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Biomedical subjects

A G Pullinger

Publications and source records attributed to A G Pullinger.

At least 19 recordsLinked to original sources
PubMed1996

A multiple stepwise logistic regression analysis of trauma history and 16 other history and dental cofactors in females with temporomandibular disorders.

The simultaneous contribution of 11 occlusal factors, dental attrition severity, orthodontic history, trauma (motor vehicle accident [MVA] and non-MVA), and age in defining two independent large populations of females diagnosed with five mutually exclusive temporomandibular disorders was tested through multiple stepwise logistic regression analysis. Non-MVA trauma was significant in both groups in defining disc displacement (DD) with and without reduction, and osteoarthrosis (OA) (both primary and following DD). Anterior open bite was also a significant factor in defining OA in both groups. Much smaller contributions were also made by missing teeth in one of the populations with OA following DD, and by retruded contact position-intercuspal position slide lengths and overjet in one of the primary OA populations. Motor vehicle accident trauma was significant in defining myofascial pain (MP) in both populations, and laterotrusive attrition mildly defined MP in one population. Only a minority of total variance was explained: 6% to 8% of DD with reduction; 10% to 14% of DD without reduction; 11% to 20% of OA following DD; 17% to 38% of primary OA; and 4% to 10% of MP. Non-MVA trauma was the major defining feature of the temporomandibular joint intracapsular disorders, and MVA trauma explained a very small percentage of the MP patients. Implications are discussed and recommendations are made for future research.

Adolescent↗
PubMed1995

Efficacy of TMJ radiographs in terms of expected versus actual findings.

OBJECTIVES: The purpose of this study was to measure the amount of new information contributed by temporomandibular joint tomograms beyond that anticipated by the patient's clinical presentation. STUDY DESIGN: The results of a clinical examination and history, including a video of patient interview, and dental casts of 105 patients with a temporomandibular disorder were presented to a panel of general dentist evaluators with some experience in temporomandibular disorders. These evaluators then described the radiographic findings they anticipated. Lastly they examined temporomandibular joint tomograms for each of the study patients and scored their findings. RESULTS: The temporomandibular joint tomograms revealed unanticipated osseous changes in 61% of case judgments of condyles and 47% for the temporal bone or 34% and 22%, respectively, when subtle changes were excluded. Unexpected condyle positional findings were revealed in 31% of the patients. When stratified by clinical class, osteoarthritis and internal derangement, false-positive and false-negative interpretations were 12.1% and 25.5%, respectively, for osteoarthritis, and 12.2% and 17.3% for derangement. CONCLUSIONS: The fairly high rate of unexpected new osseous and positional findings supports the need for tomograms in patients with a clinical diagnosis of derangement or osteoarthritis.

Facial Pain↗
PubMed1995

Impact of TMJ radiographs on clinician decision making.

OBJECTIVES: This study examined the influence of lateral and frontal temporomandibular joint tomograms on the initial diagnosis and treatment plan of patients having facial or preauricular pain or temporomandibular joint disorders. STUDY DESIGN: Five or six general dentists, all with experience in treating patients with disorders of the temporOmandibular joint, examined records of 105 patients from a university-based orofacial pain clinic. The examiners proposed a diagnosis and treatment plan for each patient without the benefit of tomograms. They then repeated this procedure after study of the radiographs. The impact of the radiographs was measured as the change in pre- versus postradiographic diagnosis and treatment plan. RESULTS: The availability of temporomandibular joint tomograms changed or modified diagnosis in 65% of the judgments and influenced treatment recommendations in 40%. These changes were substantive for 21% of the diagnoses and 22% of the treatment plans. The strongest correlation to changes in both diagnosis and treatment plan was with radiographic detection of osseous changes. New information about condyle position had less effect on clinical decisions. CONCLUSIONS: These findings indicate that temporomandibular joint tomograms play a valuable role in influencing clinician's diagnosis and treatment plan of patients with disorders of the temporomandibular joint.

Decision Support Techniques↗
PubMed1995

The degree to which dental attrition in modern society is a function of age and of canine contact.

