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Biomedical subjects

A Frumkin

Publications and source records attributed to A Frumkin.

At least 37 records · Page 2Linked to original sources
PubMed1991

Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel.

Three women and one man aged forty-one to sixty-five years experienced a severe burning sensation following the application of aloe vera or vitamin E preparations to a skin area that had been subjected to a chemical peel or dermabrasion. Subsequently, a severe dermatitis occurred that required hospitalization of one patient and intravenous administration of steroids. The dermatitis abated very slowly in all patients: full recovery took three months or more. One patient resumed the use of vitamin E creams two years after the episode of dermatitis and experienced no adverse effect. Patients undergoing dermabrasion or chemical peel procedures should be cautioned specifically against the use of aloe vera or vitamin E topically in the first weeks after surgery.

Adult↗
PubMed1989

The chicken homeo box genes CHox1 and CHox3: cloning, sequencing and expression during embryogenesis.

Several Drosophila genes involved in the control of segmentation and segment identity share a 183-bp conserved sequence termed homeo box. Homeo box sequences have been detected and cloned from the genomes of insects like Drosophila to vertebrates such as mouse and man. Two chicken homeo box genes CHox1 and CHox3, are described. Cloning of the CHox1 and CHox3 homeo boxes was performed using Drosophila and murine homeo box sequences as probes under low-stringency conditions. Analysis of both chicken homeo box sequences revealed them to be homeo boxes that have diverged from the Antennapedia class with homologies to homeo boxes of other organisms in the range of 75-42% at the nucleotide level and 69-41% at the protein level. Analysis of CHox3 expression during early embryo development showed that the gene codes for five transcripts 1.3, 1.9, 2.6, 5.6 and 7.9 kb in size. Three of the transcripts (1.3, 1.9 and 5.6 kb) are also recognized by a flanking non-homeo box containing probe. The levels of the different transcripts changed during the first five days of development. The most abundant transcripts (1.3 and 1.9 kb) are already present at the time the egg is laid. Their transcription peaks at day 1 of incubation and then decreases. The CHox1 transcripts are present at very low levels between days 2.5 and 4 of development. These two chicken genes represent bona fide Hox genes in a branch of vertebrates that evolved parallel to mammals.

Amino Acid Sequence↗
PubMed1989

Sporotrichosis in a father and son.

A 41-year-old man developed classic lymphocutaneous sporotrichosis on the left arm; his 2-year-old son developed a single lesion of the "fixed" type on the right leg. Both patients responded rapidly to therapy with oral potassium iodide. Seven previous reports of familial sporotrichosis are listed, and therapy is reviewed briefly.

Adult↗
PubMed1989

Tinea capitis caused by Microsporum praecox in a patient with sickle cell anaemia.

Microsporum praecox Rivalier ex Padhye, Ajello et McGinnis is the validated name for the taxon originally published as Sabouraudites praecox Rivalier. We describe here the first case of small-conidial, ectothrix type hair invasion caused by M. praecox in an adult woman from Oklahoma, U.S.A., suffering from sickle cell anaemia. This fungus is now being encountered with greater frequency as an etiologic agent of ringworm infection.

Adult↗
PubMed1989

Nocardial infections in Israel: a survey.

Six cases of pulmonary nocardiosis and 11 cases of cutaneous and soft tissue nocardiosis have been reported in Israel since 1965. All three pathogenic species, Nocardia asteroides, N. brasiliensis and N. caviae, were implicated. About one-half of the patients were immunosuppressed at the time of diagnosis. Three patients died. The importance of a high level of awareness is emphasized as well as the need to observe cultures for a few weeks to allow for the slow growth of Nocardia species.

Adult↗
PubMed1988

Pseudotumor cerebri caused by isotretinoin.

A 16-year-old girl treated with isotretinoin at a dosage of 0.7 mg per kg each day experienced severe headaches and impaired night vision two months after the start of therapy. Bilateral papilledema and narrowing of the lateral ventricles of the brain were found. Pseudotumor cerebri and impaired night vision abated when isotretinoin was discontinued and systemic corticosteroids (dexamethasone) were administered.

Acne Vulgaris↗
PubMed1988

Delayed reaction to "lead" pencil simulating melanoma.

A 74-year-old man had sustained a penetrating lead pencil injury to his right lower leg at the age of fifteen. A dark gray macule occurred that remained unchanged for fifty-eight years. An enlarging black nodule appeared in this area, simulating a melanoma, when the patient was seventy-three years old. Histologic examination revealed exogenous pigment and a foreign body reaction.

Aged↗
PubMed1988

Erythema annulare of infancy.

A case of erythema annulare of infancy lasting for two years is presented. The striking features of this overall annular eruption, of idiopathic origin, are noted. This case is unusual because of the late onset and the long duration of symptoms. Such cases warrant prolonged follow-up examinations after the annular lesions disappear.

Erythema↗
PubMed1987

Phenol cauterization of nail matrix remnants.

Incomplete destruction of the nail matrix may result in partial recurrence of the nail. This occurs most frequently at the lateral ends of the proximal nail fold. A procedure that provides permanent, satisfactory results consists of careful dissection of the recurrent nail fragments followed by local phenol cauterization.

Cautery↗
PubMed1987

Juvenile xanthogranuloma underneath a toenail.

A 1 1/2-year-old boy developed a dystrophic toenail shortly after trauma to the foot. At the age of three years, it was recognized that the nail deformity was caused by a subungual tumor. The tumor proved to be a juvenile xanthogranuloma. The lesion was solitary, and no systemic associations or visceral involvement were found.

Child, Preschool↗