PubMed Health⌕ Search

Biomedical subjects

A G DeVoe

Publications and source records attributed to A G DeVoe.

17 recordsLinked to original sources
PubMed1979

Giant papillary conjunctivitis with ocular prostheses.

In seven patients who each had either a methyl methacrylate corneal shell, a postenucleation ocular prosthesis, or a keratoprosthesis, giant papillary conjunctivitis of the tarsus of the upper lids developed after prolonged wear. These cases expand the spectrum of disease that was initally described in wearers of hard and soft contact lenses. The papillary changes in prostheses wearers did not always produce symptoms and were not readily reversible. Basophils and mast cells characterized the inflammatory infiltrate, suggestng an antigen-antibody mechanism underlying the response. Increased production of epithelial mucin, in contrast to goblet cell mucin, may play a role in producing symptoms in this syndrome.

Adolescent↗
PubMed1979

Vitreous wick syndrome.

A 67-year-old man had vitreous wick syndrome after an uncomplicated intracapsular cataract extraction with a sector iridectomy in the left eye. The intraocular infection cleared with antibiotic therapy including intravitreal antibiotic injection, but a residual anterior cyclitic membrane and shallow anterior chamber persisted. An anterior vitrectomy was performed later in the course of treatment after the intraocular infection subsided, to relieve the shallow anterior chamber, prolonged hypotony, and ciliary body detachment. Final visual acuity was 6/15+(20/50+) in the left eye.

Aged↗
PubMed1978

Epibulbar mucogenic subconjunctival cysts.

Two patients had freely movable epibulbar subconjunctival cysts that occurred in the absence of trauma, inflammation, and infection. Histopathologic examination of these cysts revealed them to be linked by nonkeratinizing epithelial cells and goblet cells. The cysts had little or no stroma and contained PAS-positive mucoid material. Electron microscopy of adjacent conjunctiva indicated that the epithelial cells were actively producing mucous granules and did not form many hemidesmosomes. The mechanical displacement of epithelial cells, as well as their mucous-producing ability, probably contribute to cyst formation. The relative lack of hemidesmosomes may explain why these cysts are freely movable.

Aged↗
PubMed1977

Fibrous histiocytoma of the tarsus.

A 21-year-old white man had an asymptomatic eyelid mass that had slowly enlarged for one year. On clinical examination the lesion was well circumscribed; it appeared subconjunctivally but provoked no conjunctival inflammation, and had a consistency suggestive of cartilage. Microscopic examination showed it was matted and composed of elongated fibro-histiocytes and an evenly distributed population of xanthoma cells and Touton giant cells. The lesion was easily removed by local excision because of a pseudocapsule formed by remnants of the tarsus; there has been no recurrence during a 12-month follow-up.

Adult↗
PubMed1977

Electron microscopy of epithelial downgrowth.

Four cases of epithelial downgrowth following cataract surgery were studied by electron microscopy. The invading epithelium was excised by posterior keratectomy, iridectomy, and vitrectomy. Diagnostic photocoagulation on the iris was performed before the operations in all cases. Multilayered epithelium on these tissues showed ultrastructural features similar to conjunctival epithelium, and in the cornea no intact endothelial cells were identified. A subepithelial connective tissue of varying grades of development was present between the downgrowth epithelium and Descemet's membrane. The basal epithelial cells on the vitreous contained numerous dense granules, and a thick basement membrane-like layer was found underneath. Changes attributable to photocoagulation included partial replacement of the iris pigment epithelium with macrophages, degeneration of blood vessels, and marked swelling and dissociation of collagen fibrils in the iris stroma due to splitting into longitudinal filamentous components. Identical changes of collagen fibrils could be reproduced in the rabbits iris after experimental photocoagulation.

Aged↗
PubMed1976

Electron microscopical study of the Fleisher ring.

The Fleischer ring of keratoconus was studied with the transmission electron microscope in four corneal buttons. The ring was characterized by accumulations of ferritin particles in the widened intercellular spaces and/or in the cytoplasmic vacuoles of the corneal epithelium. Both changes were prominent in basal layers in three cases; in one case, ferritin-containing vacuoles were noted in wing cell layers. Ferritin particles were also scattered over the corneal epithelium in all cases. For comparison, normal human corneas and conjunctivas were studied. Ferritin particles were scattered over the corneal epithelium and throughout the basal cells of the conjunctiva. They were not found in corneal stroma or endothelium. In conjunctival stroma, numerous ferritin particles were observed in the cytoplasm of some macrophages. Possible origin of these particles and the cause of their deposition are discussed.

Conjunctiva↗
PubMed1975

Ultrastructural variation in granular dystrophy of the cornea.

Corneal deposits of granular dystrophy were studies in six corneas from five patients. Two additional corneas from two patients with lattice dystrophy were used for comparison. The diagnoses were confirmed by light and electron microscopy. Three types of ultrastructural features were distinguished in the electron-dense rod-shaped deposits of granular dystrophy, i.e., Type 1 with homogenous structure, Type 2 with fibrillar constituents, and Type 3 with a moth-eaten or sponge-like appearance. In polarization microscopy of Congo-red stained sections, the Type 2 tended to show an increased birefringence without green dichroism, while the other types were less birefringent than the stroma. Three different components were found immediately around the deposits, i.e., 1. normal collagen fibrils, 2. finely filamentous substance, and 3. areas of thin fibrils (70-100 A in diameter). While the second component appeared non-specific, the third component was found only in two corneas, superimposed on the lesions of granular dystrophy, and showed light and electron microscopic characteristics of the lesions of amyloid as well as of lattice dystrophy.

Aged↗
PubMed1975

Recurrent granular corneal dystrophy.

Four full-thickness corneal buttons and tissue from one lamellar keratoplasty, derived from four patients with granular corneal dystrophy recurring in previously transplanted corneas, were studied by light and transmission electron microscopy. Fibrous tissue without vascularization was present between the epithelium and Bowman's membrane and contained deposits characteristic of granular dystrophy in both light and electron microscopy. The recurrence of dystrophy in the normal donor cornea is the result of infiltration of the grafted cornea by host invasion. The donor stroma is spared.

Adolescent↗
PubMed1975

Kaposi's sarcoma of the conjunctiva.

A 75-year-old man with known Kaposi's sarcoma of three-years' duration developed chronic hemorrhagic thickening of the conjunctiva. Biopsy demonstrated histopathologically that the conjunctiva thickening represented sarcoma involvement. Although surgically untenable, the conjunctival lesion responds satisfactorily to radiotherapy.

Aged↗
PubMed1975

Complications of keratoplasty.

The complications of keratoplasty have been greatly reduced in recent years by virtue of finer instrumentation, microsurgery, new drugs to minimize postoperative complications, and improved methods of donor cornea preversation. A 49-year-old woman, following uncomplicated keratoplasty with donor material from a patient who had died of a slow virus disease, developed the same condition and died 18 months later. Until more evidence is available, donor material from individuals dying of obscure chronic central nervous system disorders should be used with extreme caution.

Autopsy↗