Biomedical subjects

A Fujinuma

Publications and source records attributed to A Fujinuma.

3 recordsLinked to original sources

PubMed1987

[Ultrastructural study of osteosarcoma].

Twenty one cases of common type of osteosarcoma were investigated light and electron microscopically. Ultrastructurally, osteosarcoma could be classified into 4 types of cells, osteoblast-like, chondroblast-like, fibroblast-like and small round cell types. Another type of tumor cells, occasionally encountered in the tumor tissue, were myofibroblastic, osteoclastic and filopodial cells of subdivided groups. All of these were constituents of groups of tumor tissue, and were histopathologically manifested with osteoblastic, chondroblastic, fibroblastic and small round cell types of each predominant cell groups, respectively. However, the main tumor cells essentially consisted of osteoblast-like cell with prominent osteoid formation; hydroxyapatite with dense crystalline structure was characteristically deposited in the dense collagenous matrix. Osteoids also showed several structural varieties of matrix vesicles. These structural relationship to the osteoid were also discussed.

Adolescent↗

PubMed1986

Ultrastructural study of a clear cell chondrosarcoma.

A lesion in the left humeral head of a 15-year-old Japanese boy was light-microscopically diagnosed as clear cell chondrosarcoma. Fresh tissues from the lesion were studied ultrastructurally. In most tumor cells, that is, clear cells, paucity of organelles, sparse free ribosomes, and low protein content in cytosol were most striking. Tumor cells had many microvilli characteristic of cartilage cells. Among scanty organelles, vesicles or cisternae of dilated rough endoplasmic reticulum were rather conspicuous, and well-developed Golgi complexes were sparse. Intercellular matrix was scanty. These results suggest that intercellular matrix substance may be synthesized substantially by rough endoplasmic reticulum, whereas the synthesized substance perhaps cannot be transported smoothly into extracellular spaces because of scanty well-developed Golgi complexes.

Adolescent↗

PubMed1984

[Effect of porcine calcitonin on pain caused by cancer-induced bone destruction].

The analgesic effect of porcine calcitonin (PCT) was studied in 32 patients with cancer-induced bone destruction. Twenty patients (62.5%) showed some response among them 10 of 13 patients who had suffered from uncontrollable pain despite other treatment methods such as radiotherapy, and or the administration of other analgesics. The effect was observed about 10 days after the administration of the drug. Combined therapy with PCT and other modalities such as radiotherapy, chemotherapy and hormone therapy had a marked effect in controlling the pain.

Adolescent↗