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Biomedical subjects

A Frosh

Publications and source records attributed to A Frosh.

At least 19 recordsLinked to original sources
PubMed2006

Functional rhinoplasty with batten and spreader grafts for correction of internal nasal valve incompetence.

OBJECTIVE: We a describe technique for correction of internal nasal valve incompetence (INVI) using functional rhinoplasty (FRP) with combined cartilaginous batten and spreader grafts and report the functional and cosmetic outcomes. DESIGN: Prospective series using subjective improvement in nasal airway and quality of life. SETTING: Subregional ENT centre, one operating rhinologist. PARTICIPANTS: Twenty-three consecutive adults presenting to ENT department at North Hertfordshire NHS Trust with symptomatic INVI. MAIN OUTCOMES MEASURES: Pre and post-operative symptom scores for nasal obstruction and its impact on overall quality of life using visual analogue scales (1-100mm). Cosmetic outcome graded using subjective scores. Statistical analysis performed using the Wilcoxon signed rank test. RESULTS: We found a median subjective improvement on the visual analogue scale of 55 mm for nasal patency (p<0.001) and of 49 mm for quality of life (p<0.001). Twenty-two patients felt that the appearance of their nose had not changed or had significantly improved post operatively. CONCLUSION: Combined use of batten and spreader grafts for the correction of INVI in normal or narrow nasal vaults is effective without compromising cosmesis.

Cartilage↗
PubMed2005

Cophenylcaine spray vs. placebo in flexible nasendoscopy: a prospective double-blind randomised controlled trial.

Practices vary across the UK on the use of topical preparation prior to flexible fibreoptic nasendoscopy. In this double-blind study, we randomised 98 patients to receive cophenylcaine or placebo nasal spray before flexible nasendoscopy. A visual analogue scale (1-100) was used to record pain, unpleasantness of taste and overall discomfort experienced. Overall, the procedure was associated with minimal pain and discomfort in both groups. There was no significant difference in pain or overall discomfort experienced between the two groups; however, the sensation of bad taste was significantly worse in the cophenylcaine group. In linear regression, factors that predicted the overall unpleasantness of the experience were primarily pain experienced and secondarily unpleasantness of taste. We conclude that the routine use of cophenylcaine for nasal preparation is not justified before flexible nasendoscopy.

Administration, Intranasal↗
PubMed2004

Laryngeal cleft type I: a novel method of repair using Bioplastique.

The authors report a novel treatment of a case of type I laryngeal cleft diagnosed in an adult. They describe a technique of endoscopic obliteration of the posterior commissure defect. Initially, a test implant of starch and adrenaline was used, followed by permanent staged injections of Bioplastique to the posterior commissure. This rare congenital anomaly usually presents in childhood but late presentation should be considered when adults present with lifelong dysphonia especially when associated with gastro-oesophageal reflux disease.

Adolescent↗
PubMed2003

Silver nitrate: histological effects of cautery on epithelial surfaces with varying contact times.

Silver nitrate is used extensively in rhinological practice for the treatment of recurrent epistaxis. There are currently no recommendations in the literature regarding the optimum application time of this chemical for effective treatment. We assessed the histological effects of silver nitrate on mucosal tissue at varying contact times and made recommendations based on our findings. Silver nitrate was applied at predetermined contact times to tonsillar mucosa, immediately before tonsillectomy in subjects undergoing routine surgery. The cauterized areas were subsequently analysed histologically. The depth of tissue penetration by the silver nitrate was measured. The means for 5, 10 and 20 s were 0.44, 0.30 and 0.38, respectively, P = 0.3. Overall, there was no deeper penetration of the tissues with contact times over 5 s. We conclude that it is not necessary to apply silver nitrate for greater than 5 s to achieve maximal tissue penetration.

Anti-Infective Agents, Local↗
PubMed2001

Sensorineural hearing loss in linear IgA disease.

A 23-year-old female with progressive sensorineural hearing loss developed widespread blistering eruptions while under evaluation for the hearing loss. The lesions showed findings characteristic of linear IgA disease (LAD) on histochemical studies. Linear IgA disease is a dapsone responsive autoimmune subepidermal blistering disease characterised by linear IgA deposits in the basement membrane zone. The complete spectrum of this systemic disease is still not clear and this is the first report of association between LAD and sensorineural deafness.

Adult↗
PubMed2000

Post-tonsillectomy patient care in the community.

Tonsillectomy is a frequently performed surgical procedure. Problems arising in the early postoperative period will have an important impact on community and hospital resources. We determined the type of problems that occur and the way these problems are managed. We monitored 203 patients undergoing routine tonsillectomy by a postoperative telephone survey and contacted their general practitioners, 164 in all. We found 46% of the patients experienced problems post-discharge which led to early contact with a doctor. Infection was identified in 26% and secondary haemorrhage in 11%. Common symptoms associated with the prescribing of antibiotics were sore throat (74%) and secondary haemorrhage (41%). Each GP saw, on average, 2.4 post-tonsillectomy patients per annum. The diagnosis of post-tonsillectomy infection is difficult. This was reflected in the wide variation of clinical features used to diagnose post-tonsillectomy infection by doctors. The vast majority (95%) of GPs expressed a desire for a framework for treating post-tonsillectomy complications.

Adult↗
PubMed1999

Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples.

