Biomedical subjects

A G Baikie

Publications and source records attributed to A G Baikie.

At least 19 recordsLinked to original sources

PubMed1980

Clinical findings in patients with numerical abnormalities of the X chromosome: a three-year survey of consecutive admissions to a general hospital.

A buccal smear study of 21,634 consecutive patients admitted to a general hospital was carried out over a period of three years. Twenty-eight patients were found to have an X-chromosome abnormality giving an over-all frequency of 1.3 per 1000. There were 19 males with Klinefelter's syndrome and nine females with triple-X syndrome. The sex chromosome abnormality had been diagnosed in only one patient before this study began, but examination after admission to hospital showed that the presence of small testes was an invariable finding in the postpubertal males with Klinefelter's syndrome. No other feature was found which could be considered diagnostic of an X-chromosome abnormality. The frequency of Klinefelter's and triple-X syndromes in this hospital population did not differ from the recorded frequency of these syndromes at birth.

Adolescent↗

PubMed1977

An assessment of hostility in a population of adolescents.

In the course of an epidemiological survey of adolescents, the Hostility and Direction of Hostility Questionnaire was administered to 6,709 persons aged 13 to 18 years, representing 89% of secondary school students in Hobart, Tasmania. Extrapunitiveness was found to decrease substantially between the ages of 15 and 17 years in both sexes. Intropunitiveness also decreased, although to a lesser extent. Girls were less extrapunitive and more intropunitive than boys over the whole age range. These findings are discussed in relation to their clinical relevance and to the understanding of psychiatric disorder in adolescents.

Acting Out↗

PubMed1977

Lymphoproliferative and myeloproliferative disease in Tasmania.

Tasmania, an island state of the Australian Commonwealth with a population of 400,000 of predominantly Anglo-Saxon heritage, has relatively centralized oncology services. A study was undertaken of all patients known in December 1971 and of all new cases diagnosed since January 1972 with all forms of leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, myeloma, and other myeloproliferative and lymphoproliferative disorders. Data were obtained with respect to lifetime residential and occupational history, schools attended, and known familial cases of any of the myeloproliferative and lymphoproliferative disorders.

Australia↗

PubMed1975

Splenectomy for complications of chronic granulocytic leukaemia.

13 patients with chronic granulocytic leukaemia (C.G.L.) which was unsatisfactorily controlled underwent splenectomy. 3 out of 4 patients with hypersplenism did well, as did 5 out of 8 patients in whom the C.G.L. had undergone metamorphosis to a refractory phase. In a case of C.G.L. complicated by severe myelofibrosis the need for transfusion was reduced but survival was short. Splenectomy should be considered when C.G.L. in its chronic phase is complicated by hypersplenism, and may be considered as a part of the treatment after C.G.L. has undergone metamorphosis to a refractory phase. However, a favourable outcome is unlikely for patients over 65 years, and in the presence of coexistent illnesses, rapidly progressive metamorphosis to an acute phase, or severe bone-marrow failure from any cause. In C.G.L., elective splenectomy early in the chronic phase must be clearly distinguished from splenectomy performed at a later stage when the disease is not well controlled.

Adolescent↗

PubMed1975

Carl de Gruchy.

Explore the source record for details and available documents.

Australia↗

PubMed1975

Neutrophil alkaline phosphatase score in chronic granulocytic leukaemia: effects of splenectomy and antileukaemic drugs.

Staining with naphthol AS phosphate and Fast Blue BB salt has been used for the estimation of neutrophil alkaline phosphatase (NAP) scores in patients with chronic granulocytic leukaemia (CGL). The very low scores found at diagnosis rise when the disease is treated, and there is some inverse correlation between the NAP score and the absolute neutrophil count. Patients treated intensively developed high NAP scores. Elective splenectomy performed during the chronic phase of CGL is followed by a pronounced but transient neutrophilia and a concurrent striking rise in the NAP score. Similar changes were observed in patients without CGL who underwent splenectomy. These observations can be explained by assuming that newly formed neutrophils in CGL have a normal content of NAP but are rapidly sequestered in non-circulating extramedullary pools, whereas the circulating neutrophil with a typically low NAP content is a relatively aged cell which has lost enzyme activity. In subjects with or without CGL, removal of the spleen, a major site of such pooling, temporarily permits the circulation of newly formed neutrophils but eventually other organs assume the sequestering functions of the spleen. Thus the aberrations of NAP score seen in CGL might be attributable not to an intrinsic cellular defect but to an exaggeration of the granulocyte storage phenomena which also occur in subjects without CGL.

Alkaline Phosphatase↗

PubMed1974