[Nodular efflorescence and cutaneous vasculitis in rheumatoid arthritis treated with methotrexate].
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Biomedical subjects
Publications and source records attributed to A Fournie.
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The prevalence of thyroid abnormalities was determined in 131 patients: group I = rheumatoid arthritis, 68 patients, group II = systemic immunological diseases (IIa Sjögren's syndrome, n = 6; IIb other rheumatic autoimmune disease, n = 17), group III = other rheumatic diseases n = 13 and control group (n = 27). Thyroid abnormalities (hypo, hyperthyroidism, nodular goiter) were frequent: 33.8% in group I, 100% in group IIa, 11.7% in group IIb. Hypothyroidism was present in 19.1% (group I), 50% (group IIa). 6% (group IIb). Autoimmune thyroiditis was found in 16.2% in group I, 100% in group IIa, 11.7% in group III. Thyroid diseases are frequent in patients with rheumatoid arthritis. Therefore thyroid tests might be performed in patients with rheumatoid arthritis.
Two techniques can be used to achieve antenatal diagnosis of viral infections, i.e., amniocentesis and cord blood sampling. these procedures and their risks to the fetus are described in this article. Amniocentesis can be performed at the 15th week after the last menstrual period (LMP) under ultrasonographic guidance and carries a risk of fetal death of approximately 0.5%. Cord blood sampling, more difficult technically, can be performed at the 18th week after the LMP but is not useful for the antenatal diagnosis of infectious diseases before the 22nd or 23rd weeks. Fetal death rate is 0.5 to 1% when the procedure is performed by experienced operators. Other sampling methods, including fetal sampling and chorionic villus sampling can be used only in specific clinical situations. Situations in which ovum sampling is appropriate are outlined according to the circumstances of discovery of viral infections and the general problems raised. Emphasis is put on the need to use detailed protocols to perform these sampling procedures in order to minimize fetal risks and effectively exploit collected data.
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The authors report a case of pregnancy in a paraplegic patients whose lesion was at the level of T4. The patient showed minimal respiratory problems with a "heaviness" of her chest and asymptomatic urinary tract infections which did not affect fetal development. She had a normal delivery. The authors, from this case, wish to point out again that pregnancy in patients with spinal cord trauma are bedevilled by urinary tract infections, anaemia, bed sores, and the danger of hyper-reflexia of the autonomic nervous system which could affect the vital functions of the mother.
Two cases of maternal-fetal human parvovirus B19 infection are reported. The first case involved a feto-placental anasarca occurring during the third trimester and complicated by in-utero death with expulsion of a fetus with multiple malformations. The second case involved meconial peritonitis during the second trimester with favourable outcome after cesarean section and resolution of the digestive syndrome. Proof of PV B19 infection was obtained by identifying M specific immunoglobulins and viral DNA. After a review of the clinical situations most often encountered and the particular features of these two cases, therapeutic attitudes are proposed for this infection of major gravity during pregnancy.
The presence of autoantibodies reacting with lamins A and C was demonstrated in sera from 2 patients with rheumatoid arthritis (RA). One patient developed antilamin antibodies several years after being diagnosed as having RA; she was also found to have chronic active hepatitis. The second patient had severe nodular RA. We describe the other serologic findings in these 2 patients and discuss the relationships between antilamin antibodies and RA.
In 1988, 431 applications of Thierry's spatulae have been carried out at the Toulouse UCH (14% of deliveries). The indications, the modes of application and the results have been studied. The number of perineal tearings was slightly higher than that of spontaneous deliveries but quite comparable to the number recorded in university hospital departments which use other extraction instruments (namely Tarnier's forceps). 2 cervical lesions, against 1 in the spontaneous deliveries, and an equivalent number of vaginal lesions have been observed. However, the frequency of anaemias due to the bleeding during episiotomy, is clearly higher; this is due to the lack of experience of the operating staff. Finally, the ways of teaching the extraction techniques at the UCH are mentioned.
We report two cases of algodystrophy of the hip in pregnancy. The principle characteristics of the condition are: the occurrence of the symptoms in the second or third trimester of the pregnancy; and these are more marked on the left than on the right hip and radiological decalcification. MRI is accurate, specific and non invasive and it has largely taken the place of scintigraphy and tomodensitometry in making the diagnosis and in the differential diagnosis of early aseptic necrosis of the femoral head. Recovery always occurs in less than a year without sequelae. The physiopathogenic mechanism still is to be discussed but it does seem that the mechanical factors play a very important role.
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A 74-year-old woman with a primary thyroid plasmacytoma was studied. Clinical signs included a mass in the neck, as well as muscle and skin involvement due to dermatomyositis. In her serum a monoclonal IgG lambda was present. Immunohistochemistry showed an intracellular monoclonal IgG lambda component. After thyroid surgery and radiation, clinical improvement and fall of M protein were noted. On longterm followup, only palmar fasciitis persisted.
The authors describe a case of a desmoid tumor of the anterior abdominal wall. From a review of the world literature, the main characteristics of these tumors are detailed, and the various pathophysiological hypotheses, demonstrating the necessity of exclusively surgical treatment, are presented.
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