Biomedical subjects
Publications and source records attributed to A G Logvinenko.
A simple method for measuring the relative content of human blood oxyhemoglobin is suggested, not involving the use of toxic reagents. The calculation is made from a newly derived third-degree polynomial reflecting the ratio of the optic densities of whole nonstabilized blood hemoglobin aqueous solution in the 560-580 and 535-560 nm bands.
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Kinetics of changes in absorption spectra (240-650 nm) of aqueous extracts from bloodstains of considerable age (11 years) was studied. It was stated that at early storage time modification of globin residue goes parallel to oxidation of haem residue and at continuous time (more than 1 year) of solid phase storage of blood films considerable damage of protein and haem with their subsequent destruction occurs. But intensity of these processes is likely to depend on factors of initial environmental exposure of fresh bloodstains.
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The circadian pattern of hemocoagulation was studied in patients with decompensated rheumatic heart disease (DRHD) concurrent with stages I-II circulatory failure (CF) during complex treatment or medical treatment with disaggregants. Biorhythmological studies demonstrated that in patients with DRHD and CF chronotherapy with curantyl had some advantages over the traditional therapy during complex drug therapy. In these patients, the chronopatterns of circadian rhythms of hemocoagulative parameters tended to normalize under the influence of curantyl chronotherapy, by diminishing the signs of external desynchronization. Advantages of chronotherapy over the traditional treatment found in patients with DRHD and stages I-II CF, as manifested by its clinical effect in shorter periods (on days 4-5) when small daily and course doses of the drug were used. Based on the biorhythmological studies of hemostatic parameters, a method of curantyl chronotherapy was developed for patients with DRHD and stages I-II CF, which may optimize the therapeutical process in patients with this abnormality.