Dental attrition ranked according to a validated severity scale correlated with age as a proxy for functional wear in 148 asymptomatic subjects. Anterior, posterior, mediotrusive, laterotrusive, and total attrition severity was analyzed. The geometric contribution of canine attrition to the variance of posterior attrition was also tested through correlations, and the time span required to record a statistically significant difference in attrition using the scale was determined. Age explained 12.6% of the differences the total attrition scores (P < .001, Spearman's rho), 6.4% of the anterior scores (P < .01), and 20.9% of the laterotrusive scores (P < .0001). Canine wear in subjects aged 20 to 49 years explained between 20% to 34% of the posterior attrition (P < .05 to P < .001), 6% to 36% of the mediotrusive attrition (P < .05 to P < .01), and 20% to 29% of the laterotrusive attrition (P < .05 to P < .001). At least 20 to 30 years was necessary to show significant clinical differences, except that laterotrusive attrition changes could be discriminated in only 10 years for the 20- to 29-year-old group. Notable attrition was already evident in the 20- to 29-year-olds, and accelerated wear rates prior to age 20 years were not maintained in most areas of the dentition. A nonlinear progression with age was observed, thereby inhibiting prediction of subsequent attrition from prior levels. Attrition was concluded to have multifactorial etiology, with age and the geometry of canine guidance having a significant influence, in addition to commonly accepted parafunction.

Adult↗
PubMed1994

Histologic characteristics of the lateral pterygoid muscle insertion to the temporomandibular joint.

This study used low-power light microscopy to examine the histologic organization of the lateral pterygoid muscle interface with the temporomandibular joint. The sample included parasagittal sections of 20 intact temporomandibular joints from young adults (mean age 26.2 years) at autopsy. The lateral pterygoid muscle showed no consistent divisions into separate anatomic muscle heads at the insertion. The muscle fibers attached to the pterygoid fovea of the condyle immediately inferior to the articular surface in all cases. Some additional fibers inserted superiorly into the more anterior part of the articular disc in a minority of cases (31%). Fibers inserting into the disc represented only 2.4% to 6% of the total superior-inferior length of the muscle insertion. It is hypothesized that the muscular force exerted by these few fibers inserting into the disc would not be sufficient to displace the disc anteriorly to the condyle. There were two histologic types of insertion of the lateral pterygoid muscle to the condyle. The superior part of the insertion was characterized by an identifiable tendon inserting through fibrocartilage. In the inferior part of the insertion, the muscle attached to periosteum without an obvious tendon. The presence of this tendon must be recognized in interpretation of soft tissue temporomandibular joint imaging.

Adolescent↗
PubMed1993

Serial variation in histological character of articular soft tissue in young human adult temporomandibular joint condyles.

Histological variation was studied in serial sections, in contrast to previous studies which have generalized from representative sections. The sample consisted of consecutive serial sagittal sections from the central third of nine condyles, plus an accompanying stone cast showing the intact articular surface before sectioning. The thickness of the articular soft tissue and its fibrous connective tissue and cartilage components was measured, and the presence of undifferentiated mesenchymal (UM) cells was assessed by low-power light microscopy. Components of variance analysis showed that section-to-section variation in thickness was of the same order as differences between joints, each explaining approx. 50% of the variance in both connective tissue and cartilage thickness. The fibrous connective tissue contributed as much to the overall variation in soft tissue thickness as did the cartilage component (SD 0.0946 versus 0.0909 mm for the superior sector). Serial UM cell variability was common, and the UM cells were often distributed in islands rather than uniformly across the articular tissue. Condyles with the greatest surface irregularity were characterized by greater serial variability in fibrous connective tissue thickness, more frequent absence of cartilage, and more areas of UM cell depletion. These results suggest that serial variation in histological character may be more important than mean values in the description of surface contours and articular tissue relations in the temporomandibular joint. This should influence the design of future investigations.

Adult↗
PubMed1993

Contour mapping of the TMJ temporal component and the relationship to articular soft tissue thickness and disk displacement.

