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Biomedical subjects

A G Babaeva

Publications and source records attributed to A G Babaeva.

At least 19 recordsLinked to original sources
PubMed1993

[The phenomenon of the enhancement of the formation of lymphocytotoxic alloimmune antibodies during the use of plasmapheresis].

Apheresis was applied in 17 patients with hypoplastic anemia, myelodysplastic syndrome, chronic renal failure and other diseases sensitized to HLA. Apheresis was done for removal of anti-HLA antibodies and prevention of nonhemolytic transfusion reactions. Multiple massive apheresis led to a marked decrease in the antibody level. After the first or second apheresis with removal of 700.0-2000.0 ml of plasma weekly half of the patients showed increasing titres of lymphocytotoxic antibodies.

Antilymphocyte Serum↗
PubMed1991

[Suppression of epithelial cell proliferation in mice by splenocytes from unilaterally sialoadenectomized syngeneic donors].

Partially hepatectomized CBA mice immediately after the operation were intra-orbitally injected with splenocytes of intact (I), Sham-operated (SH-0) or unilaterally sialadenectomized (USAE) syngenic donors. It was shown that splenocytes from USAE donors in contrast to their types of splenocytes acutely suppress the mitotic activity of hepatocytes in the regenerating liver 48 and 72 h after their transfer. Splenocytes isolated 17, 144 and 168 h after removal of submandibular (together with sublingual) gland had the biggest inhibiting ability. Similar effect was obtained in respect of corneal epithelium due to administration of USAE mice splenocytes 17, 48 and 72 h after surgery. Operated recipients are more susceptible to the action of splenocytes from USAE donors, than the non-operated ones.

Animals↗
PubMed1991

[Variability of immune response in mice immunized at different time intervals after total or partial removal of organs with different reparative capacity].

The antibody response on sheep erythrocytes in the murine spleen at different time intervals after has been studied in one of the following operations: liver resection (70%), unilateral nephrectomy or sialadenectomy, or castration and bilateral sialadenectomy or castration. It was shown, that the liver and kidney surgery enhance the immune response if immunization was performed immediately or 24 h after the operation. Analogous changes of the immune response were observed under the immunization during 3 days after unilateral nephrectomy. The unilateral sialadenectomy evokes the contrary changes in immune response: immunization immediately or 24 h after the operation is accompanied by decrease of the above, the immunization on 3-7 days after the operation gets the increase of antibody genesis. Unilateral and bilateral castration as well as bilateral sialadenectomy evoke no changes of the immune response.

Animals↗
PubMed1990

[Lymphocyte-macrophage regulation of reparative erythropoiesis].

Experiments on mice have shown that the peritoneal cells and splenocytes transferred from anemic animals to normal syngenic recipients cause the appearance of signs of blood formation by the reserve erythropoiesis type, i.e. a decrease of the mitotic index in basophilic erythroblasts and appearance of mitotic oxyphilic erythroblasts. The capacity of peritoneal cells (PC) to transfer this type of the cell differentiation becomes manifest at 30 minutes, achieves its maximum at 2-4 hours, and becomes somewhat reduced at 48 hours after the blood loss. The transfer effect depends on the dose of introduced cells. The PC transfer capacity is higher than that of splenocytes. The lymphocyte inactivation by monoclonal anti-Thy-1,2 antibodies reduces the PC transfer capacity, which is indicative of the role played by the cell cooperation in promoting the transfer effect. Stimulation of erythropoiesis under the effect of macrophages and lymphocytes taken from anemic donors is significant and is accompanied by increased numbers of erythroid cells in the bone marrow and of reticulocytes in the peripheral blood.

Anemia↗
PubMed1990

[Lymphocytes as regulators of proliferation and differentiation of cells of non-lymphoid organs].

The morphogenetic function of lymphocytes was studied in their adoptive transfer from operated on donors to the syngeneic recipients (mice or rats). Splenocytes isolated at 2-17 h after extirpation of 2/3 of the liver, one kidney, or 1/2 of the small intestine were found to stimulate proliferation of cells in the recipient's organ homologous to the donor's. The morphogenic activity of splenocytes was directly proportional to the quantity of the removed organ tissue. Splenocytes isolated from the donor spleen after resection of 1/4 of the liver or 1/2 of a kidney showed no morphogenic activity. Splenocytes isolated at 36 h after resection of 2/3 of the liver at 48 h after resection of 1/2 of the spleen, or at 17 h after extirpation of one submandibular salivary gland inhibited proliferation of hepatocytes in the regenerating liver of the recipients. The stimulation effect was predominantly organ-specific, while the inhibition effect had no organ specificity. The involvement of lymphocytes (or lymphocytes with macrophages) in the regulation of cell differentiation was studied on a model after massive haemorrhage. The procedure was followed by a special type of erythropoiesis having distinct morphological markers and named the reserve erythropoiesis. It was demonstrated that the transfer of lymphoid cells and macrophages from anemized donors to normal recipients induced the development of signs of reserve erythropoiesis in the latter.

Animals↗
PubMed1985

[Effect of compensatory hypertrophy of the kidney on the ability of splenocytes to induce a regional graft versus host reaction].

The ability of C57BL/6 mouse splenocytes to induce regional GVHR during uni- and bilateral nephrectomy, ligation of the ureter and sham operations was studied. It was shown that any kidney operation enhances the ability of splenocytes to induce the GVHR in contrast to uni- and bilateral sham operations. This phenomenon was first observed during bilateral nephrectomy (after 5 h), unilateral nephrectomy (after 24 h) and ligation of the ureter (after 72 h). The data indicate that deficiency of the tissue is the main cause of changes in the immunity system status rather than changes in antigen properties and functional insufficiency of the kidneys.

Animals↗
PubMed1984

[Dynamics of the activity of the normal mouse spleen killers after partial splenectomy].

The activity of natural killers from the mouse spleen was determined by 51Cr clearance from labeled target cells (YAC-1) at different times after resection of the two-thirds of the spleen. In the early periods after operation, there was a decrease in the natural cytotoxic activity of splenocytes followed by a relatively rapid rise for 8 days until the maximum exceeding the cytotoxicity of intact spleen cells was reached. However, the total lytic potential of the regenerating spleen did not return to normal during 28 days.

Animals↗
PubMed1984

[Appearance of the signs of stress in mice as affected by lymphoid cells from syngeneic hypokinetic animals].

Lymphoid cells of the spleen were transferred from F1(CBA X C57BL/6) mice exposed to hypokinesia for 17 hours to unoperated and partially hepatectomized syngeneic recipients. It caused (on days 2, 3 and 7) changes in the body weight, thymus, spleen, adrenals and in proliferative activity of hepatocytes in the intact and regenerating liver, with these changes being similar to those induced by stress alone.

Animals↗