PubMed Health⌕ Search

Biomedical subjects

A G Hocken

Publications and source records attributed to A G Hocken.

At least 19 recordsLinked to original sources
PubMed1987

Citrate regional anticoagulation in haemodialysis.

The use of citrate as an anticoagulant in haemodialysis is for patients who are recognised to be at risk if systemically anticoagulated. This paper describes a trial of use of a technically simple procedure involving the use of small volumes of citrate solution. It introduces the measurement of plasma citrate levels in a population of stable patients on regular dialysis treatment. Using synchronous pre- and post-dialyser blood samples, measurement of the whole blood clotting times demonstrated the restriction of anticoagulation to the extracorporeal circulation. It is concluded that citrate anticoagulation is safe, acceptable and simple for use in haemodialysis for patients at risk from systemic anticoagulation.

Anticoagulants↗
PubMed1986

Microalbuminuria in a diabetic population.

The aim of the report is to define that diabetic population which is to be recognised as at imminent, and possibly reversible, risk of diabetic nephropathy. The prevalence of 0.63% of diabetes in the Mosgiel practice population is confirmed. Of the 84 diabetics studied eight (9.5%) had proteinuria and an additional nine (10.7%) had microalbuminuria. The means of quantification of microalbuminuria as the urinary albumin/creatinine ratio has been documented for a New Zealand population.

Aged↗
PubMed1985

Renal calcium conservation in recurrent stone-formers with idiopathic hypercalciuria.

Urinary excretions of calcium and cyclic AMP were studied in male recurrent stone-formers after an overnight fast and following an oral calcium load. The results from eight patients with established hypercalciuria (greater than 7.5 mmol Ca/24 h) were compared with those from eight age matched normocalciuric stone-formers. The urinary calcium/creatinine ratio was higher in the hypercalciuric group both when fasting and calcium loaded whilst their urinary cyclic AMP was lower in both 24-h and calcium-loaded collections. Five of the eight hypercalciuric patients exhibited an increased urinary calcium/creatinine ratio whilst fasting. These findings support the view that renal calcium wasting, in association with suppression of parathyroid activity, is common among men with idiopathic hypercalciuria. Dietary calcium restriction may lead to bone loss in patients with obligatory renal calcium wasting and enteric adsorption is rarely applicable to the treatment of stone disease. Therefore, the demonstration of a high fasting urinary calcium/creatinine ratio is a strong indication for therapeutic agents which act to suppress renal calcium loss to treat hypercalciuria.

Adult↗
PubMed1984

Dialysis encephalopathy associated with polyvalent ion contamination.

The histories of five long term dialysis patients, all of whom showed the characteristic features of dialysis bone disease are considered. One population, on hospital dialysis, also suffered dialysis encephalopathy, whilst the home dialysis population did not. It is postulated that the excessive polyvalent ion content of the water supply to a new hospital building displaced aluminum from the bone stores and precipitated encephalopathy in three patients over three months. The relationship of bone lysis (corticosteroids, immobilisation and orthopaedic procedures) to encephalopathy is considered in the light of this experience.

Adult↗
PubMed1983

Urine oxalate levels in a New Zealand reference population and renal stone formers.

Increasing attention is being given to oxalate as a risk factor in urinary calcium stone disease. The accuracy of some methods for measuring urine oxalate is uncertain. Using gas chromatography urine oxalate levels were 0.36 +/- 0.02 and 0.31 +/- 0.02 (mmol/24 h +/- 1 SEM) for men and women respectively of a reference population. In recurrent stone formers urinary oxalate was 0.43 +/- 0.03 in males and 0.38 +/- 0.04 for females whilst solitary stone forming females excreted only 0.31 +/- 0.04 mmol/24 h. The difference between males and females of the reference population was significant (p less than 0.05) as was the difference between reference males and male stone formers.

Adolescent↗
PubMed1982

Haemolysis in chronic renal failure.

In a group of patients with a range of degree of advancement of renal failure, the red cell survival estimated as the half-life of radiochromium-labelled red blood cells (T1/2. 51Cr) was correlated with several indices of renal failure. The T1/2. 51Cr was not improved by a dialysis programme which was otherwise adequate. Furthermore, the correlation of a T1/2. 51Cr to the biochemical indices of renal failure was lost which might suggest that some other factor or factors than those measured was the ultimate correlate with red cell survival. This work adds to the circumstantial evidence in favour of a guanidine or a similarly behaving molecule being the haemolyzing agent. The additional premise is extended that a methionine-rich diet will inhibit the haemolytic factor.

Erythrocyte Aging↗
PubMed1980

Proteinuria in an Otago diabetic population.

A prospective examination was conducted of a five man group practice in Mosgiel, Otago. The incidence of diabetes was ascertained, and the frequency of proteinuria in that diabetic population. Thirteen percent of those examined showed proteinuria. Proteinuria appeared best related to the presence of retinopathy, and the known duration of the diabetes.

Diabetes Complications↗
PubMed1979

A comparison of des-amino arginine vasopressin with pitressin tannate as diagnostic agents.

A reappraisal of a previous opinion, and subsequent comparative work leads to the conclusion that 40 microgram desamino arginine vasopressin (DDAVP) administered instransally, is a preferable dose to 20 microgram to use as a urinary concentrating agent in the diagnostic context, and that it is quite comparable to the standard agent, five units of pitressin tannate in oil.

Arginine Vasopressin↗