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Biomedical subjects

A G Dudley

Publications and source records attributed to A G Dudley.

At least 19 recordsLinked to original sources
PubMed1992

Primary fallopian tube carcinoma with coexistent tuberculous salpingitis: a case report.

A case of primary carcinoma of the fallopian tube with coexistent tuberculosis has been presented, and previously reported cases in the literature reviewed. These cases represent a rare occurrence where the diagnosis might be missed without a thorough pathologic evaluation. Clinicians should maintain an index of suspicion for fallopian tube carcinoma in perimenopausal or postmenopausal women with menometrorrhagia who fail to respond to hormonal therapy and a D and C. The finding of a tuboovarian abscess in a postmenopausal woman should also cause concern for tubal carcinoma, as it is usually a disease of menarcheal women. Similarly, a possibility of granulomatous salpingitis should always be borne in mind in the differential diagnosis of inflammatory diseases of the fallopian tube.

Adenocarcinoma↗
PubMed1991

The Sister (Mary) Joseph nodule: its significance in gynecology.

Twenty-five cases of metastatic carcinoma of the umbilicus in women diagnosed and treated at Emory University Hospitals from 1973 to 1989 were reviewed, as were all previously reported cases in the English language literature. In our series, overall survival was greatest in patients treated with aggressive surgery and chemotherapy, compared with patients receiving no therapy or those treated with either surgery or adjunctive therapy alone. Individual survival was enhanced when the primary tumor site was of ovarian origin.

Abdominal Neoplasms↗
PubMed1990

Adhesion formation after ovarian wound repair in New Zealand white rabbits: a comparison of ovarian microsurgical closure with ovarian nonclosure.

Thirty female New Zealand white rabbits underwent standard laparotomy. Each ovary was bivalved and hemostasis was achieved with bipolar electrocautery. One ovary was then randomized to the closure group, whereas the other ovary was placed in the nonclosure group. In the closure group, the ovarian capsule was closed with a continuous suture of 8-0 Vicryl absorbable surgical suture material with microsurgical technique. In the nonclosure group, the ovaries were left open. Three weeks later the animals were killed and the ovarian adhesions were graded with a standardized scale by an observer (A. A. T.) blinded to the closure status of the animals. Five control animals underwent sham operations with minimal adhesion formation. Statistical analysis of the study animals by the paired Student t test showed a significantly higher adhesion score on the ovaries that were microsurgically closed compared with the ovaries not closed (p = 0.02).

Animals↗
PubMed1990

Amniotic membranes in the treatment of necrotizing fasciitis complicating vulvar herpes virus infection.

Necrotizing fasciitis of the vulva developed in an immunocompromised patient with chronic myelogenous leukemia, apparently from secondarily infected herpes simplex lesions. In addition to surgical debridements and broad-spectrum intravenous antibiotic therapy, the wound was treated using specially prepared amniotic membranes as a wound dressing. The patient died on hospital day 65 because of complications of her immunocompromised state, with autopsy findings of disseminated cytomegalovirus. However, use of amniotic membranes as a wound dressing appeared to be beneficial.

Adult↗
PubMed1984

Granulosa cell, Sertoli-Leydig cell, and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases.

Seventeen granulosa cell, thirteen Sertoli-Leydig cell and six unclassified sex cord-stromal tumors diagnosed during pregnancy or the puerperium were reviewed. Eleven patients presented with abdominal pain or swelling, five in shock, two with virilization, and one with vaginal bleeding. Three asymptomatic patients were explored because of a palpable mass and one because of an adnexal mass found on ultrasound examination. In thirteen patients the tumor was discovered during a cesarean section; five of them had had dystocia and in eight of them the tumor was an incidental finding. All the tumors were Stage I but 13 of them had ruptured; all but one were unilateral. Hemoperitoneum was present in seven cases. On microscopical examination many of the tumors differed from tumors in the same diagnostic categories occurring in the absence of pregnancy by having a disorderly arrangement of their cells, lacking recognizable differentiation in many areas, showing prominent edema, and containing unusually large numbers of lutein or Leydig cells. The last two features were most obtrusive in tumors removed at term. With one exception the patients were initially treated by conservative surgical procedures. Two of them received chemotherapy and two radiation therapy postoperatively. A hysterectomy and salpingo-oophorectomy was performed at a second operation in eight cases; no residual tumor was found in any of the specimens. Only one patient had a recurrence, which was treated surgically. Follow-up for an average of 4.7 years is available for 30 of the 36 patients; all of them were alive and free of disease at the time of the last examination.

Adolescent↗
PubMed1983

Endodermal sinus tumor of the vulva in an infant.

An endodermal sinus tumor arising in the vulva of a 22-month-old infant is reported and the features of 3 previously recorded endodermal sinus tumors of the vulva are reviewed. Despite radical surgery, radiation therapy, and chemotherapy the tumor was fatal within 6 months. Only one of the 3 previously described patients with this type of vulvar tumor has survived more than 2 years. That tumor was the smallest reported, being the only one under 2 cm in diameter.

Biopsy↗
PubMed1982

Hepatocellular carcinoma associated with oral contraceptive use and pregnancy.

Numerous undesirable side effects have been attributed to oral contraception, from mild breast discomfort to thromboembolism. The authors present a case report of hepatocellular carcinoma associated with oral contraceptive use and pregnancy and discuss the potentially fatal association of malignant liver tumors with usage of oral contraception.

Adult↗
PubMed1979

Delayed traumatic rupture of the diaphragm in pregnancy.

Traumatic rupture of the diaphragm may result from trauma or from direct penetrating injuries. The rupture is often an occult injury, which can have a symptom-free interval that may last for years. This paper presents the first 2 reported cases of delayed rupture associated with intrauterine pregnancy. A review of clinical signs and symptoms is presented along with typical radiological findings. Mortality in the nonpregnant state approaches 50% and varies directly with the number of organs involved, the presence of strangulation, and the interval of time from rupture to surgical intervention. The authors conclude that all obstetrical patients with a history of penetrating wounds of the chest or upper abdomen require special evaluation and prompt surgical intervention if delayed rupture of the diaphragm is established.

Adolescent↗
PubMed1976

Infiltrating ductal carcinoma of the breast in the postpubertal adolescent: a case report.

Infiltrating ductal carcinoma is an extremely rare neoplasm in the teenage or pre-teenage child. Routine pediatric physical examination should include careful examination of the breast and all palpable masses should be excised. Carcinoma occurring in the prepubertal child carries an improved prognosis particularly if the tumor stains PAS-positive. Carcinoma occurring in the postpubertal teenager probably carries the same prognosis as that in the adult and should be treated in a similar manner. The authors discuss such a case occurring in a 13-year-old girl.

Adolescent↗