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Biomedical subjects

A G Awad

Publications and source records attributed to A G Awad.

49 records · Page 3Linked to original sources
PubMed1985

Early treatment events and prediction of response to neuroleptics in schizophrenia.

Events that occur early in the course of neuroleptic drug therapy in schizophrenia and which may be useful in predicting clinical outcome were investigated. Early subjective response and symptom change at twenty-four and forty-eight hours following initiation of drug therapy with either CPZ or haloperidol were the only variables that significantly related to therapeutic outcome. These preliminary results replicate and confirm previous results and provide a tool which can be included with other available approaches in developing a battery for prediction of drug response.

Adolescent↗
PubMed1985

Early subjective response and prediction of outcome to neuroleptic drug therapy in schizophrenia.

Events that occur early in the course of neuroleptic treatment, and which may have utility in predicting short-term clinical outcome, were investigated. Such events include the patient's subjective response to drug, early clinical response, and the emergence of side effects. From all the variables examined, early subjective response and symptom change at 24 and 48 hours following initiation of neuroleptic drug therapy were found to be significantly related to short-term outcome. These findings are assessed with respect to their predictive utility and relative contribution to the development of a strategy for individualized drug treatment approaches in schizophrenia.

Antipsychotic Agents↗
PubMed1984

Diet and drug interactions in the treatment of mental illness--a review.

Drug-diet interactions in the treatment of mental illness are reviewed from two perspectives: the potential effects of drugs on a person's nutritional status, and the effect of diet on drug action through modification of its absorption or various stages of its metabolism. As mental illness is often chronic and recurrent, requiring long-term drug therapy, it is important to become aware of the effects of drugs and their possible interactions with other important factors such as food.

Antidepressive Agents, Tricyclic↗
PubMed1983

A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity.

Schizophrenic patients' self-reports of their experience of neuroleptic treatment were used as the basis for the construction of a scale predictive of drug compliance. Reliability analysis of the responses of 150 patients indicated high internal consistency in the 30-item scale, and preliminary validation in the form of discriminant classification accurately assigned 89% of the sample to complaint and non-compliant groupings. Both discriminant and factor analyses suggest that maximum variability in responding is accounted for by items reflecting how the patient feels on medication, rather than what he knows or believes about medication.

Adult↗
PubMed1983

Schizophrenia and multiple sclerosis.

A case of multiple sclerosis was diagnosed as paranoid schizophrenia 10 years earlier. The schizophrenic disorder, severe and almost nonremittent for 10 years, failed to respond to adequate drug therapy. The computerized axial tomography scan revealed moderate atrophy of the anterior cerebellar vermis, a finding of interest in view of studies which have implicated anterior vermis pathology in the pathogenesis of schizophrenia.

Adult↗
PubMed1983

Pharmacotherapy and suicide risk in schizophrenia.

The authors examined drug prescribing patterns and incidence of side effects in schizophrenic patients who committed suicide as compared with a matched control group. The groups did not differ in type of drug prescribed, though patients in the suicide group received significantly higher doses of fluphenazine enanthate. Extrapyramidal reactions occurred more frequently among the patients in the suicide group in the thirty days preceding suicide, and autonomic side effects less frequently, than in control patients for a corresponding period prior to discharge. The authors conclude that the probability of suicide is not related to the type of drug prescribed.

Adult↗
PubMed1981

Renal function in patients receiving long-term lithium therapy.

Renal function was assessed in 42 stable outpatients who had been taking lithium for an average of 4 1/2 years. Impaired ability to concentrate the urine was found in 61% of the 41 patients who provided a urine sample for an osmolality measurement, and a moderate reduction in creatinine clearance was present in 12% of the entire group; 1 patient showed both defects. Urine microscopy revealed an excess of cells in 40%. It is suggested that lithium therapy produces a self-limiting lesion of the distal nephron that does not usually progress to chronic renal failure. The lesion is not dangerous, except that it may predispose to acute neurotoxic effects in the event of intercurrent illness or dehydration.

Female↗
PubMed1980

Psychiatric audits. The Ontario scene.

Results of a survey conducted early in 1978, about the state of psychiatric audits in Ontario, are presented and discussed. Of the facilities that responded 66% reported the existence of an audit system for psychiatric care. The picture that evolves from the survey shows that audits are comprehensive in only 52% of Ontario facilities, more so in the provincial psychiatric hospitals than in psychiatric units in general hospitals. The audits are multidisciplinary in 64% of all facilities. While only 50% of facilities involved in audits felt that audits have a positive impact on improvement of psychiatric care, 71% were positive that audits have contributed to continuing staff education. The authors report their experience in introducing a criteria audit system. Factors influencing the selection, as well as advantages and criticisms of this model are discussed.

Cost-Benefit Analysis↗
PubMed1976

Urinary cyclic AMP in relation to lithium treatment in manic-depressive illness.

Urnary cyclic AMP was measured longitudinally in six patients with bipolar affective disorder. The values varied from 3.55 to 19.0 mugmol/24 hours with considerable variation between subjects. Three of these patients improved with administration of lithium carbonate. This improvement was not correlated with a change in cyclic AMP excretion. Five normal male volunteers were studied over a 5-day period. The urinary excretion for this group showed the same large intersubject variability but smaller intrasubject variation as was found for the patient group. It is suggested that erroneous results may be obtained for urinary cyclic AMP excretion if mean group values are used from patients not studied longitudinally.

Adult↗