BACKGROUND: Prion diseases are associated with the accumulation of an abnormal isoform of cellular prion protein (PrPSc), which is the principal constituent of prions. Prions replicate in lymphoreticular tissues before neuroinvasion, suggesting that lymphoreticular biopsy samples may allow early diagnosis by detection of PrPSc. Variant Creutzfeldt-Jakob disease (variant CJD) is difficult to distinguish from common psychiatric disorders in its early stages and definitive diagnosis has relied on neuropathology. We studied lymphoreticular tissues from a necropsy series and assessed tonsillar biopsy samples as a diagnostic investigation for human prion disease. METHODS: Lymphoreticular tissues (68 tonsils, 64 spleens, and 40 lymph nodes) were obtained at necropsy from patients affected by prion disease and from neurological and normal controls. Tonsil biopsy sampling was done on 20 patients with suspected prion disease. Tissues were analysed by western blot to detect and type PrPSc, by PrP immunohistochemistry, or both. FINDINGS: All lymphoreticular tissues obtained at necropsy from patients with neuropathologically confirmed variant CJD, but not from patients with other prion diseases or controls, were positive for PrPSc. In addition, PrPSc typing revealed a consistent pattern (designated type 4t) different from that seen in variant CJD brain (type 4) or in brain from other CJD subtypes (types 1-3). Tonsil biopsy tissue was positive in all eight patients with an adequate biopsy sample and whose subsequent course has confirmed, or is highly consistent with, a diagnosis of variant CJD and negative in all patients subsequently confirmed to have other diagnoses. INTERPRETATION: We found that if, in the appropriate clinical context, a tonsil biopsy sample was positive for PrPSc, variant CJD could be diagnosed, which obviates the need for a brain biopsy sample to be taken. Our results also show that variant CJD has a different pathogenesis to sporadic CJD.

Adolescent↗
PubMed1999

Effect of chewing gum on recovery after tonsillectomy.

OBJECTIVE: Patients are traditionally advised to eat early and frequently in the initial post-tonsillectomy period to reduce the severity of pain and to facilitate early resumption to a normal diet. We investigated the action of mastication and therefore the promotion of saliva formation and deglutition on the post-operative recovery of tonsillectomy patients. METHODS: We present a prospective randomised controlled trial set up to observe the effects of chewing gum on these patients. One hundred and two patients undergoing routine tonsillectomy for recurrent tonsillitis were randomised into cases (those given chewing-gum) and control groups (those not given chewing-gum). Eighty-four patients were reviewed on the seventh post-operative day. We measured the time taken in days for the subjects to resume to their normal diet after surgery and measured pain on a daily basis. RESULTS: Our study demonstrated that chewing gum in the early post-operative period significantly delayed resumption of normal diet (Chi-squared test with Yates' correction, chi2= 4.6, P = 0.032). Chewing gum also increased the average amount of pain experienced by the cases over the controls and this became statistically significant on day 7 (mean difference = 14.8, t-test with two tailed probability, P = 0.041). CONCLUSION: We conclude that chewing gum should not be routinely advised in the early period following tonsillectomy.

Adolescent↗
PubMed1999

Prions and the ENT surgeon.

Recent developments in our understanding of prion diseases have raised concerns for the public health. There is now compelling evidence that the transmissible agent for variant Creutzfeldt-Jakob disease (vCJD) in affected individuals is accumulated in lymphoreticular tissues such as the appendix and tonsils. This agent demonstrates a remarkable resistance to standard methods of sterilisation used in hospital sterile services departments. The possible implications this has on the safety of surgical instruments in ENT and other surgical practice is discussed. This review also outlines the history of our understanding of prion diseases and describes the development of a diagnostic test for vCJD in the living patient by pharyngeal tonsil biopsy.

Biopsy↗
PubMed1997

Tracheal ring rupture and herniation during percutaneous dilatational tracheostomy identified by fibreoptic bronchoscopy.

We present a case of rupture and herniation of cartilaginous tracheal rings into the lumen of the trachea that was noticed as an incidental finding during bronchoscopy after percutaneous dilatational tracheostomy. While percutaneous methods of tracheostomy formation gain popularity in intensive care settings, the number of reported problems associated with this technique continue to grow. We propose that fibreoptic bronchoscopy used routinely with percutaneous tracheostomy formation will identify a number of complications involving the tracheal skeleton.

Aged↗
PubMedDate not supplied

The Foley catheter in the management of epistaxis.

The Foley urinary catheter has been used in the management of epistaxis for many years, yet it has never been designed or licensed for this purpose. We performed a telephone questionnaire of senior house officers in 90 ENT departments in England and Wales. The aim was to determine how many departments used the Foley catheter for epistaxis management, whether licensed nasal balloon devices were available and if there had been any complications associated with their use. Eighty-three (92%) ENT departments in the study used the Foley catheter for epistaxis management and 44 (49%) departments had licensed balloon devices available. Only 22% of ENT senior house officers questioned were aware that the Foley catheter was not licensed for use in the nose. Most complications associated with the use of nasal balloon devices appear to be due to Foley catheters.

Catheterization↗
PubMedDate not supplied

Emergency tracheostomy in general practice.

We set out to review the need for general practitioners (GPs) to be skilled at forming an emergency alternative airway by assessing mortality figures for acute airways obstruction. We also solicited the views of 100 GPs on the theory and practice of emergency tracheostomy and assessed whether they considered they were equipped to carry out such a procedure in the community. The results suggest a significant number of deaths of otherwise young and healthy individuals could be avoided by training community practitioners in emergency alternative airway formation. The results showed a marked lack of confidence in the practice of emergency airway formation and few GPs felt able to carry out the procedure. They indicated an overwhelming interest in receiving further education on the subject. We recommend that formal training programmes in the techniques of emergency airway formation should be available for community GPs.

Airway Obstruction↗