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Biomedical subjects

A Focà

Publications and source records attributed to A Focà.

54 records · Page 3Linked to original sources
PubMed1980

[In vivo and in vitro activity of Streptococcus faecium extract on Herpes simplex virus].

The effects of substance or substance extracted from Str. faecium SF 68 on HSV-1 are evaluated. The "in vivo" assay show that bacterial extract introduced i.p. in mice simultaneously with HSV-1 brought about 100% of survival, but bacterial extract after virus challenge brought about complete mortality of mice. "In vitro" assays show that bacterial extract reduce significantly PFU number. It seemed that Str. faecium extract affected the virus at the stage of adsorption on the host cells.

Animals↗
PubMed1980

"In vivo" and "in vitro" effects of a bacterial extract on Herpes Simplex Virus.

The present studies were designed to evaluate the effects of substance or substances extracted from Escherichia coli on Herpes Simplex Virus. The "in vivo" assays show that bacterial extract introduced i.p. in mice simultaneously with HSV2 brought about 100% of survival, but the inoculation of crude extract after virus challenge brought about complete mortality of mice. "In vitro" assays show that the crude extract reduced significantly the numbers of PFU; better results were obtained when the crude extract was inoculated before the virus inoculation.

Animals↗
PubMed1979

[Determination of umbilical cord blood Ig and its correlation with prenatal infections (author's transl)].

IgG, IgM and IgA were measured in 120 funicular blood samples. At the same time, these determinations were assayed in the mothers. In the serum samples of the newborn, IgA and IgM were found to have levels over 20 mg/100 ml. Antibodies against rubella virus, cytomegalus virus, Listeria monocytogenes and Toxoplasma gondii were measured in order to investigate a possible intrauterine infection. All Ig determinations were performed through the radial immunodiffusion method.

Adult↗
PubMed1979

[Determination of alpha-1-fetoprotein during pregnancy].

218 samples of serum of pregnant women from 144 normal and 12 risky pregnancy, are tested for AFP RIA, radial immunodiffusion and slide agglutination. The results, according to thet of other AA., as regards un normal pregnancy AFP behaviour, emphasize the necssity to have more data from the same subjects during pregnancy, in order to plot a significant curve for the interpretation of the single values. As regards the technique, the delicacy and the specificity of the research, suggest the use of very sensible methods, which leave simplicity of execution and immediacy of results, out of consideration.

Adult↗
PubMedDate not supplied

Different effects of bacterial lipopolysaccharide on superoxide anion production by macrophages from normal and tumor-bearing rats.

Bacterial endotoxins or lipopolysaccharides (LPS) exhibit a wide range of modulatory activities on immunocompetent cells. Among the numerous effects of LPS on macrophages, an enhancement of superoxide anion (O2-) release has been reported. In previous studies carried out on tumor-bearing rats, it was found that several functions of peritoneal macrophages such as phagocytic, microbicidal and antiviral activities were depressed. In this paper we evaluated the spontaneous or phorbol myristate acetate (PMA)-induced production of superoxide anion by macrophages from tumor-bearing rats with respect to controls. Moreover, the effect of in vitro priming with LPS on O2- production by the same cells was studied. It was found that the pattern of superoxide release by macrophages from tumor-bearing rats is significantly different from controls. Preincubation of macrophages from normal rats with LPS enhanced the spontaneous and PMA-induced production of O2-. In contrast, the same concentrations of LPS did not prime macrophages from tumor-bearing rats.

Animals↗
PubMedDate not supplied

Adherence of Staphylococcus strains to human urinary and buccal epithelial cells.

91 strains of Staphylococci belonging to different species were investigated for their adhesive capacity to urinary and buccal human epithelial cells. Furthermore the adherence of the same bacterial strains was evaluated in relation with their methicillin-sensitive and methicillin-resistant properties. S. aureus showed an high adhesion to buccal and urinary cells; S. saprophyticus and S. epidermidis attached mainly to uroepithelial cells and to buccal cells, respectively. Bacterial strains, either sensitive or resistant to methicillin antibiotic, did not exhibit significant differences of adhesive capacity.

Adhesiveness↗
PubMedDate not supplied

[Prospects in the field of the antipolio vaccination (author's transl)].

Poliovirus vaccines (Salk-type and Sabin-type) have virtually eliminated paralytic poliomyelitis. Important subjects of study are the back-mutation of the type 3 degrees, the effect of the Sabin vaccine in addition to Salk vaccine, the development of vaccines to virus substructures and the synthetic-vaccines.

Poliomyelitis↗