The osseous architecture of central sagittal histologic sections of the temporal component of 51 temporomandibular joints of young adults at autopsy was studied to determine if this predicted the thickness of the overlying articular soft tissue and disk displacement. Geometric groupings of fossa-eminence shapes were generated using a hierarchical cluster analysis of the osseous fossa-eminence sigmoid curve, size, and slope. Six cluster groups were evolved and tested for relationship to soft tissue thickness measured at the eminence crest, mid-point of the eminence slope, closed pack location of the condyle, the inflection point, and the depth of the fossa. Soft tissue thickness at the inflection point and depth of the fossa was remarkably constant between cluster groups. Increased soft tissue thickness at the eminence crest and lower part of the posterior slope was weakly correlated to a flatter eminence slope and curve, explaining 10% to 20% of the variance (r2). There were no relationships between the parameters studied to the fossa curvature. An ANOVA showed no statistical difference in the posterior slope angle between the categories of disk position (p = 0.715) or to the six cluster groupings. The results suggest that the osseous contours seen on radiographs may not accurately predict the actual articular surface of the temporal component.

Adolescent↗
PubMed1993

Relationship of articular soft tissue contour and shape to the underlying eminence and slope profile in young adult temporomandibular joints.

This study examined whether the overall shape of the articular soft tissue overlying the posterior slope and articular eminence of the temporal bone could be predicted by the underlying osseous contour in a histologic model of 51 central sagittal sections of young adult temporomandibular joints. Articular soft tissue and bone contours were traced, and osseous landmarks identified on the basis of joint geometry. Soft tissue thickness measurements were made under low power light microscopy. Seven categories of articular soft tissue pattern were identified. The soft tissue uniformly followed the osseous contour in only one (14%). A progressive increase in soft tissue thickness from the middle of the posterior slope to the articular crest was the most common pattern (35%) but did not describe most of the sample that was more asymmetric. Pattern was poorly predicted by the shape and slope of the temporal bone outline or by dental factors that describe anterior guidance and did not relate to disk displacement. The articular soft tissue compensated for flatter eminence slopes and osseous irregularities and maintained an intact surface. This study has clinical implications for radiographic interpretation of disk space, condyle translation pathways, and the integrity of the functional articular surface.

Adolescent↗
PubMed1993

A multiple logistic regression analysis of the risk and relative odds of temporomandibular disorders as a function of common occlusal features.

A multiple logistic regression analysis was used to compute the odds ratios for 11 common occlusal features for asymptomatic controls (n = 147) vs. five temporomandibular disorder groups: Disc Displacement with Reduction (n = 81), Disc Displacement without Reduction (n = 48), Osteoarthrosis with Disc Displacement History (n = 75), Primary Osteoarthrosis (n = 85), and Myalgia Only (n = 124). Features that did not contribute included: retruded contact position (RCP) to intercuspal position (ICP) occlusal slides < or = 2 mm, slide asymmetry, unilateral RCP contacts, deep overbite, minimal overjet, dental midline discrepancies, < or = 4 missing teeth, and maxillo-mandibular first molar relationship or cross-arch asymmetry. Groupings of a minimum of two to at most five occlusal variables contributed to the TMD patient groups. Significant increases in risk occurred selectively with anterior open bite (p < 0.01), unilateral maxillary lingual crossbite (p < 0.05 to p < 0.01), overjets > 6-7 mm (p < 0.05 to p < 0.01), > or > 5-6 missing posterior teeth (p < 0.05 to p < 0.01), and RCP-ICP slides > 2 mm (p < 0.05 to p < 0.01). While the contribution of occlusion to the disease groups was not zero, most of the variation in each disease population was not explained by occlusal parameters. Thus, occlusion cannot be considered the unique or dominant factor in defining TMD populations. Certain features such as anterior open bite in osteoarthrosis patients were considered to be a consequence of rather than etiological factors for the disorder.

Age Factors↗
PubMed1993

The degree to which attrition characterizes differentiated patient groups of temporomandibular disorders.

