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Biomedical subjects

A Fioretti

Publications and source records attributed to A Fioretti.

33 records · Page 2Linked to original sources
PubMed1980

["Vacuum petrosum" in the pneumatized petrous portion of temporal bone and associated disturbances of cranial nerve functions (author's transl)].

Authors observed in cases of kryptogenetic diseases of cranial nerves V, VII and VIII a significant higher frequency of well pneumatized petrous portion of the temporal bone than in normal population. They suppose that, parallel to the symptoms of Eustachian tube occlusion in the middle ear region, the "Vacuum Petrosum" causes these disturbances of cranial nerve functions and try to interpret the mechanism in the particular cases.

Cranial Nerve Diseases↗
PubMed1976

Autoantibodies and spleen cell-mediated cytotoxicity in adriamycin-induced myocardiopathy in rabbits.

Spleen cells from rabbits affected by adriamycin-induced cardiomyopathy were specifically cytotoxic for rabbit embryonic heart cells in microcytotoxicity tests. The interactions between "sensitized" spleen cells and rabbit embryonic heart cells were observed by scanning electron microscopy. Sera from these rabbits were shown by immunofluoresence to contain antibodies reactive with rabbit embryonic heart, kidney, and muscle cells. Cytotoxic antibodies were not detected. These sera contained factors that enhanced the cytotoxicity mediated by "sensitized" spleen cells and made normal spleen cells capable of destroying targets. The detection of these factors and of cytotoxins was dependent on the method of target-effector cells treatment by serum.

Animals↗
PubMed1975

Antiviral activity of a pyrazino-pyrazine derivative.

The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia viruses. It had no effect on ECHO 9 virus. Therapeutic trials showed activity also on herpetic keratoconjunctivitis experimentally induced in rabbits.

Adenoviruses, Canine↗
PubMed1975

A case of pneumonia associated with cytomegalovirus (CMV) and anti- CMV antibody detection.

A case of pneumonia associated with acute CMV infection is reported. A 34 year-old man was admitted with fever (39 degrees C equals 102.2 degrees F), malaise and dyspnea. Clinical findings were characteristic of viral pneumonia. Crepitant rales to chest auscultation were heard all over the lung. X-ray picture showed evidence of interstitial pneumonia. Leucocyte counts were normal whilst lymphocyte counts elevated. Bone marrow examination showed an increase of lymphocytes and lymphoblasts. To palpation liver and spleen were slightly enlarged. Liver function tests were slightly abnormal. Bacteriological tests on urine and blood and Paul-Bunnel test were negative. Antibiotic therapy was ineffective. CMV was isolated from saliva and urine. Serological studies (elevated CF and precipitin antibody titer) suggested the diagnosis of a CMV infection. The patient recovered in 3 weeks.

Adult↗
PubMed1973

Growth characteristics of cytomegalovirus in human fibroblasts with demonstration of protein synthesis early in viral replication.

In high-multiplicity infection of human fibroblasts, human cytomegalovirus of WI-38 human diploid cells produced early cell rounding 6 to 24 h after inoculation. This early cell rounding was caused only by inoculation with infectious virions. Inhibitors of protein synthesis, but not DNA inhibitors, prevented this cytopathic effect. Apparently, a new protein is synthesized in infected fibroblasts from about 2 h postinoculation. Infectivity of cell-associated and supernatant infectious virus reached maximal levels at 5 to 7 and 10 days postinoculation, respectively. Synthesis of DNA, infectious virus, complement-fixing antigen, and precipitin antigen all began between 24 and 48 h, with the bulk of synthesis occurring 48 to 96 h postinoculation.

Amino Acids↗
PubMed1973

Nonproductive infection of guinea pig cells with human cytomegalovirus.

Human cytomegalovirus was capable of adsorbing to and penetrating guinea pig cells, but was unable to replicate new virus. Cultures infected with virus inoculum of high titer showed a cytopathic effect (CPE) characterized by cell rounding. This CPE depended upon the presence of infectious virus, and its extent was directly related to the multiplicity of infection. Staining by indirect immunofluorescence by using human convalescent sera was positive as early as 4 h postinfection. Maximal fluorescence was observed 24 h postinfection when 50% of the cells contained fluorescent antigens both in nuclei and cytoplasm. No evidence for viral replication was found, and no defective particles were detected by electron microscopy. Treatment with actinomycin D or with cycloheximide strongly inhibited both the fluorescent antigens and the CPE, whereas 5-fluorodeoxyuridine and bromodeoxyuridine were ineffective.

Animals↗