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Biomedical subjects

A G Antonopoulos

Publications and source records attributed to A G Antonopoulos.

4 recordsLinked to original sources
PubMed1990

Exercise testing for assessment of the significance of ST segment depression observed during episodes of paroxysmal supraventricular tachycardia.

Sixteen patients who had manifested ST segment depression during episodes of paroxysmal supraventricular tachycardia (PSVT) were studied with exercise testing in order to detect coronary artery disease and myocardial ischaemia. No ST segment depression was observed during exercise testing in 15 out of the 16 patients tested. Paroxysms of supraventricular tachycardia associated with ST segment depression occurred during exercise testing in three cases. The ST segment depression was immediately apparent, remained constant throughout the supraventricular tachycardia and was almost instantly abolished following conversion to sinus rhythm. Patients with heart rates greater than 250 beats min-1 during PSVT had marked ST segment depression associated with the tachycardia. These results suggest that coronary artery disease and myocardial ischaemia are not involved in the genesis of ST segment depression during PSVT. Tachycardia per se may be the cause of ST segment depression by altering the slope of phase 2 of the ventricular action potential. Retrograde atrial activation may also induce ST segment shifts in some of the cases.

Adolescent↗
PubMed1987

The effect of coronary revascularization on exercise-induced ventricular ectopic activity.

The effect of coronary artery bypass graft surgery (CABGS) on the prevalence of exercise-induced ventricular ectopic activity was studied in 43 patients (42 male, 1 female). Their age was 53 +/- 7.8 (mean +/- SD) years. Treadmill exercise test (TET) was performed within a month prior to and three months post-CABPGS. An average of 2.8 grafts per patient were used. Nine of the 43 patients (20.9%) had premature ventricular contractions (PVCs) related to effort prior to CABGS, while 12 out of the 43 (27.9%) had PVCs post-surgery. Seven patients (16.3%) had PVCs for the first time after successful revascularization, four of whom had previous myocardial infarction. The haemodynamic parameters of the total group during TET showed significant improvement in the duration of the exercise test (37%), the double product heart rate X systolic blood pressure (36%)M and the cardiorespiratory fitness (31%). Our data indicate that the ventricular ectopic activity induced by exercise in patients with coronary artery disease is not affected by successful revascularization. On the contrary, a significant number of patients develop new ventricular ectopy after CABGS where a pre-existing myocardial infarction appears to be a determining factor.

Adult↗
PubMed1978

Treatment of myocardial infarction in a community hospital coronary care unit. Experience with 1,246 patients.

The hospital mortality in 1,246 consecutive acute myocardial infarction patients treated in a large community hospital coronary care unit was 14.4%. Of the total, 52.3% showed no evidence of heart failure, 25.8% had mild to moderate failure, 9.9% had pulmonary edema, and 12% developed cardiogenic shock; the mortality in these groups was 2.2%, 7.4%, 8.9%, and 87.2%, respectively. The mortalitiy in the 1,097 patints who did not have cardiogenic shock was 4.5%. Only one patient died as a result of primary ventricular fibrillation (0.08%). The mortality of complete heart block in the absence of cardiogenic shock (8.3%) was not significantly different from that of comparable patients who did not have complete heart block (4.3%). These results are lower than those generally reported.

Acute Disease↗