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Drug Industry↗
Biomedical subjects
A G Benbow
Publications and source records attributed to A G Benbow.
Mesalazine preparations.
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Anti-Inflammatory Agents, Non-Steroidal↗
Patient compliance with inhaled medication: does combining beta-agonists with corticosteroids improve compliance?
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Administration, Inhalation↗
The immunopharmacological actions of nedocromil sodium relative to the use of its 2% ophthalmic solution.
The immunopharmacological actions of nedocromil sodium are fully compatible with administration to man. Nedocromil sodium exhibits a wide range of anti-inflammatory actions. When compared with sodium cromoglycate, nedocromil sodium is more potent and a major difference is seen in the Ascaris-sensitised monkey subjected to bronchial challenge with specific antigen. In this model of chronic airway disease nedocromil sodium provides significant protection against changes in airway resistance and lung compliance provoked by antigen challenge. Sodium cromoglycate does not. This difference is most readily explicable by the greatly enhanced effect of nedocromil sodium, relative to that of sodium cromoglycate, in preventing the release of mediators such as histamine, leukotriene C4 and prostaglandin D2 from the cellular population of the chronically inflamed bronchus, especially from mast cells of the mucosal type. There is growing evidence that these mediators are important in allergic diseases of the eye and this additional activity may be expected to give nedocromil sodium extended scope in the management of conjunctivitis in which allergic inflammation and hyperresponsiveness are significant pathophysiological factors.
Animals↗
Acute rheumatic fever in human immunodeficiency virus infection.
A 25-year-old homosexual man with a childhood history of rheumatic heart disease presented with painful joints, fever and chest pain. He was diagnosed as having acute rheumatic fever and was found to be HIV antibody-positive. His illness responded to conventional treatment but he had a persistently low CD4 lymphocyte count and was started on zidovudine. Interpretation of the significance of a low CD4 lymphocyte count is problematic in a patient with coincident rheumatic fever and HIV infection as both conditions can cause CD4 lymphopenia.
Acute Disease↗
Pulmonary hypertension in hydralazine induced systemic lupus erythematosus: association with C4 null allele.
A patient who developed pulmonary hypertension and systemic lupus erythematosus as a complication of hydralazine therapy is reported. She was a slow acetylator and in addition was found to have a null allele at the C4A locus.
Alleles↗
"Monitors" and EC guidelines.
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Clinical Trials as Topic↗