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Biomedical subjects

A Frković

Publications and source records attributed to A Frković.

26 records · Page 2Linked to original sources
PubMedDate not supplied

[Potassium diffusion potentials in fetal erythrocytes and leukocytes in umbilical cord blood].

The potential of the membrane erythrocytes and leucocytes from the fetal umbilical cord blood was studied in order to determine the vitality of cells. The membrane erythrocytes potential was analysed in 11 blood samples of normal deliveries and 3 blood samples of deliveries with the meconium amniotic fluid; the membrane leucocyte potential was examined in 16 blood samples of normal deliveries and 5 blood samples of deliveries with the meconium amniotic fluid. The method used was the indirect fluorescence spectroscopy and the cyanin dye DIO-C5-(3) as the extrinsic fluorescent probe. In deliveries with the meconium amniotic fluid, leucocyte and erythrocyte membranes continue maintaining the potassium potential. The reactions of erythrocytes and leucocytes to the addition of valinomycin are entirely different: in the leucocytes of fetuses with the meconium amniotic fluid the membrane is more polarized than in fetuses from normal deliveries, whereas in the erythrocytes of fetuses with the meconium amniotic fluid the membrane polarization is less pronounced.

Erythrocyte Membrane↗
PubMedDate not supplied

[The effect of prostaglandin F2 alpha and indomethacin on the musculature of the human appendix].

In their research, the authors have tried to determine possible differences in effects of prostaglandin F2 alpha on longitudinal musculature tonus in normal and inflamed human appendix and the extent to which it is possible to react on prostaglandin effect by indomethacin. The obtained results indicate that PGF2 alpha increases tonus in human appendix musculature; however, the change is more pronounced in a normal appendix musculature. Even more, indomethacin prevents spasms caused by PGF2 alpha in musculature of both normal and inflamed appendix significantly. This indicates that, in addition to its influence on prostaglandin synthesis indomethacin also has another mechanism of activity, may be even at the level of prostaglandin receptors.

Appendix↗
PubMedDate not supplied

[The effect of histamine and histamine H1 and H2 receptor blockers on the tone of the longitudinal muscles in the human appendix].

The aims of this study were to determine whether the effect of histamine on a smooth musculature of the human appendix is mediated by histamine H1-receptors only or whether histamine H2-receptors are involved, as well. The obtained results indicate histamine increases tonus in musculature; however, histamine H1-receptor antagonist (promethazine) decreases tonus. Histamine H2-receptor antagonist (cimetidine) has caused a mild increase in tonus of musculature what indicates that it has a certain intrinsic activity. By blocking histamine receptors with H1 and H2 antagonists which were used either separately or together before cumulative histamine concentrations, it has been concluded that histamine actions are exerted not exclusively by H1-receptors but also histamine H2-receptor antagonists can significantly decrease the tonicizing effect of histamine.

Appendix↗
PubMedDate not supplied

[The effect of prostaglandin F-2 alpha and indomethacin on the longitudinal musculature of the human oviduct].

The musculature of the isthmic and ampullar segment of the human oviduct reacts to Prostaglandin F-2 alpha by the increased tonus. The tonus increased was more pronounced in the musculature of the gravid oviduct. Prostaglandin F-2 alpha in the presence of Indomethacin products a significantly lower tonus increase of the musculature of the isthmic and ampullar segment of the non-gravid human oviduct than is the case when applied alone.

Dinoprost↗
PubMedDate not supplied

[Effect of histamine and its antagonists on the muscular tone of the non-pregnant uterus in the woman].

In the isolated strips of the individual parts of the human uterus (body, corns, cervix) histamine, promethazine, and cimethidine, proportionally to the dose applied, have proved to increase the muscular tonus. The blocking agents of histamine H-1 receptors (promethazine) and H-2 receptors (cimetidine), separately or jointly administered in the dose of 10 micrograms/ml, significantly diminish the tonicizing effect of histamine. The effect of histamine on the uterine muscular tonus is brought about through histamine H-1 and histamine H-2 receptors.

Female↗
PubMedDate not supplied

[Effect of histamine and its antagonists on the muscle tone of the body of the non-pregnant and pregnant human uterus].

In the uterus body of nongravid and gravid women, proportionally to the dose used, histamine, promethazine, and cimetidine produce an increased muscular tonus, which is more pronounced in gravid uteri. The blocking agent of histamine H-1 receptors, promethazine, and the blocking agent of histamine H-2 receptors, cimetidine, separately or jointly applied in a dose of 10 micrograms/ml, significantly decrease the tonicizing effect of histamine. Histamine exerts its influence on the muscular tonus of the body of nongravid and gravid human uteri through histamine H-1 and histamine H-2 receptors.

Female↗