Dental attrition severity as the cumulative record of parafunctional and functional wear was graded from study cast analysis using established methodology. Attrition severity was compared in anterior, posterior mediotrusive, and posterior laterotrusive segments. Attrition scores in 48 female and 100 male totally asymptomatic controls were compared to 239 female and 31 male patients differentiated into five patient groups of temporomandibular disorders: (1) disc displacement with reduction, (2) disc displacement without reduction, (3) osteoarthrosis with a history of prior derangement, (4) osteoarthrosis without a history of prior derangement, and (5) myalgia only. All the male patients were in the myalgia-only group. Age was controlled in the analysis to control for functional wear. Comparisons between patients and controls were made according to 10-year age intervals. Analysis included ANCOVA confirmed by a Games-Howell post-hoc test, with P < .01 interpreted as a significant difference in the attrition score. Only 1 of 112 ANCOVAs showed a significant difference, with younger men from 20 to 29 years of age in the myalgia-only group having lower mediotrusive attrition than the male controls. It would therefore be difficult if not impossible to differentiate patients from nonpatients based on the severity of dental attrition. Consequently, a major peripheral occlusal etiologic role for attrition in TMD is questioned. Some clinical implications are elaborated.

Adult↗
PubMed1993

The articular-synovial lining tissue system in temporomandibular joints of young adults.

The histologic character of the articular surfaces and synovial tissues in the temporomandibular joints of 20 young adults was described. Each joint compartment had a continuous connective-tissue lining that was fibrous on the articular surfaces, went through a transition, and was continuous with the lining tissue in the recesses. Areolar synovial tissue was found only in the upper posterior recess of the temporomandibular joint, fibrous synovial tissue was predominantly found in the upper anterior and lower posterior recesses, and an intermediate type of synovial tissue was found in the lower anterior recess. There was no distinct boundary between articular and synovial tissue. The structure and continuity of these lining tissues suggest that they constitute a continuous tissue system, here termed the "articular-synovial lining tissue system," that has a histologic character which depends on location and functional demands. It is hypothesized that all of the lining tissues should be considered synovial, based on a functional definition of nonadherence.

Adolescent↗
PubMed1992

The relationship of undifferentiated mesenchymal cells to TMJ articular tissue thickness.

Undifferentiated mesenchymal (UM) cells, the progenitor cells of the cartilage layer, have been assigned a significant role in TMJ articular tissue maintenance. This was based on reports of UM cell reduction with increased soft-tissue thickness for the condyle and temporal component. However, the strength of this inverse relationship was not presented and remained unclear. The purpose of the present study was to assess the strength of the correlation between UM cell presence and soft-tissue thickness in young adult TMJs at autopsy. Sagittal histological sections from the central thirds of 50 joints were evaluated with respect to articular soft-tissue thickness, histological character, and UM cell presence in the condyle and temporal component. The superior sector of the condyle and the articular eminence showed the greatest variability in soft-tissue thickness and were the only areas to show localized UM cell absence. The eminence was the only location to show an inverse relationship between soft-tissue thickness and UM cell presence, and this was consistent in both an ANOVA (p = 0.0016) and a Spearman correlation analysis. However, the strength of this correlation was only moderate (rho = -0.52), and no such relationship was observed in any other location. This study suggests that the relationship between UM cell presence and soft-tissue thickness is more complex than previously hypothesized and that the contribution of UM cells to articular tissue maintenance has been overstated, while other biological processes were overlooked.

Adaptation, Physiological↗
PubMed1991

Trauma history in diagnostic groups of temporomandibular disorders.

