Biomedical subjects
Publications and source records attributed to A Forget.
Antisera to chicken brain, thymus and bursa of Fabricius were prepared in rabbits and rendered organ-specific by appropriate absorptions. Brain was shown by immunofluorescence and immune adherence to have common antigenicity with the bursa of Fabricius but not with the thymus.
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Homologous anti-staphylococcal sera passively potentiated the development of experimental staphylococcal synovitis infection of chickens. These antisera obtained from chickens hyperimmunized with live Staphylococcus aureus were selected according to their immune adherence and agglutinating properties. While the agglutinins rose steadily for 11 weeks during the hyperimmunization schedule, the immune adherence antibody titers reached a peak at 8 weeks and dropped to almost zero 2 to 4 weeks later. The enhancement activity of these antisera was associated with a relatively high level of immune adherence antibodies and seemed not to be correlated with their agglutinin titers.
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Explore the source record for details and available documents.
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The correlation analysis which has already proved its value in ecology has not yet been applied to the determination of virulence indicators. Its application to a group of Clostridium perfringens type A strains has brought out some characters that may be considered as virulence indicators. This study suggests that the toxicity of the culture supernatant fluids for mice is significantly correlated with the virulence for mice and guinea pigs. A significant correlation was found between the virulence of the fluid cultures for mice or guinea pigs and the coagulation of milk, production of gas (in deep agar), hydrogen sulfide production, and fermentation of glucose, sucrose, maltose, and levulose.
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To demonstrate that an enhancement phenomenon might be involved during the development of bacterial infections, one has to establish that specific humoral antibodies protect, in some way, microorganisms against the defence reations of the host. This report presents the evidence that specific antibodies could be evolved in assuming a certain survival of bacterial cells in host's tissue. (1) Homologues antistaphylococcal sera passively potentiated the development of experimental staphylococcal synovitis infection of chickens. The enhancement activity of the antisera was associated with a relatively high level of immune adherence antibodies and seemed not be correlated with their agglutinin titers. (2) The passive transfer of chicken anti-Brucella immune globulins promote the survival of B. abortus in the spleen of chickens infected with these bacteria. This enhancing effect was reduced significantly when the immune globulins were absorbed with heat-killed Brucella cells to remove all the anti-Brucella agglutinins and immune adherence antibodies. (3) The passive transfer of rabbit antimycobacterial immunoglobulins directed against either living or soluble extracts of Mycobacterium tuberculosis strain H37Rv, promotes the multiplication of the BCG stain of M. tuberculosis in the spleen of mice infected with low doses of this latter strain. This enhancing effect was reduced significantly when antisera were absorbed with living BCG. Morever, such treatment led to the removal of all haemagglutinating antibodies when antisera were tested aganist either BCG or H37Rv soluble extracts.
The present paper is an attempt to get insight about the mechanisms involved in the enhancing phenomenon that occurs in bacterial infections. Mice infected with small doses of the BCG strain of M. bovis and treated with a M. tuberculosis H37Rv antiserum investigated at various intervals for their capacity to synthesize haemagglutinating antimyco-bacterial antibodies and to develop delayed hypersensitivity to PPD. As controls, BCG-infected mice were treated with the antiserum freed from its mycobacterial antibodies. It was found that the passive immunization of BCG-infected mice promotes the growth of bacilli in their spleen and induces a late formation of antimycobacterial antibodies which do not seem to be related to the development of delayed hypersensitivity.