Hemodynamics of the terminal vascular bed in canine hemorrhagic shock.
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Biomedical subjects
Publications and source records attributed to A Fronek.
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The association of peripheral arterial disease (PAD) with hostility, a component of Type A behavior, has not been investigated. Previous studies have found an association between coronary arterial disease and hostility. We used Doppler tests to define PAD as consisting of a resting index less than 0.9, absence of posterior tibial waveform, or presence of a femoral bruit. Among 4,462 male veterans, the prevalence and odds ratio of PAD increased statistically significantly with an increase in the Cook-Medley hostility scale. The prevalence of PAD was 0.7%, 1.1%, 1.4%, and 1.6% in the first, second, third, and fourth quartiles of the hostility scale, respectively. Using the first quartile as a reference group, we found that odds ratios of PAD were 1.6, 1.9, and 2.2 for the second, third, and fourth quartiles, respectively. Odds ratios, adjusted for age, race, cigarette smoking, hypertension, familial ischemic heart disease, diabetes, and elevated LDL/HDL were 1.4, 1.6, and 1.8, respectively. The magnitude of the odds ratios and their statistically significant trend suggest an association between PAD and hostility.
Power Frequency Spectral Analysis (PFSA) which evaluates the power of the frequency components at a selected interval, was applied in this preliminary study using a 5MHz Doppler continuous wave flow velocity meter and a modified Edwards Spectraview 500 analyzer. PFSA was used to study the common, internal and external carotid arteries of ten young adult control subjects and 31 patients with angiographically documented carotid bifurcation lesions. Two useful indices are described: (1) the frequency band width at 50% of maximum power (f50%) and (2) the highest frequency recorded (fmax). An f50% wider than 1900 Hz (corresponding to spectrum broadening) identified stenoses as low as a 15% diameter reduction. An fmax higher than 6500 Hz practically always indicated a 50% or greater diameter reduction. Eighty two percent of stenoses with 11-25% diameter reduction were detected, as were 95% of stenoses from 36-50%. All stenoses from 51-99% were identified.
Carotid arterial disease was investigated with a Duplex Scanner using Power Frequency Spectrum Analysis. Sixty-one carotid systems were evaluated noninvasively and angiographically, while 20 controls were examined and assumed to be normal. Peak frequency and 50% frequency bandwidth, a quantitative index of spectral broadening, were correlated with the percentage of stenosis. Peak frequency predicted the presence or absence of hemodynamically significant stenoses (greater than or equal to 50% diameter reduction) with 90.8% accuracy, while 50% frequency bandwidth correctly identified similar lesions with 93.2% accuracy (p = NS). Also, with the latter results, carotid systems were grouped into less than 25%, 25% to 49%, and greater than or equal to 50% stenosis categories with an 86.4% accuracy. Similar statistical evaluation was attempted for peak frequency results. It was not possible to separate hemodynamically insignificant lesions (less than 50% diameter reduction) into distinct groups because of the overlap of results among those arteries with less than 50% stenosis. Finally, all eight occluded internal carotid arteries were identified with combined Doppler/imaging analysis. However, with imaging alone, only 5 of 8 (63%) occluded arteries were correctly identified.
The clinical application of Doppler velocity measurement is reviewed as a diagnostic tool in arterial disease of the lower extremity. Emphasis is placed on the importance of quantitative evaluation of the recorded tracings. Various aspects of qualitative, semi-quantitative and quantitative evaluation are discussed. Included are also some more special applications as pedal arch examination, profunda femoris and penile arteries velocity evaluation.