Potential risk for dengue hemorrhagic fever: the isolation of serotype dengue-3 in Mexico.
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Biomedical subjects
Publications and source records attributed to A Flisser.
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Methods for the quantitation of seric immunoglobulins are compared in this work: euglobulins by the Sia methods vs. IgM by radial immunodiffusion, and gammaglobulins with the zinc reactive vs. IgG by radial immunodiffusion. The results of the analysis of 81 sera of patients from the National Institute of Cardiology indicates that the values obtained with the methods for euglobulins and gammaglobulins are comparable to those obtained for IgM and IgG by radial immunodifussion.
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Quantification of CD4+ T lymphocytes and viral RNA in patients with HIV/AIDS. Levels of progression markers (viral load and CD4+ T lymphocytes) in 410 patients with HIV/AIDS that were in different clinical stages of the disease and under different therapeutic schemes were quantified. The objective was to determine the correlation between values of progression markers and clinical stage of the patients. Commercial methodologies for the quantification of lymphocytes, subpopulations and circulating viral RNA were used. Results indicate that there was a correlation between low CD4+ values and high viral load in patients with antiretroviral treatment but not in patients without treatment. Furthermore, analysis of 1,208 samples processed during 1999 showed that 46% of the patients had less than 200 CD4+ T lymphocytes/mL blood and more than 500 copies of circulating viral RNA. Implications of these results in public health in Mexico are discussed.
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An analysis of immunodiagnostic data for human cysticercosis by ELISA in 1,052 cerebrospinal fluid (CSF) and serum samples obtained directly from patients or their physicians from different hospitals during 1989-1991, as a result of the diagnostic support service that has been offered to the medical community since 1976, was performed. Overall positivity was 18 per cent. This value was slightly lower when only CSF was analysed (14%) and lowest in the case of serum samples (4%). Analysis of the CSF positivity in ELISA with respect to imaging findings yielded a predictive value of 93 per cent while in cases of excision of cysticerci by neurosurgery 67 per cent sensitivity was obtained. The high positive predictive value, the specificity and the sensitivity of ELISA indicate that this assay is useful to confirm the imaging diagnosis of neurocysticercosis when CSF is used or it can be used as a diagnostic alternative when imaging studies are not available.
There have been 2521 articles published on cysticercosis between 1965 and 1995. An analysis of these articles is presented in this paper and includes the subjects, grouped in 61 descriptors and the frequency of each one, the number of articles published each year, which has increased, the journals used, in total 663, 7% of which include 42% of the articles, the parameters used to measure the quality and importance of the main journals used for cysticercosis, for example, 56% have impact factor, the authors and co-authors which add 4848, of these, 59 have published between 9 and 79 articles each one, the analysis of their frequency of publication indicates that once they start publishing on cysticercosis they follow on in this area. Of the most productive authors 58% are Latinoamerican, 22 of which are Mexican.
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