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A Frattasio

Publications and source records attributed to A Frattasio.

9 recordsLinked to original sources
PubMed2003

[Complications of pseudoainhum].

A 39 year old man presented with recurrent episodes of leukocytoclastic vasculitis and a large ulcer at the distal part of the stump of his right leg. Since birth the patient showed a clinical picture of pseudoainhum as part of the amniotic band syndrome (Simonart syndrome). Radiologic examination of the right foot showed only an hypoplastic talus and calcaneus which had been designated as a "stump":, which have been detected by x-ray. On both upper limbs there were missing phalanges, syndactyly and some constrictive fibrotic bands. Since the ulcer worsened with therapy, the patient underwent the amputation of the stump just below under the knee. Since then no further vasculitic lesions have been observed. We consider this case remarkable both because pseudoainhum is so rare and because of these equally unusual complications.

Adult↗
PubMed2001

Ofuji's disease: diagnostic and therapeutic problems. A report of three cases.

BACKGROUND: Ofuji's disease is an eosinophilic dermatosis affecting mostly male subjects. It is characterized by the appearance of follicular papulopustules, at times on an erytemathous base, which tend to form an annular configuration. The evolution is relapsing remitting. The histopathological examination demonstrates a dense dermal infiltrate with a prevalence of perifollicular and perivascular eosinophilia. Peripheral blood eosinophilia is observed in a high percentage of cases. The pathogenesis is unclear. METHODS: We report three cases of patients affected by Ofuji's disease with presentation on different sites. Our case reports concern three male subjects otherwise in good health and whose hematologic results were normal. Before they came to our observation, an erroneous diagnosis had been made and they had been subjected to improper treatment. RESULTS: To make a definite diagnosis it was necessary to evaluate the following features as a whole: the clinical aspect, the evolution, the result of the histological examination, the negativity of cutaneous cultures and the lack of response to previous treatments. All three patients were treated with dapsone 100 mg/day with regression of the clinical manifestations. In one case there was a relapse which was treated with isotretinoin 0.5 mg/kg/day. CONCLUSIONS: From our experience we can deduce that in cases of follicular pathologies which do not respond to conventional therapies, it is necessary to take into consideration the possibility of Ofuji's disease and, in that case, patients should be monitored because of the frequent relapses.

Adult↗
PubMed1999

Bilateral secondary syphilis of the tonsil.

A patient with bilateral tonsillar enlargement secondary to syphilis is presented. Clinical appearance, histological findings and serological tests permitted a correct diagnosis to be obtained, ruling out the suspicion of cancer.

Adult↗
PubMed1998

Surgery and cyclosporine A in the treatment of erosive lichen planus of the feet.

Erosive lichen planus is known to be relatively unresponsive to medical treatment. Surgery could be an alternative treatment for this disease. We report the case of a 68-year-old man with a 10-year history of painful, disabling, ulcerative lesions on the soles of both feet. All previous topical and oral treatments had failed and his condition was gradually worsening. Cyclosporine A was administered twice. The first time, systemic cyclosporine A gave a marked but only temporary improvement. The second time, treatment with cyclosporine A was begun 10 days before the ulcer on his left sole was covered with a Thiersch split-skin graft. The grafting was successful, so cyclosporine A was gradually reduced to smaller maintenance doses and 10 months later it was completely withdrawn. The patient refused to undergo surgery on his right foot thus providing the opportunity to compare the results. At the present time, eighteen months following grafting and ten months after total withdrawal of cyclosporine A, the condition of the left sole is stable and free from pain while the ungrafted ulcer on his right sole is still painful and has increased in size.

Aged↗
PubMedDate not supplied

Gorlin's syndrome. Case report.

Gorlin's syndrome (GS) is a hereditary dominant autosomal disease linked to a gene which has a strong discerning and an extremely variable expressiveness. It is an ecto-mesodermic polydysplasia generally characterized by multiple nevoid basal-cell carcinomas, palmo-plantar pits, cysts of cutis and long bones, intracranial ectopic calcification; less frequently it is accompanied by tumors of other organs such as the ovaries, and by brain, neurological and ocular defects. Chalazions and squinting are the most typical ocular complications. We describe a patient with GS detected at an ophthalmology consultancy during which by chance we found multiple peripheral retinal breaks with a partial retinal detachment and retinoschisis.

Adult↗