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Biomedical subjects

A Fratila

Publications and source records attributed to A Fratila.

7 recordsLinked to original sources
PubMed1993

The differentiated surgical treatment of primary varicosis.

A differentiated surgical treatment of primary varicosis of the long and short saphenous veins, according to the type of varicosis, is necessary to avoid significant recurrence. The cosmetic results must also be taken into consideration. Knowing the most frequent types of primary varicosis and the principles of selective surgical treatment, the surgeon is able to perform a curative operation with a low complication rate and level of postoperative morbidity, high compliance, and excellent cosmetic results.

Humans↗
PubMed1993

Percutaneous minisurgical phlebectomy.

Percutaneous Minisurgical Phlebectomy is a safe and effective form of permanent treatment for side-branch varicosis in addition to other varicose veins (except the proximal part of the long saphenous vein) by means of multiple 1 to 2 mm incisions. The operation is performed using local anaesthesia in the outpatient department. There is no need for prophylaxis against thrombosis. Complications are rare and inconsequential.

Dissection↗
PubMed1990

Phenotypic and functional characterization of tumor infiltrating lymphocytes in mycosis fungoides: continuous growth of CD4+ CD45R+ T-cell clones with suppressor-inducer activity.

Tumor-infiltrating lymphocytes (TIL) were obtained by mechanical release from a solitary rapidly grown tumor of a patient with mycosis fungoides. The preparations separated by density gradient centrifugation contained a major portion of CD3+ CD8+ WT31+ CD5- large T-cell blasts and a minor portion of non-blastic TIL predominantly of the CD3+ CD4+ phenotype. Using cDNA-probes for the constant region of the T-cell receptor beta-genes, the large cell fraction was identified as tumor by its distinct monoclonal rearrangement. TIL were expanded by culture in recombinant interleukin 2 and cloned by limiting dilution. Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression. Cloned and uncloned TIL showed no NK and LAK activity, no proliferative response, and no cytotoxic activity against autologous tumor cells. These cells were unable to suppress the proliferative response of alloreactive T-cell clones stimulated by B-lymphoblastoid cell lines (i.e., they had no suppressor-effector activity), but strongly suppressed proliferation responses in allogeneic mixed lymphocyte culture (i.e., they most likely had suppressor-inducer activity). This was not the case when irradiated tumor cells were added. The present results demonstrate continuous in vitro growth of CD4+ and 2H4+ T-cell clones with suppressor-inducer activity obtained from TIL, and indicate that a subpopulation of TIL may down-regulate immune responses which may lead to suppression of antitumor immunity.

Antigens, CD↗
PubMed1990

[Value of Varady percutaneous microsurgical phlebologic extraction of varicose veins].

Varicectomy is a particularly useful procedure in the surgical treatment of varicose branch veins and perforating veins, since it allows selective estirpation without affecting the main trunk of the long saphenous vein (LSV). At the same time, there is usually no need of further sclerotherapy. The operation can be performed under local anaesthesia in the outpatient's department or, if a saphenofemoral junction insufficiency has to be simultaneously removed, during a short stay in hospital. The aesthetic results are remarkable. With the help of the new delicate instruments devised by Varady, the incisions are very small, making sutures unnecessary. All the varicose veins can be removed at once, there is no loss of blood and no need for prophylaxis against thrombosis and the postoperative ecchymosis is minimal. Thus the method can also be applied in elderly patients.

Anesthesia, Local↗