Trauma history was studied for association with disease among six diagnostic subgroups of 230 patients with temporomandibular disorder (TMD) from a private practice setting with (1) disk displacement (DD) with reduction, (2) DD without reduction, (3) osteoarthrosis (OA) with prior derangement history, (4) primary OA, (5) myalgia only, and (6) subluxation only. Except for subluxation (29%), trauma history typified TMD patient groups 1 to 5 (63%, 79%, 44%, 53%, 54%) (p less than 0.001) compared with 13% and 18% of asymptomatic (n = 61) and symptomatic (n = 161) student control subjects, and 11% of general dental patients (n = 150). TMD groups 2 and 3 differed significantly (p less than 0.05). The high prevalence of trauma in the myalgia-only group complicates the concept of myofascial pain-dysfunction syndrome as solely a stress or centrally mediated disorder. DD without reduction (43%) and with reduction (38%) had the highest prevalences of motor vehicle accident trauma, myalgia and OA groups had less, and subluxation-only cases had none. On the other hand, patients with DD without reduction were also the only group to report multiple trauma (29%), suggesting that although specific traumatic events may seem to precipitate clinical symptoms, they may not always have initiated the problem. Trauma may be both an important cumulative and precipitating event in TMDs.

Accidents, Traffic↗
PubMed1991

Overbite and overjet characteristics of refined diagnostic groups of temporomandibular disorder patients.

Overbite and overjet were studied as continuous variables to examine for any relationship to diagnostic groups of temporomandibular disorders (TMD) compared with symptom-free controls. This avoided the bias of arbitrary definitions of normal and abnormal for these occlusal variables and also avoided the masking effect of studying symptoms rather than diagnostic entities. Incisal overbite in primary osteoarthrosis (OA) was shifted toward the minimal and open bite ranges as compared with the controls (p less than 0.02). Open bite occurred in only the two OA classes studied and in a few cases with myalgia only but was absent in the symptom-free controls. Overbite in myalgia was slightly skewed to the lower range. Deep bite was not more common in the myalgia, disk displacement (with or without reduction), or the OA groups. Increased overjet characterized OA groups, especially when there was a history of derangement (p less than 0.004), but did not characterize the other diagnostic groups. Except for open bite, overbite and overjet characteristics as isolated variables did not distinguish TMD patient groups. It is hypothesized that open bite in OA can be the result of joint changes rather than a predisposing occlusal cause.

Adult↗
PubMed1991

The role of intercuspal occlusal relationships in temporomandibular disorders: a review.

The purpose of this review is to highlight consensus in past research on the role of intercuspal occlusal factors in the pathophysiology of temporomandibular disorders. The occlusal intercuspal relationships considered are skeletal anterior open bite, overbite, overjet, symmetry of contacts in the retruded contact position (RCP), crossbite, and posterior occlusal support. Skeletal anterior open bite, reduced overbite, and increased overjet are associated with osteoarthritic TMJ patients, but lack specificity for defining patient populations per se. There is no evidence that overbite or overjet plays a role in the pathophysiology of nonarthritic disorders. A combination of unilateral RCP with an absence of a clinically apparent RCP-ICP (intercuspal position) slide may encourage TMJ disc displacement, but unilateral RCP per se was not associated with TMJ diagnoses. Crossbite does not seem to provoke TMJ symptoms or disease. Lost molar support may be associated with osteoarthrosis presence and severity, but studies have not yet been distinguished for age effects. Where appropriate, implications for clinical practice are drawn.

Humans↗
PubMed1991

The role of functional occlusal relationships in temporomandibular disorders: a review.

This review highlights the consensus existing in past research on the role of functional occlusal factors in the pathophysiology of temporomandibular disorders (TMD). The functional occlusal relationships considered are balancing and working occlusal contacts, length and symmetry of retruded contact position-intercuspal position (RCP-ICP) slides, occlusal guidance patterns, parafunction, and dental attrition. Controlled studies fail to demonstrate any association between occlusal interferences and TMD signs or symptoms. Temporomandibular joint condylar autorepositioning secondary to intracapsular arthrosis is associated with larger and asymmetric RCP-ICP slides. Other TMD conditions are not associated with any slide length or asymmetries. Occlusal guidance patterns are not associated with TMD symptom provocation or, conversely, health. Parafunction appears to be universal and is not associated with TMD development or symptomatology in healthy individuals. Furthermore, parafunction is not provoked by longstanding, naturally occurring occlusal variations. Dental attrition is not associated with TMD, and any observed increased attrition in osteoarthrosis patients is likely the result of age effects and occlusal alterations secondary to condylar positional changes.

Bruxism↗