with markers for cell proliferation revealed that pulp cells of extracted immature teeth show numerous proliferations after storage for up to 24 hours in a special cell culture medium but few proliferations after storage in Hanks Balanced Salt Solution (HBSS). The investigations indicate that a special cell culture medium can preserve cell viability of PDL cells adhering to extracted teeth for at least 48 hours. The in vitro results are confirmed by a case presented: After storage of two upper central incisors for 36 hours in the cell culture medium the teeth could be successfully reimplanted after extraoral insertion of titanium posts into the root canal (auto-alloplastic reimplantation). Clinical and radiological follow-up examinations for 12 months revealed normal periodontal healing.

Autoradiography↗
PubMed1998

[Extrafollicular variant of centrally located adenomatoid odontogenic tumor].

An adenomatoid odontogenic tumor has been reported which was not connected with any impacted or displaced tooth. The clinical and radiographical results were consistent with a non-odontogenic cyst, but in this case the pathohistological examination revealed string-like and partly cross-linked cells of odontogenic epithelium as well as solid aggregates of epithelia, possessing gland-like structures at their centers. Furthermore, small deposits of PAS-positive materials could be seen which could be interpreted as non-mineralized dentine with a tubular basic structure. The therapy consisted of completely enucleating the tumor. Any recurrence of malignant degeneration has not yet been reported.

Adult↗
PubMed1998

Transplantation of displaced and dilacerated anterior teeth.

The therapy of dilacerated permanent anterior teeth usually involves surgically removing the tooth. Subsequently, orthodontic methods for closing the space or keeping it open are preferred until the patient reaches an age when definitive implantological or prosthetic treatments may be used. Anterior tooth transplantation should be considered as an alternative to surgically extracting the tooth. This study describes a period of investigation covering 3 years during which neither replacement resorption nor inflammatory resorption was diagnosed in the five transplanted teeth. The clinical tooth mobility was similar to that of the adjacent teeth. In spite of the vertical loss of bone shown radiographically no pathologically enlarged pockets or recessions have been found. It is not yet possible to make any comments on the prognosis for the long term.

Apicoectomy↗
PubMed1997

Sequestration of the alveolar bone by invasive aspergillosis in acute myeloid leukemia.

Compared to non-invasive aspergillosis, invasive aspergillosis in the region of the mouth, jaw and face has rarely been reported. It occurs particularly often in the presence of haematological oncological illness. The case of a patient suffering from acute myeloid leukemia is described; he contracted invasive aspergillosis of the lungs and the alveolar processes in the course of chemotherapeutic treatment. All the alveolar processes in the region of the premolars and molars were demarcated and had to be removed by sequestrectomy. The therapy of invasive aspergillosis should be carried out within the framework of intensive interdisciplinary treatment. In addition to systemic and local antimycotic therapy, the debridement of necrotic hard and soft tissue was necessary.

Acute Disease↗
PubMed1996

Dental treatment of handicapped patients using endotracheal anesthesia.

Dental treatment using endotracheal anesthesia is indicated where acute odontogenic infections, accidental injuries, or multiple caries and periodontitis marginalis require surgical and/or restorative treatment. It is also indicated where it is not possible to use psychological support during local anesthesia or during premedication or analgosedation. Dental treatment of handicapped patients using endotracheal anesthesia is described, along with indication and frequency of such treatment. The state of the dentition is illustrated, along with its relationship to the oral hygiene the handicapped patients receive. The main points of the intraoperative dental procedures and the follow-up of patient care are reported. Postoperative dental or general medical complications have not occurred within the patient population under study.

Adolescent↗