Biomedical subjects
A Francke
Publications and source records attributed to A Francke.
[Nursing activities. The nurse as factor within the healing climate. Interview by Toine de Graaf and Aart Eliens].
Explore the source record for details and available documents.
[Adaptive behavior of mature newborn infants following obstetric pain control with peridural fentanyl].
Obstetric pain relief using fentanyl epidurally is a safe and efficient method. In this study the effects of this obstetric analgesia on the adaptation pattern of 26 eutrophic newborns in the first hour of live have been estimated with cardiorespirograph in comparison with a normal groups. We did also determinations of acid-base-balance in arterial blood of umbilical artery and in hyperemic capillary blood of newborns. There were significant differences in basal frequency and the duration till the beginning of resting phase in the cardiorespirogramm. The differences to normal newborns may be correlated to the slight increase of partial pressure of carbon dioxide in the newborns following obstetrical analgesia. During the first hour of life newborns can good compensate. There is no sedation of newborns by fentanyl.
[Peridural analgesia with fentanyl--an alternative to control of labor pain].
Modern obstetrics should include not only an optimal labour monitoring but also an adequate pain relief during delivery. Due to the discovery of specific opiate receptors, for example in the substantia gelatinosa of the posterior horn in the spinal cord and the proof of direct pain-modifying effects on spinal level, new ways of the therapy of pain have been developed. The analysis was made with 40 parturients, who had decided for an epidural analgesia. They were given 0.1 mg fentanyl epidurally at a cervical dilatation of 3 to 5 cm and regular uterine contractions. The registrated onset time of fentanyl was between 6 and 15 minutes. A fentanyl dose of 0.1 mg applied epidurally proved to be sufficient for all parturients for the alleviation of pain in the period of dilatation. The interval without pain amounted to 130 mins. The motoricity was not impaired by the peridural application of fentanyl, because the parturient was able to be mobilized under continuous telemetric monitoring including telemetric management of the profile of the uterine activity. The period of the active and latent phases as well as the total delivery time was within the desirable ranges. An impairment of the general condition, e.g. vomiting, nausea or pruritus, was not noticed. There were no circulatory disturbances either. After the application of fentanyl the cardiotocograms remained uninfluenced in all parameters. All parturients declared that they had a positive birth experience under this kind of obstetric analgesia and that they would decide for this method again in case of a further delivery.
[Epidural administration of fentanyl--a possibility for controlling labor pain].
Explore the source record for details and available documents.
Cyclic peroxides from a soya lipoxygenase-catalysed oxygenation of methyl linolenate.
Incubation of methyl linolenate with an aqueous extract of soyabean flour at neutral pH gives the hydroperoxyendoperoxides 16-hydroxyperoxy-13,15-endoperoxylinolenate and 9-hydroxyperoxy-10,12-endoperoxylinolenate as the principal oxygenation products in addition to monohydroperoxides. Lipoxygenase I (EC 1.13.11.12) does not catalyse the oxygenation under this condition. The enzyme contributing most to the formation of the hydroperoxyendoperoxides is assumed to be a high molecular mass lipoxygenase aggregate.