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Biomedical subjects

A Furst

Publications and source records attributed to A Furst.

At least 73 records · Page 4Linked to original sources
PubMed1978

Tumorigenic effect of an organomanganese compound on F344 rats and Swiss albino mice.

Trioctanoin suspensions of manganese dioxide and manganese powder were injected im into inbred F344 rats and Swiss albino mice. The manganese powder was also administered orally to the rats. No difference in tumor incidence was noted between treated and control animals. In contrast, manganese (manganous) acetylacetonate administered im to rats produced a statistically significant number of fibrosarcomas at the sites of injection.

Animals↗
PubMed1977

An evaluation of D-glucosamine as a gratuitous catabolite repressor of Saccharomyces carlsbergensis.

Glucose represses mitochondrial biogenesis and the fermentation of maltose, galactose and sucrose in yeast. We have analyzed the effect of D-glucosamine on these functions in order to determine if it can produce a similar repression. It was found that glucosamine represses the respiration rate (QO2) but more rapidly than glucose and to a final level slightly higher than in glucose-treated cells. Derepression of the respiration rate following either glucose or glucosamine repression was similar. A two hour lag was followed by a linear increase in QO2 to the derepressed level. Both glucose and glucosamine repressed the level of cytochrome oxidase to the same level. Glucosamine was also found to repress maltose and galactose fermentation but not sucrose fermentation. The derepression of maltase synthesis was inhibited by glucosamine. The constitutive synthesis of maltase was repressed by the addition of glucosamine. Glucosamine was judged to produce a repressed state similar to glucose repression in many respects.

Electron Transport Complex IV↗
PubMed1976

In vitro inhibition of aryl hydrocarbon hydroxylase by heavy metals.

Inhibition of mouse hepatic aryl hydrocarbon hydroxylases (AHH), microsomal mixed-function oxidases was obtained with five bivalent metal chlorides. Concentrations ranged from 10(-6) to 10(-1) m. The enzyme system was induced by an intraperitoneal injection of a trioctanoin solution of 3-methylcholanthrene into C57B1/6J mice 24 hours before the hepatic AHH was measured. Activity was calculated as: ng of 3-hydroxybenzo(a)pyrene formed in 20 min at 37 degrees C per mg of protein. Cadmium was the most inhibitory of the metals tested. Zinc inhibited the enzyme system more than iron, manganese, or nickel. At 10(-4) m, ferrous ion slightly stimulated the activity, but at 10(-5) and 10(-3) m, it was inhibitory. Manganese failed to stimulate the enzyme activity as reported by others.

Animals↗
PubMed1976

Tumorigenic activity of lead chromate.

Lead chromate was investigated for its carcinogenic potential in both rats and mice. Results show that this compound is a very potent carcinogen in rats when administered i.m. Sixty-four % of the animals treated developed malignant tumors at the injection site. Three renal carcinomas were also found after i.m. treatment with lead chromate. Since lead powder is a comparatively weak carcinogen in rats, whether given p.o. or i.m., it is suggested that the combination of lead and chromium (also weak carcinogen) accounts for the high carcinogenic activity of lead chromate in rats. Swiss albino female mice could not tolerate the same high dose level as did the rats; at the lower dose administered to the mice, no tumors were detected.

Animals↗