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Biomedical subjects

A G Olsen

Publications and source records attributed to A G Olsen.

5 recordsLinked to original sources
PubMed1994

The influence of ambient salinity and temperature on lipid metabolism in toad (Bufo bufo) skin. Is phosphatidylethanolamine an endogenous regulator of ion channels?

Incorporation of (32P) phosphate and (14C) acetate into frog (Rana temporaria) skin phospholipids in vitro was positively correlated to skin MR cell density. Transport across toad (Bufo bufo) skin and incorporation into skin phospholipids of the radioactive tracers were independent of transepithelial electrical potential in vitro. While all the incorporations in vitro showed (32P) and (14C) frog and toad skin phospholipid patterns dominated by phosphatidylcholine-independent of adaptational temperature and salinity--corresponding phospholipid patterns dominated by phosphatidylethanolamine (PE) were found in vivo, when toads adapted to Ringer solution were transferred to tap water containing tracer amounts of (32P) phosphate and (14C) acetate. PE could play a role in the formation of a "hydrophilic" environment and thereby, e.g. stabilise the integral membrane proteins that regulate the function of ion channels.

Animals↗
PubMed1991

Rewarding overproductivity: an incentive or disincentive for staff?

A rapidly growing home care agency implemented a productivity system designed to reward its staff for "overproductive" visits rather than rely on temporary staff. While the system was positively received, it actually became more of a disincentive than a motivator.

Community Health Nursing↗
PubMedDate not supplied

Topical therapy for peristomal pyoderma gangrenosum.

BACKGROUND: Pyoderma gangrenosum (PG) is an uncommon condition. Literature on the management of peristomal PG (PPG) is sparse. In the absence of randomized controlled trials the reporting of case series is potentially helpful to the management of this uncommon disease. OBJECTIVE: In this study we report our experience with topical corticosteroid therapy for 14 consecutive cases of PPG. METHODS: A clinical diagnosis PPG was made by a trained dermatologist using the appropriate investigations where necessary. RESULTS: The majority of the cases presented were managed with simple topical corticosteroids, occasionally in combination with a change of dressing. In 8/14 (57%) cases ulcer resolution was achieved within 3 months with topical treatment alone or topical treatment plus a change of dressing to a silicone-based product applied directly to the wound under the normal base plate of the stoma bag. CONCLUSION: Our experience suggests that a significant proportion of PPG can be managed by topical treatment alone. The simple topical treatment allows the patient to continue use of stoma care products while minimizing the potential for side effects.

Adult↗
PubMedDate not supplied

Study of peristomal skin disorders in patients with permanent stomas.

The aim of this article was to investigate the frequency, severity and diversity of peristomal skin disorders among individuals with a permanent stoma in a community population. All individuals with a permanent stoma (n=630) in a Danish community population were invited to participate in a cross-sectional study. A total of 202 individuals (101 men; 101 women) agreed to participate. Data were collected through questionnaires and clinical examinations. It was found that peristomal skin disorders were higher for participants with an ileostomy (57%) and urostomy (48%) than in those with a colostomy (35%). Of the diagnoses of skin disorders, 77% could be related to contact with stoma effluent. Only 38% of diagnosed participants agreed that they had a skin disorder and more than 80% did not seek professional health care. The study revealed a high frequency of peristomal skin disorders. Participants frequently failed to perceive that they had a skin irritation and did not seek help. This suggests that more education and perhaps regular, annual follow-up visits at local stoma care clinics are needed.

Adolescent↗