Biomedical subjects
A Friedlander
Publications and source records attributed to A Friedlander.
Antigenic complexes of steroid hormones formed by coupling to protein through position 7: preparation from 4 -3-oxosteroids and characterization of antibodies to testosterone and androstenedione.
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Specificity of antibodies to ovarian hormones in relation to the steroid hapten to the peptide carrier.
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Antibodies to steroids coupled to protin through ring B and their use in the radioimmunoassay of gonadal hormones.
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Kinetics of synthesis of cytoplasmic RNA with transfer properties in cultures of adrenal tumor cells.
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Pseudouridine content of rapidly synthesized 4-S RNA from adrenal tumor cell cultures.
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Investigations on the chemistry of heparin. VI. Position of the sulfate ester groups.
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Precise determination of paraspinous musculature by quantitative CT.
The ability to quantify muscular size has important implications in monitoring the effects of muscle disorders, in assessing the efficacy of interventions aimed at abbreviating muscle atrophy, and in examining the association between muscle and bone as a correlate of osteoporosis. We have developed an autocontouring technique for the precise determination of paraspinous musculature that can be implemented as an adjunct to our current CT method of spinal trabecular densitometry without additional scanning time or radiation exposure. Using two distinct patient groups, we evaluated the validity of this technique by assessing intra- and interobserver variability. Using the average coefficient of variation (CV) as an estimate of precision, we found intraobserver variability to be essentially equivalent whether evaluated in young, healthy men (0.69%) or in older, mildly osteoporotic women (0.74%). When the muscle evaluations of two observers were compared, the variability was somewhat higher, 1.81 and 1.83% in older and younger subjects, respectively. We scanned an additional 10 subjects twice, with intermediate repositioning, and found the reproducibility (CV) of determining paraspinous muscle area to be 0.97%. Given this estimated high level of precision, we derived the approximate magnitude of change in muscle size that could be observed using two-point measurements in time. Small average changes, on the order of 1-2%, could be detected using small groups of subjects (10-20/group). Moreover, we found that, even in the individual patient, relatively small changes (3-6%) could be detected given our low imprecision estimate. We believe this quantitative approach holds promise for monitoring muscle changes in vivo as well as for rigorously exploring the relationship between muscle and bone.
Cementing pins with cyanoacrylate (an appraisal of biodegradability).
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Lactobacillus acidophillus and vitamin B complex in the treatment of vaginal infection.
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Leptospiral agglutinating factor in turtles. Further studies on fractionated sera.
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Ergonovine test in coronary disease.
The authors present the role of the Ergonovine test in establishing the diagnosis of the angina produced by coronary spasm. ECG alterations induced by Ergonovine, like transparietal ischemia (monophasic wave) or subendocardic ischemia, not only make possible a correct diagnosis, but they also underline the mechanism of angina and the therapeutical measures. Severe arrhythmias and the danger of sudden death are the two elements illustrating the importance of this coronary spastic mechanism. Nitroglycerine, isosorbidinitrate and calcium antagonists are the drugs of election for the prevention and also for the treatment of coronary spasm.